Our lives are not our own. We are bound to others, past and present, and by each crime and every kindness, we birth our future. David Mitchell
Angelo D'Alessandro, PhD
Angelo D’Alessandro, PhD is a tenured Associate Professor in the Department of Biochemistry and Molecular Genetics at the University of Colorado Denver – Anschutz Medical Campus. He is also founder and director of the Metabolomics Core of the School of Medicine and Colorado Cancer Center. He received his PhD at the Tuscia University (Italy) under the aegis of the Italian National Blood Center. His postdoctoral career focused on Mass Spectrometry-based Omics technologies at Bruker Daltonics (Bremen, Germany), the Beatson Institute for Cancer Center (Glasgow, Scotland) and the University of Colorado Denver (Aurora, USA). He also serves as Linda Crnic Investigator for the Linda Crnic Institute of Down Syndrome. He is a founder and CSO of Omix Technologies Inc. and Altis Biosciences LLC. He serves as Associate Editor for the journal Blood Transfusion. He has been awarded the 2015 Scott Murphy lectureship by the Biomedical Excellence for Safer Transfusion (BEST) group, the Early Career grant by the National Blood Foundation (2016), the 2017 Webb-Waring Early Career grant by the Boettcher Foundation, NBF Scholar (2018), Jean Julliard Award by ISBT (2020) and NBF Innovation Award (2020). Age 37, he has published over 350 papers in peer-reviewed scientific journals and two books.
Julie A. Reisz Haines, PhD
Research Assistant Professor
Julie is originally from Pittsburgh, PA and received her PhD in Chemistry from Wake Forest University where she used NMR and MS to investigate the reactivity of nitrogen oxides with organophosphines and thiol- and heme-containing enzymes. Her postdoctoral work at Wake Forest School of Medicine (Section on Molecular Medicine) focused on redox modifications of protein cysteines, particularly in the peroxiredoxin family, using MS-based proteomics approaches. She next taught undergraduate level chemistry and managed the MS facility at Wake Forest, then joined the University of Colorado in 2015 where she utilizes high throughput metabolomics to profile metabolic responses occurring in numerous diseases and physiological perturbations. Her specific research interests include metabolic responses along the spectrum from hypoxia to oxidative stress and investigating RBC protein oxidation during storage. Outside of science, Julie enjoys hiking with her family and running half marathons.
Travis Nemkov, PhD
Research Assistant Professor
After completing his BA at the University of Colorado, Travis helped to jump start operations as the first employee at a new start-up company, AmideBio, where he developed methods to produce notoriously difficult peptides with high purity and efficiency. Four years later, he left to pursue a PhD in Dr. Kirk Hansen’s lab at the University of Colorado Denver where he developed high-throughput methods for metabolomics to study RBC responses to hypoxia and storage and published more than 40 papers in the process. Having already worked closely with Angelo on these projects, Travis decided to stick around as his first post-doctoral fellow where he has been focused now on high-throughput proteomics. In addition, he is interested in understanding the role of metabolism in blood cell development throughout the arc of life, from primitive embryonic erythropoiesis to chronic anemia of inflammation seen later in life. Born and raised in Colorado, Travis refuses to leave if he doesn’t have to, and just prefers to travel the world instead.
Monika Dzieciatkwowska, PhD
Proteomics Core Manager
Monika is our local mass spec expert, in that she can disassemble and reassemble any of our "toys" in the lab. Her expertise and analytical skills are essential to the routine operations of the Hansen and D'Alessandro Labs, as well as of the Cores they direct.
Aaron Issaian, PhD
Aaron graduated in Structural Biology and Biochemistry in the Hansen Lab. During his PhD he developed techniques to perform protein-protein interaction studies through chemical cross-linkers in multiple samples through TMT approaches. He also developed thermal proteome profiling and PISA assays to probe protein-protein or metabolite-protein interactions. His main current project is on the role of band 3 in RBC biology.
Fabia Gamboni, PhD
Fabia Gamboni has joined the lab in 2019, after over 25 years of work in the Trauma group in the CU Anschutz Trauma Research Center. Though her main expertise is in fluorescent and confocal microscopy, she has recently approached mass spectrometry-based metabolomics and will carry out metabolomics measurements within the framework of the RM1 project on Trauma-induced coagulopathic and inflammtory complications. Owing to her expertise and protective personality, she has accepted her unofficial position as the Lab's mom!
Daniel Stephenson, PhD
Daniel recently joined the lab as a senior staff member in the metabolomics core. As part of his PhD work and training he specialized on lipidomics analyses via mass spectrometry, though his solid analytical chemistry skills were readily transferable to metabolomics and ICP-MS applications.
Rachel Culp-Hill, M.Sc.
Rachel Culp-Hill is a PhD student in the Structural Biology and Biochemistry program, where she uses mass spectrometry to study the unique metabolome of leukemic stem cells in acute myeloid leukemia. Her previous training applied metabolomics to numerous projects including metabolic alterations in Down Syndrome, sickle cell disease, breast cancer, hemorrhagic shock, red blood cell storage and transfusion medicine. In addition to earning a M.S. in Microbiology from the University of Florida, her undergraduate training included majoring in Biochemistry and Molecular Biology at Michigan State University while using mass spectrometry to develop a method for the detection of pyrethroid pesticides at the MSU Veterinary Diagnostic Laboratory. When she’s not in the lab, Rachel enjoys hiking, embroidering, and spending time with her dog Kelby.
Francesca Cendali, MSc
Francesca graduated from Colorado College with a BSc in Molecular Biology and Biochemistry where she focused on effects of RNA binding and cancer research on Jurkat Cells. She spent a year and a half after college working with antiviral drug adherence at CU School of Pharmacy. She is new to the metabolomics lab and am excited to start working on projects. Outside of the lab she enjoys playing basketball, traveling and spending time with family.
Ian Lacroix, M.Sc.
Ian recently joined the lab as a graduate student. His goal is to develop and grow a thesis project focused on Trauma research using a multi-omics approach. Improve my mass spectrometer maintenance and troubleshooting skills. Take programming courses that will prepare me to leverage data visualization and machine learning to mine metabolites, proteins of interest. Establish inter-disciplinary collaborations, centralized around the use of mass spectrometry. For instance, I’m interested in learning more about immunology, sports performance, high altitude hypoxia. Hoping to jump on a project involving some of the listed areas. Additionally, I plan to participate in outreach, particularly in underserved communities surrounding the Anschutz Medical Campus. Present a poster or talk at a conference, for example ASMS. Intern with a private company or travel to a collaborator’s lab, for ~3months. At the end of 5 years, my goal is to Post Doc (industrial or university) or go straight into industry somewhere in Europe.
Keisha Alexander, MSc
Keisha is a graduate student in the Pharmaceutical Sciences program at the CU Anschutz School of Pharmacy. After an experience in the industry, Keisha decided to further her training in mass spectrometry-based analyses of small molecules. As part of her project in the D'Alessandro Lab, she is investigating the impact of sex and gender-defining hormones on systems metabolism, with a special focus on red blood cell biology and storability.
Rebecca Wilkerson (maiden Burgoyne), MSc
Professional Research Assistant
In five years from now, I see myself continuing to research and study in metabolomics and biochemistry. I hope to be working for this lab under the direction of Dr. Angelo D’Alessandro and to be able to participate in the new discoveries that are benefitting our understanding of health. It is my hope to be a part of discovering the biological imprints that abnormalities in the body leave on red blood cells. There is much to learn and do and I plan to return to school for my Ph.D. in biochemistry to continue my education so that I may be more helpful in this field of research. I find exercising my mind to be extremely important as I seek to raise a new family simultaneously.
Davide Stefanoni, MSc
Davide trained as a Professional Resaerch Assistant in the lab, while currently he is focusing on finalizing his PhD work at the Istituto San Raffaele di Milano. His current main project is on the role of BRAF V600E mutation on cell metabolism and disease.