Our lives are not our own. We are bound to others, past and present, and by each crime and every kindness, we birth our future. David Mitchell
Angelo D'Alessandro, PhD
Angelo D’Alessandro is a tenured Full Professor in the Department of Biochemistry and Molecular Genetics. He is the founder and Director of the Metabolomics Core of CU Anschutz School of Medicine and the director of the Mass Spectrometry Shared Resource for the University of Colorado Cancer Center. Age 39, he has published over 500 papers, research sponsored by NHLBI, NIDDK and NIGMS. He is the founder and CSO of Omix Technologies Inc, Altis Biosciences, and serves as an advisory board member for Hemanext Inc, and Macopharma. He is a Boettcher Investigator, AABB Hall of Fame, Jean Julliard (ISBT) and RISE (AABB) awardee. He is also an affiliate investigator to the Vitalant Research Institute, the Linda Crnic Institute for Down syndrome, the Gates Grubstake Center for Regenerative Medicine.
Julie A. Reisz Haines, PhD
Research Assistant Professor
Julie is a native of Pittsburgh and has a B.S. in Chemistry from Allegheny College and Ph.D. in Chemistry from Wake Forest University. Her Ph.D. work focused on the reactivity of nitrogen oxides with synthetic organophosphines and thiol- and heme-containing enzymes. Her postdoctoral projects at Wake Forest School of Medicine (Section on Molecular Medicine) studied redox modifications of protein cysteines, particularly in the peroxiredoxin family, using MS-based proteomics. After a short stint teaching undergraduate organic chemistry, she joined the D’Alessandro lab in 2015 where she contributes to RBC metabolism projects and manages the CU SOM Metabolomics Core. Her specific research interests include metabolic responses along the spectrum from hypoxia to oxidative stress and in particular, RBC protein oxidation. Outside of science, Julie is a parent of 3 young kiddos and an avid runner.
Travis Nemkov, PhD
Research Assistant Professor
Travis specializes in studying blood's pivotal role in maintaining the body's balance and its transportation functions for nutrients, waste, cells, and signaling molecules. Using cutting-edge mass spectrometry-based methods, we explore diverse blood samples to identify unique signatures distinguishing healthy and diseased states. These findings play a critical role in refining blood transfusion treatments, supporting cancer patients experiencing anemia, fatigue, or cachexia, and optimizing endurance training. Alongside this, Travis is developing a high-throughput screening platform that has already examined over 20,000 compound-cell line interactions, shedding light on their metabolic impacts. These integrated platforms enable us to study large human cohorts, deciphering biological phenomena and linking signatures to drug-metabolome interactions. Over the last decade, they've driven numerous publications and patents, fueling our excitement for future breakthroughs.
Monika Dzieciatkowska, PhD
Director of Mass Spectrometry operations
Monika is our local mass spec expert, in that she can disassemble and reassemble any of our "toys" in the lab. Her expertise and analytical skills are essential to the routine operations of the Hansen and D'Alessandro Labs, as well as of the Cores they direct.
Aaron Issaian, PhD
Aaron graduated in Structural Biology and Biochemistry in the Hansen Lab. During his PhD he developed techniques to perform protein-protein interaction studies through chemical cross-linkers in multiple samples through TMT approaches. He also developed thermal proteome profiling and PISA assays to probe protein-protein or metabolite-protein interactions. His main current project is on the role of band 3 in RBC biology.
Shaun Bever is an honest-goodness Colorado Native who grew up in the Denver Metro area and received his B.S. in Chemistry from Colorado School of Mines. After a successful stint as the Facility Manager of the Biophysics Core at the University of Colorado Anschutz, Shaun returned to Colorado School of Mines to earn a Ph.D. in Geochemisty. His graduate work focused on the application of Atomic Mass Spectrometry to study the degradation of anthropogenic nanomaterials in the environment. After graduate school, Shaun returned to the University of Colorado Anshutz Medical Campus where he joined the D’Alessandro lab where he applies his broad knowledge base in analytical chemistry, biomolecular structure and mass spectrometry to core and research projects.
Daniel Stephenson, PhD
Daniel recently joined the lab as a senior staff member in the metabolomics core. As part of his PhD work and training he specialized on lipidomics analyses via mass spectrometry, though his solid analytical chemistry skills were readily transferable to metabolomics and ICP-MS applications.
Colin Anderson, PhD, MSFS
Colin grew up in Dallas, TX (Go Cowboys) and received his B.S. in biology from Southwestern University near Austin, TX. He then went on to pursue a career in forensics, earning his master's in forensic science from Sam Houston State University near Houston, TX and working over four years as a forensic chemist at the Maricopa County (Phoenix, AZ) Office of the Medical Examiner. He then migrated to Denver to earn his Ph.D. in toxicology at the School of Pharmacy under Dr. James Roede, his thesis project involving molecular mechanisms of toxicity of the pesticide maneb in neuronal cell culture as a toxicant model of Parkinson's disease. Of note, Colin collaborated with core lab during his thesis, publishing several papers on nutrient flux metabolomics with the group. After graduating, Colin travelled out west for a short post-doc at the Buck Institute for Aging under Dr. Martin Brand, followed by a short industry post at BioMarin Pharmaceuticals. Colin and his family are excited to be back in Colorado and encourage you to come out and see his band (Uncle Beef's Band) of fellow scientists around town!
Francesca, a Colorado native, specializes in using advanced MS-based methods to investigate how exercise affects proteomic and metabolomic profiles in humans and mice. Her research spans intriguing areas, exploring Critical Speed's impact on metabolic pathways and uncovering the intricate relationship between exercise and cardiovascular health through hemodynamics studies. Additionally, Francesca employs electron microscopy to delve into detailed insights on physiological processes such as red blood cell and heart morphologies. Her dedication lies in revealing the connections between exercise and metabolic pathways associated with conditions like cardiovascular diseases, hemolytic disorders, and cancer. Through precise mass spectrometry analysis, Francesca aims to shed light on the profound impact of exercise on various physiological systems.
Ian's research delves into the molecular signatures embedded within plasma collected from severely injured trauma patients. Utilizing advanced mass spectrometry techniques has unveiled intricate patterns that signify profound systemic alterations in response to trauma. By scrutinizing these molecular footprints, one of my aims is to enhance diagnostic precision and pave the way for targeted therapeutic interventions. His investigations extend beyond clinical observations, employing rigorous testing of specific mechanisms in animal models to further elucidate the complexities of severe traumatic injury.
Alicia Key, MS
Alicia's research interests revolve around red blood cells, focusing on the integration of metabolomics and systems biology. She seeks to explore the metabolic pathways within red blood cells to better understand their functionality and potential applications in health and disease. Alicia's work aims to bridge the gap between molecular-level data and system-level behavior, offering insights into the dynamic interactions governing red blood cell biology.
Professional Research Assistant
Amy graduated from Metropolitan State University of Denver with a BSc in biochemistry where she worked in an undergraduate research lab focused on the spatiotemporal neuronal translation regulation by the inherently disordered DCC receptor. After a summer internship at CU Anschutz through the RNA biosciences initiative studying nonsense-mediated decay of RNA, she decided to come back to Anschutz after graduation to work as a PRA for the metabolomics core performing UHPLC-MS analyses for many different collaborators. She is in the process of admission interviews for the Structural Biology, Biochemistry and Biophysics program. When not in the lab, she likes to see live music, paint, and hang out with her two cats.