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COLLABORATORS - PROJECTS - MIRAGES

Funded Projects

HANSEN LAB

March 2014 - ongoing

Friend and mentor, Dr. Kirk C. Hansen is a world leading expert in the field of quantitative and extracellular matrix proteomics. Current projects with the Hansen Lab relate to systemic responses to trauma and hemorrhage, the intertwinement of tumor metabolism and microenvironment, Aging and Inflammation in Pulmonary Hypertension and Red Blood Cell biology. Kirk has been a great mentor and friend (Angelo has Post-doc'ed in Kikr's Lab). Dr. Hansen also Directs the Proteomics Core of the School of Medicine at the University of Colorado Denver.

XIA LAB

December 2014 - ongoing

The Xia Lab (University of Texas Houston - McGovern Medical School) is a world leading group in the field of red blood cell biology and systemic responses to hypoxia. Current collaborative projects with the D'Alessandro Lab also relate to stress erythropoiesis, acute kidney ischemia, pre-eclampsia and - in general - the role of the adenosine/sphingosine 1-phosphate axis in red blood cell biology and sickle cell disease. Yang is a passionate and friendly collaborative investigator who transmits her energy to the whole team. We share an unconditional love for red blood cells and hope to keep collaborating for several years to come!

ZIMRING LAB

September 2016 - ongoing

James C. Zimring (Chief Scientific Officer of BloodWorks Northwest - University of Washington - Seattle) is a genius immunologist with a soft spot for red blood cell biology. Combining elegant animal models and state of the art genetic tools the Zimring lab explores the impact of donor and recipient biology on erythrocyte and platelet storability and transfusion outcomes.

STENMARK LAB

September 2015 - ongoing

At the forefront of research on cardiovascular diseases and pulmonary hypertension, the Stenmark lab (University of Colorado Denver) combines unique animal models (neonatal calf hypoxia), genetic tools and primary clinical samples to explore the next generation therapies.

SPITALNIK LAB

September 204 - ongoing

Steve Spitalnik (Columbia University - New York) is a world leading expert in the field of red blood cell storage. In collaboration with Drs. Hod and Francis, Dr. Spitalnik focuses on the role of donor diet, iron and oxidative stress status in influencing red blood cell storability, transfusion outcomes and complications.

HOD LAB

February 2015 - ongoing

Eldad Hod (Columbia University - New York) investigates the role of the storage lesion and iron metabolism on the transfusion donor and recipient biology. Collaborative work has provided clues on the role of the metabolic storage lesion as a predictor of transfusion outcomes, as measured by 24h Post-Transfusion Recoveries.

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CONNES LAB

The Connes Lab specializes on RBC deformability and sports physiology. Current projects relate to RBC responses in athletes (including cycling, marathon and ultra-marathon athelete), diabetes and sickle cell disease.

2019-ongoing

JORDAN LAB

2015 - ongoing

Craig Jordan (University of Colorado Denver) and his team are world leading experts and pioneers in the field of cancer stem cell biology. Current projects relate to the metabolic dependencies of patient-derived acute myeloid leukemia cells with the goal to tailor patient-specific and potentially universally-translatable therapies.

BUEHLER LAB

The Buehler Lab at the University of Maryland holds a solid expertise in tissue oxygenation measurements, EPR and other biophysical measurements. Collaborations relate to studies of Sickle Cell Disease and COVID-19. 

2019-ongoing

DEGREGORI LAB

May 2014 - ongoing

The DeGregori Lab (University of Colorado Denver) approaches cancer, aging and inflammation research from a unique evolutionary standpoint. Collaborations with the D'Alessandro Lab provide metabolic data to complement and expand upon Jame's group revolutionary perspective on these key biomedical challenges.

TRAUMA GROUP

March 2014 - ongoing

Trauma is the leading cause of mortality under the age of 44. The group lead by Dr. Anirban Banerjee gathered a group of expert PIs, including Drs. Ernest "Gene" Moore, Christopher C. Silliman, Angela Sauaia, Kirk Hansen and Angelo D'Alessandro to tackle the molecular issues underlying the etiology of multiple organ failure, acute lung injury and coagulopathy - preventable causes of death in the critically ill population.

PLUCHINO LAB

The Pluchino lab (Cambridge, UK) focuses on neurodegenerative diseases and the role of metabolic reprogramming (especially mitochondrial dysfunction) in the etiology of these diseases

March 2019 - ongoing

DOCTOR LAB

September 2016 - ongoing

Allan Doctor (University of Maryland) and his team are world leading experts in the field of red blood cell biology, oxygen transport and delivery. A collaborative project with the D'Alessandro Lab will try to understand the physiological and metabolic underpinnings of dysregulated red blood cell biology in sepsis.

MONTE LAB

October 2017 - ongoing

Clinical metabolomics is the next stage of clinical biochemistry. By leveraging a clinical genomics and metabolomics approach, the Monte (University of Colorado Denver) and D'Alessandro Labs will pave the way for the implementation of precision medicine programs in acute care settings.

HUMAN TRISOME PROJECT

April 2016 - ongoing

The Human Trisome Project - lead by Dr. Joaquin Espinosa (Linda Crnic Institute for Down Syndrome Research) combines integrated Omics, elegant animal models and clinical samples to investigate the etiological contributors to common comorbidities observed in individual with Trisomy 21, as well as genetic determinants that protect this population from developing solid tumors.

DINARELLO LAB

September 2015 - ongoing

Dr. Charles Dinarello (University of Colorado Denver) discovered interleukin 1. For most living mortals, that should be enough. However, Dr. Dinarello's research has spearheaded advancements in our understanding of processes related to inflammation and aging, and ways to counteract them.

KEDL LAB

October 2017 - ongoing

The Kedl Lab (University of Colorado Denver) explores the boundary between the innate and adaptive immune systems and seeks to elucidate signals and pathways emanating from the various families of innate receptors most efficiently mediate the transition to the adaptive cellular immune response and how this research can be translated to improve adjuvant-based vaccination treatments.

RINCON LAB

October 2015 - ongoing

If twenty years from now we will be treating aging and inflammation, boosting athletic performance and successfully treating chemoresistant cancers, at least part of it will be due to the brilliant research carried out by Mercedes Rincon (CU Anschutz ) and her team. By focusing on MCJ and mitochondrial metabolism, Rincon's group proposed some revolutionary ideas relevant to many research endeavors.

ROACH LAB

June 2014 - ongoing

Rob Roach is the head of the Altitude Research Center at the University of Colorado Denver School of Medicine and head of the AltitudeOmics project. His group has pioneered for decades the understanding at the physiological (and now multi-omics) level of human responses to high altitude hypoxia.

Collaborators and partners in (hopefully soon-to-be-funded!) projects

BLOOD STORAGE

  • Allan Doctor (University of Maryland)

  • Anastasios Kriebardis (University of Athens, Greece)

  • Andrew Dunham (New Health Sciences inc, USA)

  • Bernhard Palsson (University of California San Diego, USA)

  • Christopher Silliman (Bonfils Blood Center, USA)

  • Dirk de Korte (Sanquin Blood Center, The Netherlands)

  • Giancarlo Liumbruno (Italian National Blood Centre)

  • Issidora Papassideri (University of Athens, Greece)

  • James C Zimring (University of Virginia)

  • Larry Dumont (Blood Systems Research Institute – Denver, USA)

  • Lello Zolla (Tuscia University, Italy)

  • Marianna Antonelou (University of Athens, Greece)

  • Matthew Karafin (Blood Center of Wisconsin, USA)

  • Matthew Landrigan (Zimmer Biomet, USA)

  • Matthew Stotts (University of Virginia)

  • Mike Busch (Blood Systems Research Institute - San Francisco, USA)

  • Pavel Swietach (University of Oxford, UK)

  • Pedro Cabrales (University of California San Diego, USA)

  • Robin van Bruggen (Sanquin Blood Center, The Netherlands)

  • Steven Spitalnik (Columbia University, NY)

  • Tatsuro Yoshida (New Health Sciences inc, USA)

  • Thom Raife (University of Wisconsin, USA)

  • Tiffany Thomas (Columbia University, USA)

  • Xiaoyun Fu (BloodWorks Northwest, USA)

  • Zigbignew Szczepiorkowski (Darthmouth, USA)

AGING, HYPOXIA AND INFLAMMATION

  • Ana Maria Cuervo (Einstein University, USA)

  • Brent Stockwell (Columbia University, USA)

  • Brian Graham (University of Colorado Denver, USA)

  • Britta Will (Einstein University, USA)

  • Charles Dinarello (University of Colorado Denver, USA)

  • Chris Phiel (University of Colorado Denver, USA)

  • Dan Ambruso (University of Colorado Denver, USA)

  • Doug Seals (University of Colorado Boulder, USA)

  • Elan Eisenmesser (University of Colorado Denver, USA)

  • Eyal Amiel (University of Vermont, USA)

  • James Costello (University of Colorado Denver, USA)

  • Jed Friedman (University of Colorado Denver, USA)

  • Joe Hurt (University of Colorado Denver, USA)

  • Jorge Di Paola (University of Colorado Denver, USA)

  • Karim El Kasmi (University of Colorado Denver, USA)

  • Kelly Drew (University of Alaska Fairbanks, USA)

  • Kenneth MacLean  (University of Colorado Denver, USA)

  • Laura Santambrogio (Einstein University, USA)

  • Moshe Levi (University of Colorado Denver, USA)

  • Paola Caruso (Cambridge, UK)

  • Ralph Budd (University of Vermont, USA)

  • Ron Sokol (University of Colorado Denver, USA)

  • Sachin Gupte (New York Medical College, USA)

  • Sarah Faubel (University of Colorado Denver, USA)

  • Tobias Eckle (University of Colorado Denver, USA)

  • William Janssen (National Jewish Health, USA)

  • Yvonne Janssen-Heiniringer (University of Vermont, USA)

TRAUMA & HEMORRHAGIC SHOCK

  • Forest Shepard (US Navy San Antonio, USA)

  • Hunter Moore (University of Colorado Denver, USA)

  • Kalev Freeman (University of Vermont)

  • Nate Weitzel (University of Colorado Denver, USA)

  • Nathan Clendenen (University of Colorado Denver, USA)

  • Per Johansson (University of Copenhage, Denmark)

CANCER METABOLISM

  • Carlos Catalano (University of Colorado Denver, USA)

  • Dan Theodorescu (University of Colorado Denver, USA)

  • David Jones (University of Colorado Denver, USA)

  • Heide Ford (University of Colorado Denver, USA)

  • Isabel Schlaepfer (University of Colorado Denver, USA)

  • Jennifer Richer (University of Colorado Denver, USA)

  • Jose Cancelas (University of Cincinnati, USA)

  • Mark Gregory (University of Colorado Denver, USA)

  • Matthew Gailbraith (University of Colorado Denver, USA)

  • Pepper Schedin (University of Colorado Denver, USA)

  • Steve Anderson (University of Colorado Denver, USA)

  • Todd Pitts (University of Colorado Denver, USA)

DIET, OBESITY, CIRCADIAN RHYTHM & SPORT

  • Bryan Bergman (University of Colorado Denver, USA)

  • Chen Zheng (University of Texas Houston, USA)

  • Inigo San Millan (University of Colorado Boulder, USA)

  • Karen Jonscher (University of Colorado Denver, USA)

  • Laura Brown (University of Colorado Denver, USA)

  • Nohara Kazunari (University of Texas Houston, USA)

  • Paul MacLean (University of Colorado Denver, USA)

  • Robert Freedman (University of Colorado Denver, USA)

  • Stephanie Wesolowski (University of Colorado Denver, USA)

  • Tania Reis (University of Colorado Denver, USA)

  • David Irwin (University of Colorado Denver, USA)

STRESS ERYTHROPOIESIS

  • Britta Will (Einstein University, USA)

  • Dani Luca (University of Cincinnati)

  • Eric Pietras (University of Colorado Denver, USA)

  • Hartmut Geiger (Unviersity of Cincinnati)

  • Jim Palis (University of Rochester Medical Center)

  • Jose Cancelas (University of Cincinnati)

  • Marie Dominique Filippi (University of Cincinnati)

©2018 by D'Alessandro Lab

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