COLLABORATORS - PROJECTS - MIRAGES
Funded Projects
HANSEN LAB
March 2014 - ongoing
Friend and mentor, Dr. Kirk C. Hansen is a world leading expert in the field of quantitative and extracellular matrix proteomics. Current projects with the Hansen Lab relate to systemic responses to trauma and hemorrhage, the intertwinement of tumor metabolism and microenvironment, Aging and Inflammation in Pulmonary Hypertension and Red Blood Cell biology. Kirk has been a great mentor and friend (Angelo has Post-doc'ed in Kikr's Lab). Dr. Hansen also Directs the Proteomics Core of the School of Medicine at the University of Colorado Denver.
XIA LAB
December 2014 - ongoing
The Xia Lab (University of Texas Houston - McGovern Medical School) is a world leading group in the field of red blood cell biology and systemic responses to hypoxia. Current collaborative projects with the D'Alessandro Lab also relate to stress erythropoiesis, acute kidney ischemia, pre-eclampsia and - in general - the role of the adenosine/sphingosine 1-phosphate axis in red blood cell biology and sickle cell disease. Yang is a passionate and friendly collaborative investigator who transmits her energy to the whole team. We share an unconditional love for red blood cells and hope to keep collaborating for several years to come!
STENMARK LAB
September 2015 - ongoing
At the forefront of research on cardiovascular diseases and pulmonary hypertension, the Stenmark lab (University of Colorado Denver) combines unique animal models (neonatal calf hypoxia), genetic tools and primary clinical samples to explore the next generation therapies.
ZIMRING LAB
September 2016 - ongoing
James C. Zimring (Chief Scientific Officer of BloodWorks Northwest - University of Washington - Seattle) is a genius immunologist with a soft spot for red blood cell biology. Combining elegant animal models and state of the art genetic tools the Zimring lab explores the impact of donor and recipient biology on erythrocyte and platelet storability and transfusion outcomes.
SPITALNIK LAB
September 204 - ongoing
Steve Spitalnik (Columbia University - New York) is a world leading expert in the field of red blood cell storage. In collaboration with Drs. Hod and Francis, Dr. Spitalnik focuses on the role of donor diet, iron and oxidative stress status in influencing red blood cell storability, transfusion outcomes and complications.
HOD LAB
February 2015 - ongoing
Eldad Hod (Columbia University - New York) investigates the role of the storage lesion and iron metabolism on the transfusion donor and recipient biology. Collaborative work has provided clues on the role of the metabolic storage lesion as a predictor of transfusion outcomes, as measured by 24h Post-Transfusion Recoveries.
FRANCIS LAB
September 2016 - ongoing
The Francis Lab (Columbia University - New York) explores the role of glucose 6-phosphate dehydrogenase deficiency on red blood cell biology and storability.
JORDAN LAB
2015 - ongoing
Craig Jordan (University of Colorado Denver) and his team are world leading experts and pioneers in the field of cancer stem cell biology. Current projects relate to the metabolic dependencies of patient-derived acute myeloid leukemia cells with the goal to tailor patient-specific and potentially universally-translatable therapies.
DEGREGORI LAB
May 2014 - ongoing
The DeGregori Lab (University of Colorado Denver) approaches cancer, aging and inflammation research from a unique evolutionary standpoint. Collaborations with the D'Alessandro Lab provide metabolic data to complement and expand upon Jame's group revolutionary perspective on these key biomedical challenges.
TRAUMA GROUP
March 2014 - ongoing
Trauma is the leading cause of mortality under the age of 44. The group lead by Dr. Anirban Banerjee gathered a group of expert PIs, including Drs. Ernest "Gene" Moore, Christopher C. Silliman, Angela Sauaia, Kirk Hansen and Angelo D'Alessandro to tackle the molecular issues underlying the etiology of multiple organ failure, acute lung injury and coagulopathy - preventable causes of death in the critically ill population.
OLD LAB
March 2017 - ongoing
The Old Lab (University of Colorado Boulder) combines state of the art phosphoproteomics technologies and biosensor-based measurements to provide a rapid and high-throughput overview of the mechanisms of action of known and unknown chemical and biological agents.
DOCTOR LAB
September 2016 - ongoing
Allan Doctor (University of Washington - St Louis) and his team are world leading experts in the field of red blood cell biology, oxygen transport and delivery. A collaborative project with the D'Alessandro Lab will try to understand the physiological and metabolic underpinnings of dysregulated red blood cell biology in sepsis.
MONTE LAB
October 2017 - ongoing
Clinical metabolomics is the next stage of clinical biochemistry. By leveraging a clinical genomics and metabolomics approach, the Monte (University of Colorado Denver) and D'Alessandro Labs will pave the way for the implementation of precision medicine programs in acute care settings.
HUMAN TRISOME PROJECT
April 2016 - ongoing
The Human Trisome Project - lead by Dr. Joaquin Espinosa (Linda Crnic Institute for Down Syndrome Research) combines integrated Omics, elegant animal models and clinical samples to investigate the etiological contributors to common comorbidities observed in individual with Trisomy 21, as well as genetic determinants that protect this population from developing solid tumors.
DINARELLO LAB
September 2015 - ongoing
Dr. Charles Dinarello (University of Colorado Denver) discovered interleukin 1. For most living mortals, that should be enough. However, Dr. Dinarello's research has spearheaded advancements in our understanding of processes related to inflammation and aging, and ways to counteract them.
KEDL LAB
October 2017 - ongoing
The Kedl Lab (University of Colorado Denver) explores the boundary between the innate and adaptive immune systems and seeks to elucidate signals and pathways emanating from the various families of innate receptors most efficiently mediate the transition to the adaptive cellular immune response and how this research can be translated to improve adjuvant-based vaccination treatments.
RINCON LAB
October 2015 - ongoing
If twenty years from now we will be treating aging and inflammation, boosting athletic performance and successfully treating chemoresistant cancers, at least part of it will be due to the brilliant research carried out by Mercedes Rincon (University of Vermont) and her team. By focusing on MCJ and mitochondrial metabolism, Rincon's group proposed some revolutionary ideas relevant to many research endeavors.
ROACH LAB
June 2014 - ongoing
Rob Roach is the head of the Altitude Research Center at the University of Colorado Denver School of Medicine and head of the AltitudeOmics project. His group has pioneered for decades the understanding at the physiological (and now multi-omics) level of human responses to high altitude hypoxia.