ISSUES EDITED

Special Issue

Blood Transfusion

Red Blood Cell storage and clinical outcomes

Special Issue

Journal of Proteomics

December 2012

Methods in

Molecular Biology

2019

COVERS

Transfusion - Cover

June 2016

Transfusion - Cover

February 2016

Blood Transfusion - Cover

January 2016

2019

216. D’Alessandro A, Liumbruno GM. Personalized Transfusion Medicine. Blood Transfusion 2019; Accepted – waiting for doi
215.Hoffman CM, Hunter S, D’Alessandro A, Noonan K, Freedman R. Choline Mitigation of Marijuana’s Effects on the Fetal Brain and Child Behavior. Psychological Medicine 2019; Accepted – waiting for doi
•   214. Williams AT, Jani V, Nemkov T, Lucas A, Yoshida T, Dunham A, D’Alessandro A, Cabrales P. Anaerobically versus conventionally stored blood transfusion after trauma. Shock 2019; Accepted – waiting for doi
•   213. Howie HL, Hay A, de Wolski K, Waterman H, Fu X, Culp-Hill R, D’Alessandro A, Thomson P, Zimring JC. Genetic Variation of Steap3 Expression is Responsible for Altered Oxidative Damage and Post-Storage RBC Transfusion Biology in a Murine Model. Blood Advances 2019; Accepted – waiting for doi
•   212. Jones CL, Stevens BM, D’Alessandro A, Culp-Hill R, Reisz JA, Khan N, Agnello G, Rowlinson S, DeGregori J, Pollyea DA, Jordan CT. Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. Blood 2019; doi: 10.1182/blood.2019898114.
•   211. Gaikwad H, Wang G, Smith WJ, Alexander KL, D’Alessandro A, Zhang W, Purev E, Simberg D. Clickable Methyltetrazine-Indocarbocyanine Lipids: A Multicolor Tool Kit for Efficient Modifications of Cell Membranes. Bioconjug Chem. 2019; doi: 10.1021/acs.bioconjchem.9b00202.
•   210. Nechiporuk T, Kurtz SE, Nikolova O, Liu T, Jones CL, D’Alessandro A, Culp-Hill R, d’Alemeida A, Rosenberg M, Tognon C, Danilov AV, Druker BJ, McWeeney SK, Tyner JW. A genome-wide CRISPR screen on AML cells reveals TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition. Cancer Discovery 2019; doi: 10.1158/2159-8290.CD-19-0125.
•   209. Schmitt L, Henderson R, Barrett A, Darula Z, Issaian A, D’Alessandro A, Chalkley R, Clendenen N, Hansen KC. Molecular Mapping of FXIIIa Cross-links in fibrin clots using cross-linking-Mass Spectrometry. JBC 2019; doi: 10.1074/jbc.AC119.007981.
•   208.Adane B, Ye H, Khan N, Pei S, Minhajuddin M, Stevens BM, Jones CL, D’Alessandro A, Reisz JA, Zaberezhnyy V, Gasparetto M, Ho TC, Kelly KK, Myers JR, Ashton JM, Siegenthaler J, Kume T, Campbell EL, Pollyea DA, Becker MW, Jordan CT. The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells. Cell Rep. 2019 Apr 2;27(1):238-254.e6.
•   207. Francis RO, Mahajan S, Rapido F, La Carpia F, Soffing M, Divgi C, Yeh R, Mintz A, Leslie L, Agrest I, Karafin M, Ginzburg Y, Kessler D, Shaz BH, Spitalnik SL, Schwartz J, Fu X, Amireault P, Buffet P, Zimring JC, D’Alessandro A, Hod EA. Re-examination of the chromium-51-labeled post-transfusion red blood cell recovery method. Transfusion 2019; doi: 10.1111/trf.15310.
•   206. F Freedman R, Hunter SK, Law AJ, Wagner BD, D'Alessandro A, Christians U, Noonan K, Wyrwa A, Hoffman MC. Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development. J Pediatr. 2019;208:198-206.e2.
•   205. Henriksen HH, McGarrity S, Siguordottir RS, Nemkov T, D’Alessandro A, Stensballe J, Wade CE, Rolfsson O, Johansson PI. Metabolic systems analysis of shock induced endotheliopathy (SHINE) in Trauma – A new paradigm. Annals of Surgery 2019; in press
•   204. Gehrke S, Rice S, Stefanoni D, Wilkerson R, Nemkov T, Reisz JA, Hansen KC, Lucas A, Cabrales P, Drew K, D’Alessandro A. Red Blood Cell metabolic responses to torpor and arousal in the hibernator arctic ground squirrel. J Prot Res 2019; 18(4):1827-1841.
•   203. Gregory MA, Nemkov T, Park HJ, Zaberezhnvv V, Gehrke S, Adane B, Jordan CT, Hansen KC, D’Alessandro A, DeGregori J. Targeting glutamine metabolism and redox state for leukemia therapy. Clin Cancer Res. 2019; pii: clincanres.3223.2018. doi: 10.1158/1078-0432.CCR-18-3223.
•   202. D’Alessandro A, Reisz JA, Zhang Y, Gehrke S, Alexander K, Kanias T, Triulzi D, Donadee C, Barge S, Badlam J, Jain S, Belanger AM, Risbano MG, Gladwin MT. Effects of aged stored autologous red blood cells on human plasma metabolism. Blood Advances 2019; 3(6):884-896.
•   201. Pham-Danis C, Gehrke S, Danis E, Rohzok A, Daniels M, Gao D, Collins C, Di Paola J, D’Alessandro A, DeGregori J. EGFR inhibition promotes dependency on the urea cycle in EGFR mutant NSCLC. Mol Cancer Res 2018; doi: 10.1158/1541-7786.MCR-18-1068.
•   200.D’Alessandro A, Zimring JC, Busch M. Chronological storage age and metabolic age of stored red blood cells: are they the same? Transfusion. 2019;59(5):1620-1623.
•   199. D’Alessandro A. From omics technologies to personalized transfusion medicine. Exp Rev Prot 2019;16(3):215-225.
•   198. Clendenen N, Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D'Alessandro A, Moore HB. Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements. Blood Transfus. 2018; doi: 10.2450/2018.0188-18.
•   197. Rogers SC, Dosier LB, McMahon TJ, Zhu H, Timm D, Zhang H, Herbert J, Atallah J, Palmer G, Cook A, Ernst M, Prakesh H, Terng M, Towfighi P, Doctor R, Said A, Joens M, Fitzpatrick J, Hanna G, Lin X, Reisz JA, Nemkov T, D’Alessandro A, Doctor A. Red Blood Cell Phenotype Fidelity following Glycerol Cryopreservation Optimized for Research Purposes. PLoS One. 2018;13(12):e0209201.
•   196. Moore HB, D’Alessandro A, Moore EE, Wither M, Lawson P, Hansen K, Kam I, Wachs ME, Silliman CC, Banerjee A, Nydam T. Increase in post-reperfusion sensitivity to tissue plasminogen activator-mediated fibrinolysis during liver transplantation is associated with abnormal metabolic changes and increased blood product. Blood Transfus. 2019; doi: 10.2450/2019.0205-18.
•   195. Hoffman C, Olincy A, D’Alessandro A, Reisz JA, Hansen KC, Hunter SK, Freedman R, Ross RG. Effects of phosphatidylcholine and betaine supplements on women's serum choline. J Nutr Int Metabolism 2019;
•   194. Yoshida T, Prudent M, D’Alessandro A. Red blood cell storage lesion: causes and potential clinical consequences. Blood Transfus. 2019;17(1):27-52. *corresponding author
•   193. Lana A*, Alexander K, Castagna A, D'Alessandro A, Morandini F, Pizzolo F, Zorzi F, Mulatero P, Zolla L, Olivieri O. Urinary metabolic signature of primary aldosteronism: gender and subtype specific alterations. Proteomics Clinical Applicaitons 2019; doi: 10.1002/prca.201800049.*shared first authorship
•   192.   Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris IV JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp‐Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D’Alessandro A, Lowe SW, Prives C. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell 2019; 176(3):564-580.e19.
•   191.   Fox B, Hyo-Wook G, Griffin B, Jovanovich A, Soranno DE, Gist K, Haines JR, Wither M, D’Alessandro A, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney International 2019; 95(3):590-610.
•   190.   Soderborg TK, Mulligan CE, Clark SE, Babcock L, Janssen RC, Lemas DL, Johnson LK, Frank DN, Weir T, Baarbour LA, Hernandez TL, Kuhn KA, D’Alessandro A, El Kasmi KC, Friedman JE. The Gut Microbiome in Infants of Obese Mothers Increases Hepatic Inflammation and Susceptibility to Obesity and NAFLD in Germ-free Mice. Nature Communications 2019; accepted – waiting for doi
•   189.   Sheridan R, Fong N, D’Alessandro A, Bentley D. Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5' Pause Release, Termination, and Transcription Elongation Rate. Molecular Cell; 2019; Mol Cell. 2019 Jan 3;73(1):107-118.e4.
•   188.   Nemkov T, D’Alessandro A, Reisz JA. Metabolic underpinnings of leukemia pathology and treatment. Cancer Reports 2019; invited review

2018

187. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 Oct 26;9(1):4462.
186. Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D'Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Dec;18:25-41.
185. Nemkov T, Reisz JA, Xia Y, Zimring JC, D'Alessandro A. Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport. Expert Rev Proteomics. 2018 Nov;15(11):855-864.
184. Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Gladwin MT, Kleinman S, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D’Alessandro A. Methylation of aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Transfusion. 2018 Oct 12. doi: 10.1111/trf.14936.
183. D’Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo J, Page G, Gladwin M, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC. Heterogeneity of blood processing and storage additives in different centers impacts stored Red Blood Cell metabolism as much as storage time: lessons from REDS III – Omics. Transfusion 2018; waiting for doi
182. Jones CL, Stevens BM, D’Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Smith C, DeGregori J, Pollyea D, Jordan CT. Venetoclax + Azacytidine Disrupts Amino Acid Metabolism and Targets Leukemia Stem Cells. Nat Med. 2018 Nov 12. doi: 10.1038/s41591-018-0233-1.
181. Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D’Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbot D, Schatz D, Gutman JA, Purev E, Smith C, Jordan CT. The BCL-2 Inhibitor Venetoclax in Combination with Azacitidine Disrupts Energy Metabolism and Targets Leukemia Stem Cells in Acute Myeloid Leukemia Patients. Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005.
180.Rogers TJ, Green LI, Christenson JL, O’Neill K, Gordon M, Nemkov T, D’Alessandro A, Degala G, Shin J, Tan AC, Labmbert J, Torko K, Richer JK. microrna-200c regulates tryptophan catabolism, pd-l1, and other pathways of immune evasion in breast cancer. Mol Cancer Res. 2018 Sep 13. doi: 10.1158/1541-7786.MCR-18-0246.
179. Culp-Hill R, Srinivassan J, Gehrke S, Ansari A, Shah N, Welsby I, D’Alessandro A. Effects of red blood cell transfusion on sickle cell disease recipient plasma and erythrocyte metabolism. Transfusion. 2018 Sep 28. doi: 10.1111/trf.14931.
178. Stevens BM, Khan N, D’Alessandro A, Nemkov T, Winters A, Zhang W, Pollyea DA, Jordan CT. Characterization and Targeting of Emergent Acute Myeloid Leukemia (AML) Stem Cells in Patients with Myelodysplastic Syndromes (MDS). Nat Commun. 2018 Sep 12;9(1):3694
177. Greene L, Bruno TC, Christenson JL, D’Alessandro A, Culp-Hill R, Torkko K, Borges VF, Slansky JE, Richer JK. : A role for tryptophan 2,3-dioxygenase in CD8 T cell suppression and evidence of tryptophan catabolism in breast cancer patient plasma. Mol Cancer Therapeutics 2018; Accepted – waiting for doi
176. Klarquist JS, Chitrakar A, Pennock NA, Kilgore AM, Bla in T, Jiang L, Sun J, Hunter CA, D’Alessandro A, Keld RM. Vaccine-elicited T cell responses utilize IL-27 and IL-15 to support clonal expansion independent of aerobic glycolysis. Science Immunology 2018; Vol. 3, Issue 27, eaas9822; DOI: 10.1126/sciimmunol.aas9822
175. Karafin M, Fu X, D’Alessandro A, Thomas T, Hod E, Zimring JC, Field J, Francis RO. The Clinical Impact of Glucose-6-Phosphate Dehydrogenase Deficiency in Patients with Sickle Cell Disease. Curr Opin Hematol 2018; Accepted – waiting for doi
174. Catala A, Culp-Hill R, Nemkov T, D’Alessandro A. Quantitative metabolomics comparison of traditional blood draws and TAP capillary blood collection. Metabolomics 2018;
173. Paukovich N, Xue M, Elder JR, Redzic JS, Blue AS, Pike H, Miller BG, Pitts T, Pollock DD, Hansen KC, D’Alessandro A, Eisenmesser EZ. Biliverdin reductase B dynamics are coupled to coenzyme binding. J Mol Biol. 2018 Sep 14;430(18 Pt B):3234-3250.
172. Clendenen N, D’Alessandro A. High Throughput Metabolomics in Clinical Studies: application to remote ischemic preconditioning. Curr Topics In Medicinal Chem 2018; Accepted – waiting for doi
171. Zhang C, D’Alessandro A, Wellendorf A, Whitsett J, Perentesis J, Kumarov K, Stegmaier K, Grimes HL, Cancelas JA. KLF5 tumor suppressor activity of Ph+ B-cell acute lymphoblastic leukemia depends on activation of an anti-oxidant transcriptional program. Oncotarget 2018; Accepted waiting for doi
170. Faulds KJ, Egleston J, Sedivy LJ,Graimella S, Kozlowski H, D’Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ. A Role For Glycogen Synthase Kinase-3 (Gsk-3) in the Regulation of mRNA Methylation in Mouse Embryonic Stem Cells. Biochemistry 2018; J Biol Chem. 2018 Jul 6;293(27):10731-10743.
169. Graham B, Kumar R, Mickael C, Kassa B, Koyanagi D, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Loomis Z, Nemkov T, Irwin D, D’Alessandro A, Stenmark K, Tuder R. Vascular adaptation of the right ventricle in severe experimental pulmonary hypertension. Am J Respir Cell Mol Biol. 2018 May 31. doi: 10.1165/rcmb.2018-0095OC.
168. Zhang Y, Christian BE, Lee JH, Paull TT, Schroeder EA, Gehrke S, D’Alessandro A, Shadel G. Mitochondrial redox signaling by ATM regulates cellular antioxidant capacity. Sci Signal. 2018 Jul 10;11(538).
167. El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D’Alessandro A, Reisz JA, Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1b/NFkB signaling mediates Parenteral Nutrition Associated Cholestasis. Nature Communications 2018; 9(1):1393. doi: 10.1038/s41467-018-03764-1
166. D’Alessandro A, Reisz JA, Culp-Hill R, De Korte D, van Bruggen R. The (non-)commutative property of addition to red blood cell storage formulations: effects of alkaline additives and guanosine/gluconate. Transfusion 2018; doi: 10.1111/trf.14620.
165. Gehrke S, Srivanasan J, Culp-Hill R, Reisz JA, Ansari A, Alan Gray, Matthew Landrigan, Welsby I, D’Alessandro A. Cold bedside rejuvenation as an alternative rejuvenation practice. Transfusion. 2018. doi: 10.1111/trf.14623. *corresponding author
164. Banerjee A, Silliman CC, Moore EE, Dzieciatskowa M, Kelher M, Sauaia A, Jones K, Chapman MP, Gonzalez E, Moore HB, D'Alessandro A, Peltz E, Huebner BE, Einerson P, Chandler J, Ghasabayan A, Hansen K. Systemic Hyperfibrinolysis after Trauma: A Pilot study of Targeted Proteomic Analysis of Superposed Mechanisms in Patient Plasma. J Trauma Acute Care Surg. 2018 Mar 16. doi: 10.1097/TA.0000000000001878.
163. Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D'Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC. Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics. J Biol Chem. 2018 Mar 14. pii: jbc.RA117.000470.
162. Reisz JA, Barrett AS, Nemkov T, Hansen KC, D'Alessandro A. When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies. Expert Rev Proteomics. 2018 Mar 21:1-17. doi: 10.1080/14789450.2018.1453362.
161. Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D'Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539.
160. Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D'Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR. Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun. 2018;2(3):313-328.
159. Perreault L, Newsom S, Strauss A, Kerege A, Kahn T, Harrison K, Snell-Bergeon J, Nemkov T, D’Alessandro A, Jackman M, MacLean P, Bergman BC. Intracellular Localization of Diacylglycerols and Sphingolipids influence Insulin Sensitivity and Mitochondrial Function in Human Skeletal Muscle. JCI Insight 2018;3(3). pii: 96805. doi: 10.1172/jci.insight.96805.
158. Reisz JA, Tzounaka VL, Nemkov T, Voulgaridou AI, Papassideri IS, Kriebardis AG, D’Alessandro A, Antonelou MH. Metabolic linkage and correlations to storage capacity in erythrocytes from glucose 6-phosphate dehydrogenase deficient donors. Frontiers in Medicine 2018 Jan 11;
157. Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn S, Hess JR, Klein H, Acker J, Spinella P, D’Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon T, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration’s Public Workshop on New Red Blood Cell Product Regulatory Science 2016; Transfusion. 2018. doi: 10.1111/trf.14435.

113. D’Alessandro A*, Nemkov T, Sun K, Xia Y, Monte AA, Subudhi AW, Julian CG, Lovering AT, Dvorkin D, Kevil CG, Gladwin MT, Hansen KC, Roach RC. AltitudeOmics: Red Blood Cell metabolic adaptation to high altitude hypoxia. J Prot Res 2016; ;15(10):3883-3895* corresponding author
112. D’Alessandro A* Red blood cell storage lesion. Vox Sang ISBT Series 2016; DOI: 10.1111/voxs.12298 *corresponding author
111. Liu C, D’Alessandro A, Xia Y. Metabolomics approach in probing drug candidates. Curr Topics Med Res 2016; invited review DOI : 10.2174/1568026617666161116144146
110. Gregory M, D’Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Rohzok A, Kumar A, Kumar V, Wempe MF, Serkova N, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-dependent metabolic pathways promote mitochondrial redox homeostasis and resistance to FLT3 inhibition in acute myeloid leukemia. PNAS 2016; 113(43):E6669-E6678.
109. Paglia G, D’Alessandro A, Sigurjonsson O, Rolfsson O, Bordbar A, Gudmondsson S, Nemkov T, Hansen KC, BO. Biomarkers defining the metabolic age of red blood cells during cold storage. Blood 2016; 128(13):e43-50.
108. Gamboni F, Anderson C, Sanchayita M, Nemkov T, Dzieciatkowska M, Jones KL, Hansen KC, D’Alessandro A, Banerjee A. Hypertonic saline primes activation of the p53/p21 signaling axis in Small Airways Epithelial Cells that prevents inflammation induced by pro-inflammatory cytokines. J Prot Res 2016; 15(10):3813-3826.*corresponding author
107. Slaughter A, D’Alessandro A, Banerjee A, Silliman CC, Hansen KC, Haines J, Peltz ED, Fragoso M, Wither M, Bacon A, Moore HB, Moore EE. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma 2016; 81(6):1012-1019.
106. Li M, Riddle S, Zhang H, D’Alessandro A, Flockton A, Serkova N, Hansen KC, Moldvan R, Poth J, McKeon AB, Frid M, Li H, Liu H, Canovas A, Medrano J, Illoska D, Plecita-Hlavata L, Jezek P, Fini M, Pullamsetti S, El Kasmi KC, Zhang Q, Stenmark K. Glycolytic reprogramming regulates the proliferative and inflammatory phenotype of adventitial fibroblasts in pulmonary hypertension through the transcriptional co-repressor C-terminal Binding Protein-1. Circulation 2016; 134(15):1105-1121
105. Reisz JA, Wither M, Dzieciatkowska M, Issaian A, Hansen KC, D’Alessandro A*. Metabolic regulation through oxidation/ vesiculation of glyceraldehyde 3-phosphate dehydrogenase in red blood cells stored under blood bank conditions in additive solution 3. Blood 2016; 128(12):e32-42. *corresponding author
104. Tzounakas VL, Kriebardis AG, Georgatzakou H, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri I, D’Alessandro A,# and Marianna H. Antonelou#. Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Free Rad Biol Med 2016; ;8:618-27. d *corresponding author
103. Liu H, Zhang Y, Song A, Yegutkin GG, D’Alessandro A, Lee J, Cheng NY, Sun H, Kellems RE, Karmouty-Quintana H, Wen TT, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MK, Nemkov T, Hansen KC, Roach RC, Xia Y. Adenosine signaling via AMPK-induced erythrocyte oxygen release: a key mechanism for human hypoxia adaptation and novel therapy. Circulation 2016; ;134(5):405-21.
102. Sun K*, Zhang Y*, D’Alessandro A*, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Nemkov T, Hansen KC, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Vila A, O’Brien J, Roach RC, Yang X. Erythrocyte sphingosine 1 phosphate: a key intracellular modulator for adaptation to high altitude hypoxia. Nature Comm 2016; 7:12086. *shared first authorship
101. Tzounakas VL, Kriebardis AG, Georgatzakou H, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri I, D’Alessandro A,# Antonelou MH#. Storage of glucose 6-phosphate dehydrogenase deficient red blood cells . Free Rad Biol Med 2016; 96:152-65.. #corresponding authors
100. Newsom SA, Brozinick JT, Strauss AN, Bacon SD, Kerege AA, Hoang Bui H, Sanders P, Siddall P, Wei T, Thomas M, Shang Kuo M, Nemkov TG, D’Alessandro A, Hansen KC, Perreault L, Bergman BC. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and responsive to acute exercise in humans. J Appl Physiol 2016; 120(11):1355-63
99. Goodman SR, Pace BS, Hansen KC, D’Alessandro A, Xia Y, Daescu O, Glatt S. Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: early steps to precision medicine. Exp Biol Med 2016; 241(7):772-81.
98. Champagne DP, Hatle KM, Fortner KA, D’Alessandro A, Thornton TM, Yang R, Torralba D, Tomas-Cortazar J, Woong Jun Y, Han Ahn K, Hansen KC, Haynes L, Anguita J, Rincon M. Fine-tuning of CD8 T cell mitochondrial respiration by MCJ/DnaJC15 dictates protection to influenza virus. Immunity 2016; 44(6):1299-311.
97. D’Alessandro A*#, Moore HB*, Moore EE, Wither MJ, Nemkov T, Morton AP, Gonzalez E, Chapman MP, Fragoso M, Slaughter A, Sauaia A, Silliman CC, Hansen KC, Banerjee A. Plasma first resuscitation buffers metabolic derangement from profound shock. Shock 2016; 46(2):173-82. * shared first authorship #corresponding author
96. D’Alessandro A, Dzieciatkowska M. Hill R, Hansen KC. Supernatant protein biomarkers of red blood cell storage hemolysis as determined through an absolute quantification proteomics technology. Transfusion 2016; 56(6):1329-39.
95. Plecitá-Hlavatá L, TauberJ, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D’Alessandro A, El Kasmi KC, Ježek P, Stenmark KR. Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension. American Journal of Respiratory Cell and Molecular Biology 2016; 55(1):47-57.
94. D’Alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman C, Banerjee A, Hansen KC. Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma versus lymph. Blood Transfusion 2016; 14(2):185-94. * corresponding author
93. Nemkov T, Hansen KC, Ness P, Dumont LJ, D’Alessandro A*. Metabolomics in Transfusion Medicine. Transfusion 2016; 56(4):980-93. * corresponding author
92. D’Alessandro A. Leucoreduction of blood components: clinical and molecular evidence. Invited Commentary; Blood Transfusion 2016; ;14(2):212-3.
91. D’Alessandro A*,#, Nemkov T*, Hansen KC. Rapid detection of phthalate plasticizers in SAGM and AS-3 red blood cells. Blood Transfusion 2016; 14(2):140-4. *shared first authorship #corresponding author
90. Wither M, Dzieciatkowska M, Nemkov T, Strop P, D’Alessandro A*, Hansen KC. Hemoglobin oxidation at functional amino acid residues during routine storage of SAGM red blood cells. Transfusion 2016; 56(2):421-6. * corresponding author
89. Dumont LJ, D’Alessandro A, Szczepiorkowski Z, Yoshida T. CO2-dependent metabolic modulation in red blood cells stored under anaerobic conditions Transfusion 2016; 56(2):392-403.

2014

69. Cilli D, Mirasole C, Pennisi R, Pallotta V, D’Alessandro A, Antoccia A, Zolla L, Ascenzi P, Di Masi A. Proteomic identification of the interactors of NBN and of the 26 and 70 kDa fragments arising from the 657del5 founder mutation. PLOS One 2014; 9(12):e114651
68. D’Alessandro A, Dzieciatkowska M, Peltz E, Moore EE, Jordan JR, Banerjee A, Hansen KC. Dynamic Changes in Rat Mesenteric Lymph Proteins Following Trauma Using Label-Free Mass Spectrometry. Shock 2014; 42(6):509-17
67. D’Alessandro A, Amelio I, Berkers CR, Antonov A, Melino G, Vousden K, Zolla L. Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. Oncotarget. 2014;5(17):7722-33
66. Dzieciatkowska M*, D’Alessandro A*, Wohlauer M, Moore EE, Banerjee A, Hansen KC. Lymph is not a Plasma Ultrafiltrate: A Proteomic Analysis of Injured Patients. Shock 2014; 42(6):485-98. * shared first authorship
65. Cialfi S, Palermo R, Manca S, De Blasio C, Vargas Romero P, Checquolo S, Bellavia D, Uccelletti D, Saliola M, D’Alessandro A, Zolla L, Gulino A, Screpanti I, Talora C. Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis. Cell Cycle 2014; 13(13):2046-55.
64. Longo V, D’Alessandro A, Zolla L. Deoxygenation of leukofiltered erythrocyte concentrates preserves proteome stability during storage in the blood bank Blood Transfusion 2014; 12(4):599-604.
63. Prudent M, D’Alessandro A, Cazenave JP, Devine DV, Gachet C, Greinacher A, Lion N, Schubert P, Steil L, Thiele T, Tissot JD, Völker U, Zolla L. Proteome changes in platelets after pathogen inactivation--an interlaboratory consensus. Transfus Med Rev. 2014;28(2):72-83.
62. D’Alessandro A, Cervia D, Catalani E, Gevi F, Zolla L, Casini G. A metabolomic analysis of the protective effects of neuropeptides in retinal ischemia. Molecular Biosystems 2014; 10(6):1290-304.
61. Olivieri O, Cecconi D, Castagna A, Chiecchi L, Guarini P, Gunasekaran M, Morandini F, Brazzarola P, Zolla L, D’Alessandro A, Veglio F, Mulatero P, Pizzolo F. Urinary protease inhibitor Serpin B3 is higher in women and is further increased in female patients affected by aldosterone producing adenoma. Mol Biosystems 2014; 10(6):1281-9.
60. Pallotta V, Gevi F, D’Alessandro A, Zolla L.Red blood cell storage with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview. Blood Transfusion 2014;12(3):376-87.
59. Pallotta V, Naro F, Gevi F, D’Alessandro A, Zolla L. Supplementation of anti-oxidants in leukofiltered erythrocyte concentrates: assessment of morphological changes through scanning electron microscopy. Blood Transfusion 2014;12(3):421-4.

2015

88. D’Amato N, Rogers T, Gordon M, Green L, Chocrane D, Spolestra N, Nemkov T, D’Alessandro A, Hansen KC, Richer J. A TDO2-AhR Signaling Axis Is Upregulated in Suspension and Regulates Metastatic Phenotypes in Triple-Negative Breast Cancer. Cancer Res 2015; 75(21):4651-64.
87. Moore HB, Moore EE, Chapman MP, Gonzalez E, Slaughter AL, Morton AP, D’Alessandro A, Hansen KC, Sauaia A, Silliman CC, Banerjee A. Viscoelastic measurements of platelet function not fibrinogen function predicts sensitivity to tissue plasminogen activator in trauma patients. J Thrombosis Hemostasis 2015; 13(10):1878-87.
86. D’Alessandro A*, Slaughter A*, Wither M, Nemkov T, Fragoso M, Pelttz ED, Hansen KC, Banerjee A. Hemorrhagic shock exacerbates plasma metabolic derangement primed by trauma: a preliminary 13C-glucose labeling experiment on a well-established rat model of trauma/hemorrhagic shock. J Translational Medicine 2015, 5;13:253. *shared first authorship
85. Mosher J, Zhang W, Blumhagen RZ, D’Alessandro A, Nemkov T, Hansen KC, Hesselberth JR, Reis T. Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat. Developmental Biology 2015; 405(2):280-90.
84. D’Alessandro A, Nemkov T, Hansen KC, Szczepiorkowski ZM, Dumont LJ. Red Blood Cell storage in Additive Solution-7 preserves energy and redox metabolism: a metabolomics approach. Transfusion 2015; 55(12):2955-66.
83. Nemkov T*, D’Alessandro A*, Hansen KC. A3: Three minute method for amino acid analysis. Amino Acids 2015; 47(11):2345-57. *shared first authorship
82. Hill R, Wither M, Dzieciatkowska M, Nemkov T, Barrett A, D’Alessandro A, Hansen K. Preserved protein from extinct Bison latifrons identified by Tandem Mass Spectrometry. Mol Cell Prot 2015; 14(7):1946-58
81. D’Alessandro A*, Moore HB, Wither M, Nemkov T, Gonzalez E, Fragoso M, Banerjee A, Hansen KC, Silliman CC, Moore EE. Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Reg Integr Comp Physiol 2015; ;308(12):R1034-44. *corresponding author
80. Hansen KC, D’Alessandro A, Clement CC, Santambrogio L. Lymph formation composition and circulation: a proteomics perspective. International Immunol 2015; 27(5):219-227.
79. Dzieciatkowska M, D’Alessandro A, Hill RC, Hansen KC. Plasma QConCATs reveal a gender-specific proteomic signature in apheresis platelet plasma supernatants. J Proteomics 2015; 120:1-6.
78. Taamalli M,* D’Alessandro A*, Marrocco C, , Abdelly C, Zolla L. Cadmium stress responses in the halophyte Cakile maritima Molecular BIosystems 2015; 11(4):1096-109. * shared first authorship
77. Wiener G, Moore HB, Moore EE, Gonzalez E, Diamond S, Zhu S, D’Alessandro A, Banerjee A. Shock Releases Bile Acid Attributable to Platelet Inhibition and Fibrinolysis. J Surgical Res 2015; 195(2):390-5.
76. Peltz E*, D’Alessandro A*, Moore E, Chin T, Silliman C, Sauaia A, Hansen KC, Banerjee A. Pathologic Metabolism: The Plasma Metabolome of Critical Injury. J Trauma Acute Care Surgery 2015; 78(4):742-51. *shared first authorship
75. Zolla L, D’Alessandro A, D’Amici GM, Rinalducci S, Pupella S, Grazzini G, Vaglio S. Classic and alternative Red blood cell storage strategies: Seven years of Omics investigations. Blood Transfusion 2015; 13: 21-31.
74. D’Alessandro A*,#, Nemkov T, Kelher M, West B, Schwindt R, Moore EE, Banerjee A, Silliman CC, Hansen KC. Routine Storage of Red Blood Cell Units in Additive Solution-3: a comprehensive investigation of the RBC metabolome Transfusion 2015; 55(6):1155-68. * corresponding author
73. D’Alessandro A,#, Kriebardis A, Rinalducci S, Antonelou M, Hansen KC, Papassideri I, Zolla L. An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies. Transfusion 2015; 55(1):205-19.
72. D’Alessandro A, Hansen KC, Silliman C, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants Vox Sanguinis 2015; 108(2):131-40
71. Lana A, Longo V, Dalmasso A, D’Alessandro A, Bottero MT, Zolla L. Extended hanging period promotes Piedmontese beef tenderness without compromising meat safety. Food chemistry 2015; 172(731):741.
70.Dzieciatkowska M,* D’Alessandro A*, Moore EE, Banerjee A, Hansen K, Silliman CC. Proteomics of apheresis platelet supernatants during storage in the blood bank: gender-related differences. J Proteomics 2015; 112C:190-209. *shared first authorship

2012

41. Zolla L, D’Alessandro A. Preface to the Special Issue Integrated Omics. J Proteomics 2012; 76:3-9.
40. Polati R, Castagna A, Bossi AM, Alberio T, De Domenico I, Kaplan J, Timperio AM, Zolla L, Federica G, D’Alessandro A, Brunch R, Olivieri O, Girelli D. Murine macrophages response to iron. J Proteomics 2012; 76:10-27.
39. Zolla L, D’Alessandro. Shaking hands with the future through Omics application in Transfusion Medicine and Clinical Biochemistry. Preface.Blood Transfusion 2012; 10(2):s1-3.
38. D’Alessandro A, Gevi F, Timperio AM, Giardina B, Zolla L. Clinical Metabolomics: the next stage of clinical biochemistry. Blood Transfusion 2012; 10(2):s19-24.
37. D’Amici GM, Mirasole C, D’Alessandro A, Yoshida T, Dumont LJ, Zolla L. Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome. Blood Transfusion 2012; 10(2):s46-54.
36. Marrocco C, Pallotta V, D’Alessandro A, Gilda A, Zolla L. Red blood cell populations and membrane levels of peroxiredoxin 2 as candidate biomarkers to reveal blood doping. Blood Transfusion 2012; 10(2):s71-7.
35. D’Alessandro A, Marrocco C, Rinalducci S, Mirasole C, Failla S, Zolla L. Chianina beef tenderness investigated through integrated Omics. J Proteomics 2012; 75(14):4381-98.
34. D’Alessandro A, Zolla L. Food safety and quality control: hints from proteomics. Food Technol Biotechnol 2012; 50(3):275-85.
33. Gevi F*, D’Alessandro A*, Rinalducci S, Zolla L. Alterations of Red Blood Cell metabolome during cold liquid storage of erythrocyte concentrates in CPD-SAGM. J Proteomics. 2012; 76:168-180. *shared first authorship
32. D’Alessandro A, Rinalducci S, Marrocco C, , Zolla V, Napolitano F, Zolla L. Love me tender: an omics window on the Maremmana meat tenderness network. J Proteomics 2012; 75(14):4360-80.
31. Blasi B, D’Alessandro A, Nicola Ramundo, Zolla L. Red blood cell storage and cell morphology.Transfusion Medicine 2012; 22(2):90-6.
30. Blasi B, D’Amici GM, D’Alessandro A, Zolla L. Native analysis of Plasma-derived clotting factor VIII concentrates: “sponge effect” and contaminants. Electrophoresis 2012; 33:1-7.
29. Pallotta V, D’Amici GM, D’Alessandro A, Rossetti R, Zolla L. Monitoring of red blood cells during processing for cryopreservation: from fresh blood to thaw-washing. Blood Cells, Molecules and Diseases 2012; 48(4):226-32.
28. D’Alessandro A, Zolla L. We are what we eat: food safety and proteomics. J Proteome Res 2012; 11(1):26-36.
27. D’Alessandro A, Gevi F, Palini S, Bulletti C, Zolla L. A mass spectrometry-based targeted metabolomics strategy of human blastocoele fluid: a promising tool in fertility research. Mol Biosyst. 2012 Apr;8(4):953-8.
26. D’Alessandro A, D’Amici GM, Vaglio S, Zolla L. Time-course Investigation of SAGM-Stored Erythrocyte Concentrates: from Metabolism to Proteomics. Hematologica 2012 ;97(1):107-15.
25. D’Alessandro A, Zolla L. Metabolomics and cancer drug discovery: let the cells do the talking. Drug Discov Today 2012; 17(1-2):3-9.
24. Timperio AM, D’Alessandro A, Fagioni M, Zolla L. Production of the phytoalexin trans-resveratrol and delta-viniferin in two economy-relevant grape cultivars upon infection with Botrytis cinerea in field conditions. Plant Physiology Biochemistry 2012; ;50(1):65-71.
23. D’Alessandro A, Gevi F, Zolla L. Targeted mass spectrometry-based metabolomic profiling through Multiple Reaction Monitoring of Liver and other biological matrices. Methods Mol Biol. 2012; In Liver Proteomics. In Methods and Protocols Series: Methods in Molecular Biology. 2012; vol. 909. Josic, Djuro; Hixson, Douglas C. (Eds.)

2011

22. D’Alessandro A, Marrocco C, Zolla V, D’Andrea MS, Zolla L. Meat quality and the Longissimus lumborum muscle of Casertana and Large White pigs: metabolomics and proteomics intertwined. J Proteomics 2011;75(2):610-27.
21. D’Amici GM, Blasi B, D’Alessandro A, Vaglio S, Zolla L. Plasma-derived clotting factor VIII: heterogeneity evaluation in the quest for potential inhibitory-antibody stimulating factors. Electrophoresis 2011; 32: 1-10.
20. D’Alessandro A, D’Amici GM, Timperio AM, Merendino N, Zolla L. Docosohaexanoic acid-treated PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomics, metabolomics and interactomics overview. J Proteomics. 2011;74(10):2138-58.
19. Basco D, Nicchia GP, D’Alessandro A, Zolla L, Svelto M, Frigeri A. Absence of AQP4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling. PLOS ONE 2011; 6(4):e19225.
18. D’Alessandro A, Zolla L. The SODyssey – Superoxide dismutases: from biochemistry, through proteomics, to oxidative stress, ageing and nutraceuticals. Exp Rev Proteomics. 2011; 8(3):405-21.
17. D’Alessandro A, Gevi F, Zolla L. A robust high resolution reversed-phase HPLC strategy to investigate various metabolic species in different biological models. Mol Biosyst. 2011; 7(4):1024-32.
16. D’Alessandro A, Rinalducci S, Zolla L. Redox proteomics and drug development. J Proteomics. 2011; 74(12):2575-95
15. D’Alessandro A, Zolla L, Scaloni A. The bovine milk proteome: cherishing, nourishing and fostering molecular complexity. An interactomics and functional overview. Mol Biosyst. 2011;7(3):579-97

2010

14. D’Alessandro A, Zolla L. Pharmacoproteomics: a chess game on a protein field. Drug Discov Today. 2010;15(23-24):1015-23.
13. Murgiano L, D’Alessandro A, Egidi MG, Crisà A, Prosperini G, Timperio AM, Valentini A, Zolla L. Proteomics and transcriptomics investigation on longissimus muscles in Large White and Casertana pig breeds. J Proteome Res. 2010;9(12):6450-66
12. D’Alessandro A, Grazzini G, Giardina B, Zolla L. In silico analyses of proteomic data suggest a role for heat shock proteins in umbilical cord blood hematopoietic stem cells. Stem Cell Rev. 2010;6(4):532-47.11. Egidi MG, D’Alessandro A, Mandarello G, Zolla L. Troubleshooting in platelet storage temperature and new perspectives through proteomics. Blood Transfus. 2010;8 Suppl 3:s73-81
10. D’Alessandro A, Zolla L. Proteomics for quality-control processes in transfusion medicine. Anal Bioanal Chem. 2010;398(1):111-24
9. D’Alessandro A, Scaloni A, Zolla L. Human milk proteins: an interactomics and updated functional overview. J Proteome Res. 2010;9(7):3339-73.
8. D’Alessandro A, Liumbruno G, Grazzini G, Zolla L. Red blood cell storage: the story so far. Blood Transfus. 2010;8(2):82-8.
7. Liumbruno G, D’Alessandro A, Grazzini G, Zolla L. How has proteomics informed transfusion biology so far? Crit Rev Oncol Hematol. 2010;76(3):153-72.
6. Liumbruno GM, D’Alessandro A, Rea F, Piccinini V, Catalano L, Calizzani G, Pupella S, Grazzini G. The role of antenatal immunoprophylaxis in the prevention of maternal-foetal anti-Rh(D) alloimmunisation. Blood Transfus. 2010;8(1):8-16.
5. D’Alessandro A, Righetti PG, Fasoli E, Zolla L. The egg white and yolk interactomes as gleaned from extensive proteomic data. J Proteomics. 2010;73(5):1028-42.
4. D’Alessandro A, Righetti PG, Zolla L. The red blood cell proteome and interactome: an update. J Proteome Res. 2010;9(1):144-63.
3. Timperio AM, D’Alessandro A, Pariset L, D'Amici GM, Valentini A, Zolla L. Comparative proteomics and transcriptomics analyses of livers from two different Bos taurus breeds: "Chianina and Holstein Friesian". J Proteomics. 2009;73(2):309-22.
2. Liumbruno G, D’Alessandro A, Grazzini G, Zolla L. Blood-related proteomics. J Proteomics. 2010;73(3):483-507.
1. D’Alessandro A, Liumbruno G, Grazzini G, Pupella S, Lombardini L, Zolla L. Umbilical cord blood stem cells: towards a proteomic approach. J Proteomics. 2010;73(3):468-82.

BOOK CHAPTERS

Zolla L, D’Alessandro A. Proteomic Investigations on Stored Red Blood Cells. In Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood. Mozzarelli A. Editor; John Wiley and Sons Ltd The Atrium, Southern Gate Chichester, West Sussex, PO19 8SQ
D’Alessandro A*, Zolla L. Biochemistry of red cell aging in vivo and storage lesions. Hematology Education: the education programme for the annual congress of the European Hematology Association 2013; 7(1):389-396 *corresponding author
Plecita-Hlavata L, D'Alessandro A, El Kasmi K, Li M, Zhang H, Jezek P, Stenmark KR. Metabolic reprogramming and redox signaling in pulmonary hypertension. in Pulmonary Vascular redox Signaling in Health and Disease. Edited by Yong-Xiao Wang. Advances in Experimental Medicine and Biology. Springer 2017
•   225. D’Alessandro A. Preface. Meth Mol Biol; 2019 – High-throughput Metabolomics – D’Alessandro Editor. Springer Nature. ISSN: 978-1-4939-9235-5
•   224. Reisz JA, Zheng C, D’Alessandro A, Nemkov T. Untargeted and semi-targeted lipid analysis of biological samples using mass spectrometry-based metabolomics. Meth Mol Biol; 2019 – High-throughput Metabolomics – D’Alessandro Editor. Springer Nature. ISSN: 978-1-4939-9235-5
•   223. Nemkov T, Reisz JA, Gehrke S, Hansen KC, D’Alessandro A. High-throughput metabolomics: isocratic and gradient mass spectrometry-based methods. Meth Mol Biol; 2019 – High-throughput Metabolomics – D’Alessandro Editor. Springer Nature. ISSN: 978-1-4939-9235-5

2017

156. Mitra S, Schiller D, Anderson C, Gamboni F, D'Alessandro A, Kelher M, Silliman CC, Banerjee A, Jones KL. Hypertonic saline attenuates the cytokine-induced pro-inflammatory signature in primary human lung epithelia. PLoS One. 2017;12(12):e0189536.
155. Culp-Hill R, Zheng C, Reisz JA, Nemkov T, Hansen KC, D’Alessandro A. Red blood cell metabolism in Down Syndrome. Blood Adv. 2017 Dec 21;1(27):2776-2780.
154. Nemkov T, Sun K, Reisz JA, Song A, Yoshida T, Dunham A, Wither MJ, Francis RO, Roach RC, Dzieciatkowska M, Rogers SC, Doctor A, Kriebardis A, Antonelou M, Papassideri I, Hansen KC, Spitalnik SL, Xia Y, Zimring JC, Hod EA, D’Alessandro A*. Hypoxia modulates the purine salvage pathway and decreases cell and supernatant levels of hypoxanthine, a predictor of 24h in vivo survival of stored mouse and human red blood cells. Haematologica 2017; doi: 10.3324/haematol.2017.178608. *corresponding author
153. Plecita-Hlavata L, D’Alessandro A, El Kasmi K, Zhang H, Jezek P, Stenmark KR. Metabolic reprogramming and redox signaling in pulmonary hypertension. Adv Exp Biol Med 2017; doi: 10.1007/978-3-319-63245-2_14
152. Nemkov T, Sun K, Reisz JA, Yoshida T, Dunham A, Roach RC, Hansen KC, Xia Y, D’Alessandro A. Metabolism of citrate and other carboxylic acids in erythrocytes as a function of oxygen saturation and refrigerated storage. Frontiers in Medicine 2017; doi: 10.3389/fmed.2017.00175
151. Reisz JA, Wither MJ, Moore EE, Moore HB, Slaughter AL, Ghasabyan A, Chandler J, Schaub L, Fragoso M, Nunns G, Silliman CC, Hansen KC, Banerjee A, Sheppard FR, D’Alessandro A*. All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhaged rats, pigs, non-human primates and clinical patients. J Trauma 2017; doi: 10.1097/TA.0000000000001721.*corresponding author
150. Sun K, D’Alessandro A, Zhang Y, Song A, Nemkov T, Reisz J, Wu H, Adebyi M, Liu H, Huang A, Peng Z, Wen YE, Wen QE, Berka V, Bogdanov M, Abdulmalik O, Thai AI, Kellems RE, Dowan W, Hansen KC, Safo M, Xia Y. Structural and functional mechanisms of Sphingosine 1 Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Scientific Reports 2017; doi: 10.1038/s41598-017-13667-8.
149. Barrett AS, Wither MJ, Hill RC, Dzieciatkowska M, D’Alessandro A, Reisz JA, Hansen KC. Hydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization. J Prot Res 2017; 16(11):4177-4184
148. Gregory M, Nemkov T, Reisz JA, Hansen KC, D’Alessandro A, Degregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol 2017; doi: 10.1016/j.exphem.2017.09.007
147. Zhang H, Riddle S, Li M, D’Alessandro A, El Kasmi K, Stenmark K. The role of CTBP1/miR-124/PKM2 signaling axis in metabolic reprogramming of pulmonary hypertension. Circulation 2017; doi: 10.1161/CIRCULATIONAHA.117.028069
146. Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton A, Frid MG, Kiskin FN, Hurst L, Ormiston ML, Hata A, D’Alessandro A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Identification of miR-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension by miRNA and proteomic profiling. Circulation 2017; doi: 10.1161/CIRCULATIONAHA.117.028034
145. Culp-Hill R, Reisz JA, Hansen KC, D’Alessandro A. Investigation of the effects of storage and freezing on mixes of heavy-labeled metabolite and amino acid standards. Rapid Comm Mass Spectrometry 2017; 31(23):2030-2034.
144. Henry CJ, Nemkov T. Casas-Selves M, Bilousova G, Zaberezhnyy V, Higa K, Serkova NJ, Hansen KC, D’Alessandro A, DeGregori J. Deficient and Excessive Dietary Folate Levels Similarly Impact Metabolism and Compromise Hematopoiesis. Haematologica 2017; doi: 10.3324/haematol.2017.171074.
143. Thwe P, Beauchamp S, Reisz J, D’Alessandro A, Amiel E. Cell-intrinsic glycogen metabolism supports early glycolytic reprogramming associated with dendritic cell immune effector function. Cell Metabolism 2017; 26(3):558-567.e5.
142. Slaughter A*, Nunns G, D’Alessandro A, Banerjee A, , Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Wither M, Leasia K, Peltz ED. The Metabolopathy of Tissue Injury, Hemorrhagic Shock and Resuscitation in a Rat Model. Shock 2017; doi: 10.1097/SHK.0000000000000948
141. Hazegh KE, Nemkov T, D’Alessandro A, Monks J, Bales E, McManaman J, Hansen KC, Reis T. An autonomous metabolic role for Split Ends. PLOS Genetics 2017; 13(6):e1006859.
140. Sun K, Liu H, Song A, Manalo JM, D’Alessandro A, Hansen KC, Kellems RE, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Erythrocyte Purinergic Signaling Components Underlies Hypoxia Adaptation. J Appl Physiol 2017; 123(4):951-956.
139. D’Alessandro A, Moore HB, Reisz J, Hansen KC, Silliman C, Banerjee A, Moore EE. Plasma succinate is a predictor of mortality in critically injured patients. J Trauma 2017; 83(3):491-495. * corresponding author
138. Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Hansen KC, Banerjee A, Moore HB, D’Alessandro A*. Hemorrhagic Shock, not Poly-Trauma, Drives the Plasma Metabolome Derangement in Pigs. J Trauma 2017; 83(4):635-642
137. D’Alessandro A, Grayk E, Stenmark KR. Identification of Infants at Risk for Chronic Lung Disease at Birth: Potential for a Personalized Approach to Disease Prevention. Am J Crit Resp Care Med Blue 2017; 196(8):951-952.
136. Reisz JA, Slaughter A, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D’Alessandro A*. Red Blood Cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination reactions in rats. Blood Advances 2017; 1:1296-1305. *corresponding author
135. Gehrke S, Reisz JA, Nemkov T, Hansen KC, D’Alessandro A*. Characterization of rapid extraction protocols for high-throughput metabolomics. Rapid Comm Mass Spectrometry 2017; 31(17):1445-1452. *corresponding author
134. Reisz JA, D’Alessandro A*. Measurements of metabolic fluxes using stable isotope tracers in whole animals and human patients. Curr Opinion in Clin Nutr Metabolic Care 2017; 20(5):366-374. *corresponding author
133. Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey A, Danhorn T, Leach S, Fingerlin T, O’Connor B, Reisz J, D’Alessandro A, Bratton D, Jakubzick C, Henson P, Janssen WJ. Resident And Recruited Alveolar Macrophages Exhibit Distinct Immunometabolic Programs In The Inflamed Alveolus. Am J Resp Cell Mol Biol 2017; 57(3):294-306.
132. D’Alessandro A, Plecita-Hlavata L, El Kasmi K, Li M, Zhang H, Jezek P, Stenmark KR. Hallmarks of pulmonary hypertension. Antioxidant Redox Signaling 2017; doi: 10.1089/ars.2017.7217.
131. Sun K, D’Alessandro A, Xia Y. Red blood cell storage and purinergic signaling. Blood Transfuion 2017; 15(6):535-542.
130. Nemkov T, Hansen KC, D’Alessandro A* Three Minute Method for high-throughput quantitative metabolomics and quantitative flux-analysis of central carbon and nitrogen pathways. Rapid Comm Mass Spectrometry 2017; 31(8):663-673. *corresponding author
129. D’Alessandro A, Liumbruno GM. Editorial. Red blood cell storage and clinical trials. Blood Transfusion 2017; 15(2):101-103.
128. D’Alessandro A, Seghatchian J. Hitchhiker’s guide to the red blood cell storage galaxy. Transfusion Science 2017; 56(2):248-253.
127. D’Alessandro A, Zolla L. Red blood cell proteomics for clinical applications. Exp Rev Prot 2017; 14(3):243-252. *corresponding author
126. Clendenen N, Toellfson A, Dzieciatkowska M, Cambiaghi A, Ferrario M, Kroehl M, Banerjee A, D’Alessandro A, Hansen KC, Weitzel N. Discovery phase of coagulation profile testing in cardiac surgery using QconCAT proteomics technology. Proteomics Clin Appl 2017; 11(7-8).
125. Cavalli G, Justice JN, Boyle KE, D’Alessandro A, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Dagna L, Joosten LAB, Seals DR, Ballak DB, Dinarello C. Treatment with recombinant IL-37 ameliorates inflammation induced-fatigue and improves exercise tolerance: Dual mode of action via modulation of anti-inflammatory and metabolic pathways. PNAS 2017; 114(9):2313-2318.
124. Yoshida T, Blair A, D’Alessandro A, Dioguardi M, Silliman CC, Dunham A. Enhancing uniformity and overall quality of RCC with anaerobic storage. Blood Transfusion 2017; 15(2):172-181.
123. D’Alessandro A, Nemkov T, Reisz J, Dzieciatkowska M, Wither MJ, Hansen KC. Omics markers of the red cell storage lesion and metabolic linkage. Blood Transfusion 2017; 15(2):137-144.
122. D’Alessandro A, Szczepiorkowski Z, Gray AD, Dumont LJ. Metabolomics of outdated red blood cells upon rejuvenation-freezing/thawing/deglycerolization and 4C overnight hold after 24h refrigerated storage. Transfusion 2017; 57(4):1019-1030.
121. Pei S, Minhajuddin M, D’Alessandro A, Nemkov TG, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Jordan CT. Rational design of therapeutic regimens that selectively target acute myelogenous leukemia stem cells. J Biol Chem 2017; 291(48):25280.
120. D’Alessandro A, Nemkov T, Martin S, Hansen KC. Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.. J Prot Res 2017 16(2):958-969. *corresponding author
119. Kendrick A, Shaffer J, Dzieciatkowska M, Nemkov T, D’Alessandro A, Neelakantan D, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147 reprograms pancreatic cancer metabolism via its interaction with multiple small molecule transporters. Oncotarget 2017; 8(4):6742-6762.
118. Goddard E, Hill RC, Nemkov T, D’Alessandro A, Hansen KC, Maller O, Borges V, Schedin P. Weaning induced liver involution and the metastatic niche. Cancer Discovery 2017; 7(2):177-187.
117. Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D’Alessandro A, Lee J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC0, Xia Y. Erythrocytes retain “hypoxic purinergic memory” for faster acclimatization upon re-ascent. Nat Comm 2017; 8:14108.
116. Reisz JA, Chessler KM, Dzieciatkowska M, D’Alessandro A*, Hansen KC. Blood and plasma proteomics: targeted quantitation and post-translational redox modifications. Meth Mol Biol 2017; 1619:353-371. *corresponding author
115. D’Alessandro A, Dzieciatkowska M, Nemkov T, Hansen KC. A Red blood cell proteomics update- is there more to discover? Blood Transfusion 2017; 15(2):182-187.
114. D’Alessandro A*, Nemkov T, Yoshida T, Bordbar A, Palsson BO, Hansen KC, Quantitative metabolic flux analysis of red blood cells stored in Additive Solution-3 reveals unappreciated metabolism of other substrates than glucose. Transfusion 2017; ;57(2):325-336. *corresponding author

2016

2013

58. D’Alessandro A*, Taamalli M*, Gevi F, Timperio AM, Ghnaya T*, Zolla L. Cadmium stress responses in Brassica juncea: hints from proteomics and metabolomics Journal of Proteome Research 2013; 12(11):4979-97. *shared first authorship
57. D’Alessandro A, Zolla L. Proteomics, Metabolomics and Cancer Drug Development. Exp Rev Prot 2013; 10(5):473-88.
56. D’Alessandro A, Marrocco C, Rinalducci S, Peschiaroli A, Timperio AM, Bongiorno-Borbone L, Finazzi Agrò A, Melino G, Zolla L. Analysis of TAp73-dependent signaling via omics technologies. Journal of Proteome Research 2013; 12(9):4207-20.
55. Pallotta V, D’Alessandro A, Rinalducci S, Zolla L. Native protein complexes in the cytoplasm of Red Blood Cells. J Proteome Res 2013;12(7):3529-46.
54. D’Alessandro A, Zolla L. Foodomics to investigate meat tenderness. Trends in Analytical Chemistry 2013; 52:47-53
53. Dando I, Donadelli M, Costanzo C, Dalla Pozza E, D’Alessandro A, Zolla L, Palmieri M. Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells. Cell Death and Diseases 2013; 4:e664. doi: 10.1038/cddis.2013.151
52. Timperio AM, Mirasole C, D’Alessandro A, Zolla L. Red Blood Cell Lipidomics analysis through HPLC-ESI-qTOF: application to red blood cell storage. J Integrated Omics 2013; DOI: 10.5584/jiomics.v2013i2013.123
51. Zolla L, D’Alessandro A, Parguina A, Garcia A. In reply to “Response to reply –response “Platelet Proteomics in Transfusion Medicine: a reality with a challenging but promising future” Blood Transfusion 2013; 11: 316
50. D’Alessandro A, Gevi F, Zolla L. Red blood cell metabolism under prolonged anaerobic storage. Molecular Biosystems 2013; 9(6):1196-209.
49. Zolla L, D’Alessandro A. An efficient apparatus for rapid deoxygenation of erythrocyte concentrates for alternative banking strategies. J Blood Transfusion 2013; 2013:896537.
48. D’Alessandro A, Mirasole C, Zolla L. Hemoglobin alpha glycation (Hb1Ac) increases during red blood cell storage: a MALDI-TOF mass spectrometry-based investigation. Vox Sanguinis 2013; 105(2):177-80.
47. Marrocco C, D’Alessandro A, Rinalducci S, Rebulla P, Zolla L. The IPTAS study: the effects of pathogen inactivation technology Mirasol on apheresis platelet concentrates. Transfusion 2013; 53(8):1808-20.
46. Peschiaroli A, Giacobbe A, Formosa A, Markert EK, Bongiorno-Borbone L, Levine AJ, Candi E, D’Alessandro A, Zolla L, Finazzi Agrò A, Melino G. MIR-143 regulates hexokinase 2 expression in cancer cells. Oncogene 2013; 32: 797-802.
45. D’Alessandro A, Zolla L. Meat science: from Proteomics to Integrated Omics towards System biology. J Proteomics 2013; 78:558-577.
44. D’Alessandro A, Blasi B, D’Amici GM, Marrocco C, Zolla L. Red blood cell populations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue. Blood Transfusion; 2013;11: 75-87.
43. Murgiano L, D’Alessandro A, Zolla L, Valentini A, Pariset L. Comparison of Milk Fat Globule Membrane (MFGM) Proteins in Milk Samples of Chianina and Holstein Cattle Breeds across three Lactation Phases through 2D IEF SDS PAGE – a preliminary study. Food Research International 2013; 54(1):1280-1286.
42. Zolla L, D’Alessandro A. Response to "Platelets proteomics in Transfusion Medicine: a reality with challenging but promising future". Blood Transfusion 2013;11(2):316.

ENCYCLOPEDIA CHAPTERS

Zolla L, D’Alessandro A. Chromatography of Membrane Proteins and Lipoproteins. Encyclopedia of Analytical Chemistry. 2011. R.A. Meyers (Ed.) Copyright John Wiley & Sons Ltd. DOI: 10.1002/9780470027318.a1607.pub2
D’Alessandro A, Scaloni A, Zolla L. Human milk proteins: strides in proteomics and benefits in nutrition research. In “Dietary and Nutritional Aspects of Human Breast Milk‏” – Book Chapter – cured by Dr Sherma Zibadi, Prof Ronald R Watson and Prof Victor R Preedy; Human health handbooks - 2212-375X, Volume 5. Wageningen Academic Publisher 2014; ISBN: 978-90-8686-209-2
Zolla L, D’Alessandro A, Lana A. Chromatography of Membrane Proteins and Lipoproteins. Peptides and Proteins Encyclopedia of Analytical Chemistry. Update; 2016. R.A. Meyers (Ed.) Copyright John Wiley & Sons Ltd. Waiting for doi

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