Research Catalyst
ISSUES EDITED
Small - Cover
October 2020
Transfusion - Cover
October 2019
Circulation Research - Cover
July 2020
Cell Metabolism - Cover
2022
PUBLICATIONS highlights in red
2022
.403: Moore A, Busch MP, Dziewulska K, Francis RO, Hod EA, Zimring JC, D'Alessandro A, Page GP. Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors. J Biol Chem. 2022 Nov 14:102706. doi: 10.1016/j.jbc.2022.102706. Epub ahead of print. PMID: 36395887.
402: Schaid TR Jr, Cohen MJ, D'Alessandro A, Silliman CC, Moore EE, Sauaia A, Dzieciatkowska M, Hallas W, Thielen O, DeBot M, Cralley A, LaCroix I, Erickson C, Mitra S, Banerjee A, Jones K, Hansen KC. Trauma Induces Intravascular Hemoysis, Exacerbated by RBC Transfusion and Associated with Disrupted Arginine-Nitric Oxide Metabolism. Shock. 2022 Nov 16. doi:10.1097/SHK.0000000000002036. Epub ahead of print. PMID: 36378232.
402: Jacob C, Kitagawa A, Signoretti C, Dzieciatkowska M, D'Alessandro A, Gupte A, Hossain S, D'Addario CA, Gupte R, Gupte SA. Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension. J Biol Chem. 2022 Nov 10:102691. doi: 10.1016/j.jbc.2022.102691. Epub ahead of print. PMID: 36372233.
401: Tayachew B, Vanden Brink H, Garcia-Reyes Y, Rahat H, D'Alessandro A, Frank DN, Robertson CE, Silveira L, Kelsey M, Pyle L, Cree-Green M. Combined Oral Contraceptive Treatment Does Not Alter the Gut Microbiome but Affects Amino Acid Metabolism in Sera of Obese Girls With Polycystic Ovary Syndrome. Front Physiol. 2022 Jun 21;13:887077. doi: 10.3389/fphys.2022.887077. PMID: 35800349; PMCID:PMC9255376.
400: Song A, Wen AQ, Wen YE, Dzieciatkowska M, Kellems RE, Juneja HS, D'Alessandro A, Xia Y. p97 dysfunction underlies a loss of quality control of
damaged membrane proteins and promotes oxidative stress and sickling in sickle cell disease. FASEB J. 2022 May;36(5):e22246. doi: 10.1096/fj.202101500RR. PMID:35405035.
399: Bertolone L, Shin HKH, Baek JH, Gao Y, Spitalnik SL, Buehler PW, D'Alessandro A. ZOOMICS: Comparative Metabolomics of Red Blood Cells From Guinea Pigs, Humans, and Non-human Primates During Refrigerated Storage for Up to 42 Days. Front Physiol. 2022 Mar 21;13:845347. doi: 10.3389/fphys.2022.845347. PMID: 35388289; PMCID: PMC8977988.
398: Mandala A, Dobrinskikh E, Janssen RC, Fiehn O, D'Alessandro A, Friedman JE, Jonscher KR. Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. Int J Mol Sci. 2022 May 27;23(11):6043. doi: 10.3390/ijms23116043. PMID: 35682720; PMCID: PMC9181499.
397: Miglio A, Maslanka M, Di Tommaso M, Rocconi F, Nemkov T, Buehler PW, Antognoni MT, Spitalnik SL, D'Alessandro A. ZOOMICS: comparative metabolomics of red blood cells from dogs, cows, horses and donkeys during refrigerated storage for up to 42 days. Blood Transfus. 2022 Jul 25. doi: 10.2450/2022.0118-22. Epub ahead of print. PMID: 35969134.
396: Hadley JB, Kelher MR, D'Alessandro A, Gamboni F, Hansen K, Coleman J, Jones K, Cohen M, Moore EE, Banerjee A, Silliman CC. A pilot study of the metabolic profiles of apheresis platelets modified by donor age and sex and in vitro short-term incubation with sex hormones. Transfusion. 2022 Oct 30. doi:10.1111/trf.17165. Epub ahead of print. PMID: 36309927.
395: Thangaraju K, Katneni U, Akpan IJ, Tanaka K, Thomas T, Setua S, Reisz JA, Cendali F, Gamboni F, Nemkov T, Kahn S, Wei AZ, Valk JE, Hudson KE, Roh DJ, Moriconi C, Zimring JC, D'Alessandro A, Spitalnik SL, Francis RO, Buehler PW. The Impact of Age and BMI on the VWF/ADAMTS13 Axis and Simultaneous Thrombin and Plasmin Generation in Hospitalized COVID-19 Patients. Front Med (Lausanne). 2022 Jan 10;8:817305. doi: 10.3389/fmed.2021.817305. PMID: 35087853; PMCID:PMC8786628
394: Guntur VP, Nemkov T, de Boer E, Mohning MP, Baraghoshi D, Cendali FI, San-Millán I, Petrache I, D'Alessandro A. Signatures of Mitochondrial Dysfunction and Impaired Fatty Acid Metabolism in Plasma of Patients with Post-Acute Sequelae of COVID-19 (PASC). Metabolites. 2022 Oct 26;12(11):1026. doi:10.3390/metabo12111026. PMID: 36355108.
393: Snyder JP, Gullickson SK, Del Rio-Guerra R, Sweezy A, Vagher B, Hogan TC, Lahue KG, Reisz JA, D'Alessandro A, Krementsov DN, Amiel E. Divergent Genetic Regulation of Nitric Oxide Production between C57BL/6J and Wild-Derived PWD/PhJ Mice Controls Postactivation Mitochondrial Metabolism, Cell Survival, and Bacterial Resistance in Dendritic Cells. J Immunol. 2022 Jan 1;208(1):97-109. doi: 10.4049/jimmunol.2100375. Epub 2021 Dec 6. PMID: 34872978; PMCID: PMC8702458.
392: McClary WD, Catala A, Zhang W, Gamboni F, Dzieciatkowska M, Sidhu SS, D'Alessandro A, Catalano CE. A Designer Nanoparticle Platform for Controlled Intracellular Delivery of Bioactive Macromolecules: Inhibition of Ubiquitin-Specific Protease 7 in Breast Cancer Cells. ACS Chem Biol. 2022 Jul
15;17(7):1853-1865. doi: 10.1021/acschembio.2c00256. Epub 2022 Jul 7. PMID: 35796308; PMCID: PMC9295703.
391: Nemkov T, Skinner S, Diaw M, Diop S, Samb A, Connes P, D'Alessandro A. Plasma Levels of Acyl-Carnitines and Carboxylic Acids Correlate With
Cardiovascular and Kidney Function in Subjects With Sickle Cell Trait. Front Physiol. 2022 Jul 13;13:916197. doi: 10.3389/fphys.2022.916197. PMID: 35910560; PMCID: PMC9326174.
390: Vigers T, Vinovskis C, Li LP, Prasad P, Heerspink H, D'Alessandro A, Reisz JA, Piani F, Cherney DZ, van Raalte DH, Nadeau KJ, Pavkov ME, Nelson RG, Pyle L, Bjornstad P. Plasma levels of carboxylic acids are markers of early kidney dysfunction in young people with type 1 diabetes. Pediatr Nephrol. 2022 May 4.doi: 10.1007/s00467-022-05531-3. Epub ahead of print. PMID: 35507146.
389: Anastasiadi AT, Arvaniti VZ, Paronis EC, Kostomitsopoulos NG, Stamoulis K, Papassideri IS, D'Alessandro A, Kriebardis AG, Tzounakas VL, Antonelou MH.Corpuscular Fragility and Metabolic Aspects of Freshly Drawn Beta-Thalassemia Minor RBCs Impact Their Physiology and Performance Post Transfusion: A Triangular Correlation Analysis In Vitro and In Vivo. Biomedicines. 2022 Feb 23;10(3):530. doi: 10.3390/biomedicines10030530. PMID: 35327331; PMCID:PMC8945797.
388: Cralley AL, Moore EE, Fox CJ, Kissau D, DeBot M, Schaid TR, Mitra S, Hom P, Fragoso M, Ghasabyan A, Erickson C, D'Alessandro A, Hansen KC, Cohen MJ, Silliman CC, Sauaia A. Zone 1 REBOA in a combat DCBI swine model does not worsen brain injury. Surgery. 2022 Aug;172(2):751-758. doi: 10.1016/j.surg.2022.04.055. Epub 2022 Jun 9. PMID: 35690490.
387: Schaid TR Jr, Hansen KC, Sauaia A, Moore EE, DeBot M, Cralley AL, Erickson C, Silliman CC, Banerjee A, Ghasabyan A, Jones K, Lacroix I, Mitra S,
D'Alessandro A, Cohen MJ. Postinjury complement C4 activation is associated with adverse outcomes and is potentially influenced by plasma resuscitation. J Trauma Acute Care Surg. 2022 Nov 1;93(5):588-596. doi: 10.1097/TA.0000000000003713.Epub 2022 May 25. PMID: 35610738; PMCID: PMC9613483.
386: Rabcuka J, Blonski S, Meli A, Sowemimo-Coker S, Zaremba D, Stephenson D, Dzieciatkowska M, Nerguizian D, Cardigan R, Korczyk PM, Smethurst PA, D'Alessandro A, Swietach P. Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells. Blood Adv. 2022 Sep 27;6(18):5415-5428. doi: 10.1182/bloodadvances.2022007774. PMID: 35736672; PMCID: PMC9631703.
385: Kim CY, Johnson H, Peltier S, Spitalnik SL, Hod EA, Francis RO, Hudson KE, Stone EF, Gordy DE, Fu X, Zimring JC, Amireault P, Buehler PW, Wilson RB, D'Alessandro A, Shchepinov MS, Thomas T. Deuterated Linoleic Acid Attenuates the RBC Storage Lesion in a Mouse Model of Poor RBC Storage. Front Physiol. 2022 Apr 26;13:868578. doi: 10.3389/fphys.2022.868578. PMID: 35557972; PMCID: PMC9086239.
384: de Bruin S, Peters AL, Wijnberge M, van Baarle FEHP, AbdelRahman AHA, Vermeulen C, Beuger BM, Reisz JA, D'Alessandro A, Vlaar APJ, de Korte D, van Bruggen R. Storage of red blood cells in alkaline PAGGGM improves metabolism but has no effect on recovery after transfusion. Blood Adv. 2022 Jul
12;6(13):3899-3910. doi: 10.1182/bloodadvances.2022006987. PMID: 35477178; PMCID: PMC9278290.
383: Nemkov T, Yoshida T, Nikulina M, D'Alessandro A. High-Throughput Metabolomics Platform for the Rapid Data-Driven Development of Novel Additive
Solutions for Blood Storage. Front Physiol. 2022 Mar 14;13:833242. doi:10.3389/fphys.2022.833242. PMID: 35360223; PMCID: PMC8964052.
382: Stephenson D, Nemkov T, Qadri SM, Sheffield WP, D'Alessandro A. Inductively-Coupled Plasma Mass Spectrometry-Novel Insights From an Old Technology Into Stressed Red Blood Cell Physiology. Front Physiol. 2022 Feb 7;13:828087. doi:10.3389/fphys.2022.828087. PMID: 35197866; PMCID: PMC8859330.
381: Arnold CG, Dylla L, Monte AA, Heard K, Heard S, D'Alessandro A, Reynolds K, Dart R, Rumack B, Sonn B. Metabolomic Evaluation of N-Acetyl-p-Benzoquinone Imine Protein Adduct Formation with Therapeutic Acetaminophen Administration:Sex-based Physiologic Differences. J Med Toxicol. 2022 Oct;18(4):297-310. doi:10.1007/s13181-022-00903-5. Epub 2022 Jun 24. PMID: 35751009; PMCID: PMC9492831.
380: Anastasiadi AT, Tzounakas VL, Dzieciatkowska M, Arvaniti VZ, Papageorgiou EG, Papassideri IS, Stamoulis K, D'Alessandro A, Kriebardis AG, Antonelou MH. Innate Variability in Physiological and Omics Aspects of the Beta Thalassemia Trait-Specific Donor Variation Effects. Front Physiol. 2022 Jun 8;13:907444.doi: 10.3389/fphys.2022.907444. PMID: 35755442; PMCID: PMC9214579.
379: Kalani Roy M, La Carpia F, Cendali F, Fernando S, Moriconi C, Wojczyk BS, Wang L, Nemkov T, Hod EA, D'Alessandro A. Irradiation Causes Alterations of Polyamine, Purine, and Sulfur Metabolism in Red Blood Cells and Multiple Organs. J Proteome Res. 2022 Feb 4;21(2):519-534. doi: 10.1021/acs.jproteome.1c00912. Epub 2022 Jan 19. PMID: 35043621; PMCID: PMC8855667.
378: Nikulina M, Nemkov T, D'Alessandro A, Gaccione P, Yoshida T. A deep 96-well plate RBC storage platform for high-throughput screening of novel storage solutions. Front Physiol. 2022 Oct 4;13:1004936. doi:10.3389/fphys.2022.1004936. PMID: 36277188; PMCID: PMC9583842.
377: Robert M, Laperrousaz B, Piedrahita D, Gautier EF, Nemkov T, Dupuy F, Nader E, Salnot V, Mayeux P, D'Alessandro A, Lavazec C, Joly P, Scheer A, Connes P, Cibiel A. Multiparametric characterization of red blood cell physiology after hypotonic dialysis based drug encapsulation process. Acta Pharm Sin B. 2022 Apr;12(4):2089-2102. doi: 10.1016/j.apsb.2021.10.018. Epub 2021 Oct 26. PMID:35847505; PMCID: PMC9279626.
376: Moriconi C, Dzieciatkowska M, Roy M, D'Alessandro A, Roingeard P, Lee JY, Gibb DR, Tredicine M, McGill MA, Qiu A, La Carpia F, Francis RO, Hod EA, Thomas T, Picard M, Akpan IJ, Luckey CJ, Zimring JC, Spitalnik SL, Hudson KE. Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease. Br J Haematol. 2022 Aug;198(3):574-586. doi: 10.1111/bjh.18287. Epub 2022 Jun 7. PMID: 35670632; PMCID: PMC9329257.
375: Roma A, Tcheng M, Ahmed N, Walker S, Jayanth P, Minden MD, Hope K, Nekkar Rao PP, Luc J, Doxey AC, Reisz JA, Culp-Hill R, D'Alessandro A, Spagnuolo PA. Glutamine Metabolism Mediates Sensitivity to Respiratory Complex II Inhibition in Acute Myeloid Leukemia. Mol Cancer Res. 2022 Nov 3;20(11):1659-1673. doi:10.1158/1541-7786.MCR-21-1032. PMID: 35994381.
374: Hay A, Dziewulska K, Gamboni F, Nerguizian D, Dzieciatkowska M, Zimring JC, D'Alessandro A. Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries. Blood Transfus. 2022 Oct 21. doi:10.2450/2022.0172-22. Epub ahead of print. PMID: 36346885.
373: Nemkov T, Kingsley PD, Dzieciatkowska M, Malik J, McGrath KE, Hansen KC, D'Alessandro A, Palis J. Circulating primitive murine erythroblasts undergo complex proteomic and metabolomic changes during terminal maturation. Blood Adv.2022 May 24;6(10):3072-3089. doi: 10.1182/bloodadvances.2021005975. PMID:35139174; PMCID: PMC9131905.
372: Tzounakas VL, Anastasiadi AT, Stefanoni D, Cendali F, Bertolone L, Gamboni F, Dzieciatkowska M, Rousakis P, Vergaki A, Soulakis V, Tsitsilonis OE,
Stamoulis K, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH. Beta thalassemia minor is a beneficial determinant of red blood cell storage lesion. Haematologica. 2022 Jan 1;107(1):112-125. doi: 10.3324/haematol.2020.273946.
PMID: 33730845; PMCID: PMC8719105. 371: Lee E, Redzic JS, Nemkov T, Saviola AJ, Dzieciatkowska M, Hansen KC, D'Alessandro A, Dinarello C, Eisenmesser EZ. Human and Bacterial Toll-Interleukin Receptor Domains Exhibit Distinct Dynamic Features and Functions. Molecules. 2022 Jul 14;27(14):4494. doi: 10.3390/molecules27144494. PMID:35889366; PMCID: PMC9318647.
370: Donovan K, Meli A, Cendali F, Park KC, Cardigan R, Stanworth S, McKechnie S, D'Alessandro A, Smethurst PA, Swietach P. Stored blood has compromised oxygen unloading kinetics that can be normalized with rejuvenation and predicted from corpuscular side-scatter. Haematologica. 2022 Jan 1;107(1):298-302. doi:10.3324/haematol.2021.279296. PMID: 34498445; PMCID: PMC8719080.
369: Guard SE, Chapnick DA, Poss ZC, Ebmeier CC, Jacobsen J, Nemkov T, Ball KA,Webb KJ, Simpson HL, Coleman S, Bunker E, Ramirez A, Reisz JA, Sievers R, Stowell MHB, D'Alessandro A, Liu X, Old WM. Multiomic Analysis Reveals Disruption of Cholesterol Homeostasis by Cannabidiol in Human Cell Lines. Mol Cell Proteomics. 2022 Oct;21(10):100262. doi: 10.1016/j.mcpro.2022.100262. Epub 2022 Jun 24. PMID: 35753663; PMCID: PMC9525918.
368: Nunns GR, Vigneshwar N, Kelher MR, Stettler GR, Gera L, Reisz JA, D'Alessandro A, Ryon J, Hansen KC, Gamboni F, Moore EE, Peltz ED, Cohen MJ,
Jones KL, Sauaia A, Liang X, Banerjee A, Ghasabyan A, Chandler JG, Rodawig S, Jones C, Eitel A, Hom P, Silliman CC. Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS. Ann Surg. 2022 Dec 1;276(6):e944-e954. doi: 10.1097/SLA.0000000000004644. Epub 2020 Nov 18. PMID: 33214479; PMCID: PMC8128932.
367: Sonn BJ, Heard KJ, Heard SM, D'Alessandro A, Reynolds KM, Dart RC, Rumack BH, Monte AA. Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen. Clin Toxicol (Phila). 2022 Feb;60(2):221-230. doi: 10.1080/15563650.2021.1925686. Epub 2021 May 28. PMID:
34047639; PMCID: PMC8627525.
366: Kalani Roy M, Wilkerson RB, Alexander K, Nokoff NJ, Cree-Green M, D'Alessandro A. Longitudinal metabolic study of red blood cells from patients
undergoing gender-affirming testosterone therapy. Blood Adv. 2022 Aug 24:bloodadvances.2022008061. doi: 10.1182/bloodadvances.2022008061. Epub ahead of print. PMID: 36001490.
365: Ferrero E, Villa A, Stefanoni D, Nemkov T, D'Alessandro A, Tengesdal I, Belloni D, Molteni R, Vergani B, De Luca G, Grassini G, Cangi MG, Dagna L,
Doglioni C, Cavalli G, Ferrarini M. Immunometabolic activation of macrophages leads to cytokine production in the pathogenesis of KRAS-mutated histiocytosis. Rheumatology (Oxford). 2022 Apr 11;61(4):e93-e96. doi:10.1093/rheumatology/keab869. PMID: 34919661.
364: Stotts MJ, Risbano MG, Gorham JD, D'Alessandro A. Red blood transfusion as a potential source for false-positive phosphatidylethanol levels. Transfusion. 2022 Feb;62(2):506-508. doi: 10.1111/trf.16787. PMID: 35146766.
363: Liao Y, Luo Z, Lin Y, Chen H, Chen T, Xu L, Orgurek S, Berry K, Dzieciatkowska M, Reisz JA, D'Alessandro A, Zhou W, Lu QR. PRMT3 drives
glioblastoma progression by enhancing HIF1A and glycolytic metabolism. Cell Death Dis. 2022 Nov 9;13(11):943. doi: 10.1038/s41419-022-05389-1. PMID:36351894; PMCID: PMC9646854.
362: Tzounakas VL, Dzieciatkowska M, Anastasiadi AT, Karadimas DG, Vergaki A, Siourounis P, Stamoulis K, Papassideri IS, Kriebardis AG, D'Alessandro A, Antonelou MH. Red cell proteasome modulation by storage, redox metabolism and transfusion. Blood Transfus. 2022 Jan;20(1):27-39. doi: 10.2450/2020.0179-20. Epub 2020 Nov 27. PMID: 33263521; PMCID: PMC8796840.
361: Catala A, Stone M, Busch MP, D'Alessandro A. Reprogramming of red blood cell metabolism in Zika virus-infected donors. Transfusion. 2022 May;62(5):1045-1064.doi: 10.1111/trf.16851. Epub 2022 Mar 14. PMID: 35285520; PMCID: PMC9086146.
360: Himbert S, D'Alessandro A, Qadri SM, Majcher MJ, Hoare T, Sheffield WP, Nagao M, Nagl JF, Rheinstädter MC. The bending rigidity of the red blood cell cytoplasmic membrane. PLoS One. 2022 Aug 1;17(8):e0269619. doi:10.1371/journal.pone.0269619. PMID: 35913930; PMCID: PMC9342732.
359: Butera A, Roy M, Zampieri C, Mammarella E, Panatta E, Melino G, D'Alessandro A, Amelio I. p53-driven lipidome influences non-cell-autonomous
lysophospholipids in pancreatic cancer. Biol Direct. 2022 Mar 8;17(1):6. doi:10.1186/s13062-022-00319-9. PMID: 35255936; PMCID: PMC8902766.
358: El Kasmi KC, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D'Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic activation of hepatic farnesoid X receptor prevents parenteral nutrition-associated cholestasis in mice. Hepatology. 2022 Feb;75(2):252-265. doi: 10.1002/hep.32101. Epub 2021 Dec 7. PMID: 34387888.
357: Antonelou MH, D'Alessandro A, Kriebardis AG. In Sickness and in Health: Erythrocyte Responses to Stress and Aging. Int J Mol Sci. 2022 Jun
23;23(13):6957. doi: 10.3390/ijms23136957. PMID: 35805962; PMCID: PMC9267024.
356: Patel SB, Nemkov T, D'Alessandro A, Welner RS. Deciphering Metabolic Adaptability of Leukemic Stem Cells. Front Oncol. 2022 Jun 8;12:846149. doi:10.3389/fonc.2022.846149. PMID: 35756656; PMCID: PMC9213881.
355: D'Alessandro A. Editorial: Rising stars in red blood cell physiology: 2022. Front Physiol. 2022 Sep 9;13:1020144. doi: 10.3389/fphys.2022.1020144. PMID:36160846; PMCID: PMC9501848.
354: Galbraith MD, Kinning KT, Sullivan KD, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Guo K, Wilson CC, Santiago ML, Monte AA, Bennett TD, Hansen KC, Hsieh EWY, D'Alessandro A, Espinosa JM. Specialized interferon action in COVID-19. Proc Natl Acad Sci U S A. 2022 Mar 15;119(11):e2116730119. doi:10.1073/pnas.2116730119. PMID: 35217532; PMCID: PMC8931386.
353: Turner JA, Paton EL, Van Gulick R, Stefanoni D, Cendali F, Reisz J, Tobin RP, McCarter M, D'Alessandro A, Torres RM, Robinson WA, Couts KL, Schlaepfer IR. BRAF Modulates Lipid Use and Accumulation. Cancers (Basel). 2022 Apr 23;14(9):2110. doi: 10.3390/cancers14092110. PMID: 35565240; PMCID: PMC9105200.
352: McCubbrey AL, McManus SA, McClendon JD, Thomas SM, Chatwin HB, Reisz JA, D'Alessandro A, Mould KJ, Bratton DL, Henson PM, Janssen WJ. Polyamine import and accumulation causes immunomodulation in macrophages engulfing apoptotic cells. Cell Rep. 2022 Jan 11;38(2):110222. doi: 10.1016/j.celrep.2021.110222.PMID: 35021097; PMCID: PMC8859864.
351: Xu P, Chen C, Zhang Y, Dzieciatkowska M, Brown BC, Zhang W, Xie T, Abdulmalik O, Song A, Tong C, Qi H, Roach R, Kellems RE, D'Alessandro A, Xia Y. Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis. Cell Metab. 2022 Feb 1;34(2):299-316.e6. doi: 10.1016/j.cmet.2021.12.019. PMID: 35108516; PMCID:PMC9380699.
350: Giordano AMS, Luciani M, Gatto F, Abou Alezz M, Beghè C, Della Volpe L, Migliara A, Valsoni S, Genua M, Dzieciatkowska M, Frati G, Tahraoui-Bories J, Giliani SC, Orcesi S, Fazzi E, Ostuni R, D'Alessandro A, Di Micco R, Merelli I, Lombardo A, Reijns MAM, Gromak N, Gritti A, Kajaste-Rudnitski A. DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes. J Exp Med. 2022 Apr 4;219(4):e20211121. doi: 10.1084/jem.20211121. Epub 2022 Mar 9. PMID: 35262626; PMCID: PMC8916121.
349: Traxler L, Herdy JR, Stefanoni D, Eichhorner S, Pelucchi S, Szücs A, Santagostino A, Kim Y, Agarwal RK, Schlachetzki JCM, Glass CK, Lagerwall J,
Galasko D, Gage FH, D'Alessandro A, Mertens J. Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease. Cell Metab. 2022 Sep 6;34(9):1248-1263.e6. doi: 10.1016/j.cmet.2022.07.014. Epub 2022 Aug 19. PMID: 35987203; PMCID: PMC9458870.
348: Amaya ML, Inguva A, Pei S, Jones C, Krug A, Ye H, Minhajuddin M, Winters A, Furtek SL, Gamboni F, Stevens B, D'Alessandro A, Pollyea DA, Reigan P, Jordan CT. The STAT3-MYC axis promotes survival of leukemia stem cells by regulating SLC1A5 and oxidative phosphorylation. Blood. 2022 Jan 27;139(4):584-596. doi:10.1182/blood.2021013201. PMID: 34525179; PMCID: PMC8796651.
2021
·347. van de Wetering C, Manuel AM, Sharafi M, Aboushousha R, Qian X, Erickson C, MacPherson M, Chan G, Adcock I, Kermani NZ, Schleich F, Louis R, Bohrnsen E, D’Alessandro A, Wouters EFM, Reynaert NL, Li J, Anathy V, Wolf R, Henderson C, Bates J, Poynter ME, Dixon AE, Irvin CG, van der Vliet A, van der Velden JL, Janssen-Heininger YMW. Glutathione-S-transferase P promotes glycolysis in asthma via oxidation of pyruvate. Redox Biology 2021; 47:102160. doi: 10.1016/j.redox.2021.102160.
·346. Vigers T, Vinovskis C, Li LP, Prasad P, Heerspink H, D’Alessandro A, Reisz JA, Rosen J, Cherney DZ, van Raalte D, Nadeau KJ, Pavkov ME, Nelson RG, Pyle L, Bjornstad P. Attenuated mitochondrial metabolites associate with markers of early diabetic kidney disease in in young people with type 1 diabetes. 2021; Accepted – waiting for doi
·345. Hay A, Howie H, D’Alessandro A, Spitalnik SL, Hudson KE, Zimring JC. Mouse background genetics in biomedical research: The devil's in the details. Transfusion 2021; 61(10):3017-3025. doi: 10.1111/trf.16628.
·344. Jezewski AJ, Lin YU, Reisz JA, D’Alessandro A, Muller FL, Odom John AR. Targeting Host Glycolysis as a Strategy for Antimalarial Development . Front Cell Infect Microbiol. 2021 Sep 16;11:730413. doi: 10.3389/fcimb.2021.730413.
·343. Patel SB, Nemkov T, D’Alessandro A, Welner RS. Targeting metabolic plasticity of leukemic stem cells. Front Oncol 2021; Accepted – waiting for doi
·342. Roy MK, Cendali F, Gamboni F, Ooyama G, Morton H, D’Alessandro A. Red blood cell metabolism in pyruvate kinase deficient patients. Front Physiol 2021; https://doi.org/10.3389/fphys.2021.735543
·341. Roy MK, Cendali F, Ooyama G, Gamboni F, Morton H, D’Alessandro A. Red blood cell metabolism in patients with propionic acidemia. Int J Mol Sci 2021; https://doi.org/10.3390/separations8090142
·340. D’Alessandro A, Howie HL, Hay A, Lebedev J, Brown BC, Wither MJ, Karafin M, Spitalnik SL, Hod EA, Francis RO, Fu X, Thomas T, Zimring JC. Metabolic Alterations Due to Mediterranean Type I G6PD Deficiency in a Novel Murine Model. JCI Insight 2021; 6(14):e147056. doi: 10.1172/jci.insight.147056.
·339. Bissinger R, Nemkov T, D’Alessandro A, Bohner BN, Essigke D, Worn M, Schaefer L, Xiao M, Kalo Z, Omage K, Kong L, Gonzalez-Mendez I, Quintanilla-Martinez L, Fehrenbacher B, Schaller M, Dietz T, Grau M, Dhariwal A, Jones-Taggart H, Qadri S, Artunc F. Altered lipid repair and redox recycling pathways mediate dysfunction and reduced lifespan of red blood cells in nephrotic syndrome. Kidney International 2021; https://doi.org/10.1016/j.kint.2021.08.024
·338. Traxler L, Lagerwall J, Eichhorner S, Stefanoni D, D’Alessandro A, Mertens J. Metabolism navigates neural cell fate in development aging and neurodegeneration. Disease Models and Mechanisms 2021; doi: 10.1242/dmm.048993
·337. Himbert S, Qadri SM, Sheffield WP, D’Alessandro A, Nagle JF, Rheinstadter MC. Storage of red blood cells leads to an increased membrane order and bending rigidity. PLOS One 2021; Accepted – waiting for doi
·336. D’Alessandro A*, Akpan IJ, Thomas T, Reisz JA, Cendali F, Gamboni F, Nemjov T, Thanagraju K, Katneni U, Tanaka K, Kahn S, Wei AZ, Valk JE, Hudson KE, Roh D, Moriconi C, Zimring JC, Hod EA, Spitalnik SL, Buehler PW, Francis RO. Biological and Clinical Factors contributing to the Metabolic Heterogeneity of Hospitalized Patients with and without COVID-19. Cells 2021; 10(9):2293. doi: 10.3390/cells10092293.*corresponding author
·335. El Kasmi K, Ghosh S, Anderson AL, Devereaux MW, Balasubramaniyan N, D’Alessandro A, Orlicky DJ, Suchy FJ, Shearn CT, Sokol RJ. Pharmacologic activation of FXR Prevents Parenteral Nutrition Associated Cholestasis in Mice. Hepatology 2021; doi: 10.1002/hep.32101.
·334. Tzounakas VL, Anastasiadi AT, Dzieciatkowska M, Karadimas DG, Stamoulis K, Papassideri IS, Hansen KC, D'Alessandro A, Kriebardis AG, Antonelou MH. Proteome of Stored RBC Membrane and Vesicles from Heterozygous Beta Thalassemia Donors. Int J Mol Sci . 2021 Mar 25;22(7):3369. doi: 10.3390/ijms22073369.
·333. Buehler PW, Swindle D, Pak D, Finni M, Hassell K, Nuss R, Wilkerson R, D’Alessandro A, Irwin DC. Murine models of sickle cell disease and beta-thalassemia demonstrate pulmonary hypertension with distinctive features. J Appl Physiol 2021; accepted waiting for doi
·332. Robert M, Laperrousaz B, Piedrahita D, Gautler EF, Nemkov T, Dupuy F, Nader E, Salnot V, Mayeux P, D’Alessandro A, Lavazecc C, Joly P, Scheer A, Connes P, Cibiel A. Multiparametric characterization of red blood cells physiology after hypotonic dialysis-based drug encapsulation process. Acta Pharmacologica Sinica B 2021; accepted waiting for doi
- 331. Ghosh S, Devereaux MW, Anderson AL, Gehrke S, Reisz JA, D'Alessandro A, Orlicky DJ, Lovell M, El Kasmi KC, Shearn CT, Sokol RJ. NF-κB Regulation of LRH-1 and ABCG5/8 Potentiates Phytosterol Role in the Pathogenesis of Parenteral Nutrition-Associated Cholestasis. Hepatology. 2021; doi: 10.1002/hep.32071.
- 330. Kumar S, Frid MG, Zhang H, Li M, Riddle S, Brown RD, D’Alessandro A, Yadav SC, Hansen KC, Stenmark KR. Small Extracellular Vesicles Containing Complement from Pulmonary Hypertensive Adventitial Fibroblasts Induce Metabolic Reprogramming and Pro-Inflammatory Signaling in Macrophages. JCI Insight 2021;
-329. Hunter SK, Hoffman MC, D’Alessandro A, Noonan K, Wyrva A, Freedman R, Law AJ. Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development. Psychol Med. 2021 Feb;51(3):450-459. doi: 10.1017/S0033291719003313.
·328. Sullivan KD, Galbraith MD, Kinning KT, Bartsch K, Levinsky N, Araya P, Smith KP, Granrath RE, Shaw JR, Baxter R, Jordan KR, Russell S, Dzieciatkowska M, Reisz JA, Gamboni F, Cendali F, Ghosh T, Monte A, Bennett TL, Miller MG, Hsieh EWY, D’Alessandro A, Hansen KC, Espinosa JM. The COVIDome Explorer Researcher Portal. Cell Reports 2021; 36(7):109527. doi: 10.1016/j.celrep.2021.109527. – preprint on MedRxiv and PubMed
·327. Clement CC, D’Alessandro A, Thangaswamy S, Mondanelli G, Manni G, Lopez Cara LC, Macchiarulo A, Halin C, Fallarino F, Li TW, Gadina M, Karaman S, Putterman C, Alitalo K, Grohmann U, Santambrogio L. A novel biogenic amine released by lymphatic endothelial cells restrain inflammation. Nature Communications 2021; 12(1):4447. doi: 10.1038/s41467-021-24785-3.
·326. Subedi A, Liu Q, Sharon D, Cathelin S, Xu C, Voisin V, Bader GD, D’Alessandro A, Lechman ER, Dick JE, Minden M, Wang JCY, Chan SM. Nicotinamide Phosphoribosyltransferase Inhibitors Selectively Induce Apoptosis of AML Stem Cells by Disrupting Lipid Homeostasis. Cell Stem Cell 2021; 28(10):1851-1867.e8.
·325. Anderson CC, Merentette JO, Prutton KM, Ahbhishek KR, Reisz JA, D’Alessandro A, Maclean KN, Saba LM, Roede JR. Trisomy 21 results in modest impacts on mitochondrial function and central carbon metabolism. Free Rad Biol Med 2021; ttps://doi.org/10.1016/j.freeradbiomed.2021.06.003
·324. Redzic JS, Born A, Issaian A, Henen MA, Nichols P, Blue A, Hansen KC, D’Alessandro A, Vogeli B, Eisnemesser EZ. The inherent dynamics and interaction sites of the SARS-CoV-2 nucleocapsid N-terminal region. JMB 2021; Accepted – waiting for doi.
·323. Tcheng M, Cunha VLS, Ahmed N, Liu X, Smith WR, Rea KA, Akhtar TA, D’Alessandro A, Minden MD, Vockley J, O’DohertyGA, Lowary TL, Spagnuolo P. Structure-activity relationship of avocadyne. Food and Function 2021; 12(14):6323-6333.
·322. Sonn BJ, Heard KJ, Heard SM, D’Alessandro A, Reynolds KM, Dart RC, Rumack BH, Monte AA. Metabolomic markers predictive of hepatic adaptation to therapeutic dosing of acetaminophen. Clin Toxicol 2021; doi: 10.1080/15563650.2021.1925686.
·321. Patel SB, Nemkov TG, Stefanoni D, Benavides GA, Crown BL, matkins VR, Camacho V, Hoang AT, Tenen DE, Wolock SL, Park J, Ying L, Yue Z, Chen JY, Yang H, Tenen DG, Klein AM, Ferrell PB, Lui R, Darley-Usmar, D’Alessandro A, Bhatia R, Welner RS. STAT3 signaling rewires cellular metabolism of drug insensitive leukemic stem cells. Leukemia 2021; Accepted – waiting for doi
·320. Catala A, Dzieciatkowska M, Wang G, Gutierrez-Hartman, Simberg D, Hansen KC, D’Alessandro A, Catalano CE. Designer Phage Lambda Particles: targeting Her2+ breast cancer. ACS Nano 2021; doi: 10.1038/s41375-021-01315-0.
·319. Cavalli G, De Luca G, Biavasco R, Nemkov T, D’Alessandro A, Arts RJW, Tengesdal I, Villa A, Belloni D, Damascelli A, Grassini G, Cangi G, Doglioni C, Ferrrero E, Ferrarini M, Dagna L. Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease. Blood 2021; doi: 10.1182/blood.2020009594.
·318. Craighead D, Heibockel T, Freeberg K, Rossman MJ, Jackman R, Jankowski L, Hamilton M, Ziemba B, Reisz JA, D’Alessandro A, Brewster LM, DeSouza C, You Z, Chonchol M, Bailey F, Seals D. Time-efficient inspiratory muscle strength training lowers blood pressure and improves endothelial function, nitric oxide bioavailability and oxidative stress in midlife/older adults with above-normal blood pressure. JAHA 2021; 10(13):e020980. doi: 10.1161/JAHA.121.020980.
·317. Morrison EJ, Cendali F, Gamboni F, Fu X, Antonelou MH, Kriebardis A, Welsby I, Busch MP, Kleinman S, Zimring JC, D’Alessandro A. Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. Transfusion 2021; doi: 10.1111/trf.16402.
·316. Esquer H, Zhou Q, Nemkov T, Abraham AD, Rinaldetti S, Chen YC, Orman M, D’Alessandro A, Ferrer M, Messersmith WA, LaBarbera DV. Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer. Oncogene 2021; doi: 10.1038/s41388-021-01728-2.
·314. Tzounakas VL, Anastasiadi AT, Dzieciatkwoska M, Karadimas DG, Stamoulis K, Papassideri IS, Hansen KC, D’Alessandro A, Kriebardis A, Antonelou M. Proteome of Stored RBC Membrane and Vesicles from Heterozygous Beta Thalassemia Donors. Int J Mol Sci. 2021 Mar 25;22(7):3369. doi: 10.3390/ijms22073369.
·313. Sackheim A, Villalba N, Sancho M, Harraz O, Bonev AD, D’Alessandro A, Nemkov T, Nelson MT, Freeman K,. Traumatic Brain Injury Impairs Vascular Function Through Altered Lipid Metabolism and Disruption of Inward-Rectifier Potassium Channels. Function 2021; ;2(3):zqab018. doi: 10.1093/function/zqab018.
·312. Li M, Riddle S, Kumar S, D’Alessandro A, Poczobutt J, Moldovan R, El Kasmi KC, Champagne D, Zhang H, Nemkov T, Fini M, Laux A, McKeon A, Frid MG, Brown D, Hu CJ, Stenmark KR. Microenvironmental Regulation of Macrophage Transcriptomic and Metabolomic Profiles in Pulmonary Hypertension. Front Immunol 2021; 12:640718. doi: 10.3389/fimmu.2021.640718
·311. Morgell A, Reisz JA, Reinsbach S, Del Chiaro M, Sallberg Chen M, D’Alessandro A. Metabolic characterization of plasma and cyst fluid from cystic precursors to pancreatic cancer patients reveal metabolic signatures of bacterial infection. J Prot Res 2021; doi: 10.1021/acs.jproteome.1c00018.
·310. Joshi SK, Nechiporuk T, Bottomly D, Piehowski PD, Reisz JA, Pittsenbarger J, Kaempf A, Gosline SJ, Hanen JR, Gritsenko MA, Hutchinson C, Weitz KK, Wang YT, Moon J, Arshad OA, McDermott JE, Babur O, Watanabe-Smith K, Demir E. D’Alessandro A, Liu T, Tognon CE, Tyner JW, McWeeney SK, Rodland KD, Druker BJ, Traer E. The AML microenvironment catalyzes a step-wise evolution to gilteritinib resistance. Cancer Cell 2021; ;39(7):999-1014.e8. doi: 10.1016/j.ccell.2021.06.003.
·309. Aboushousha R, Elko E, Chia SB, Manuel AM, van de Wetering C, van der Velden J, MacPherson M, Erikson C, Reisz JA, D’Alessandro A, Wouters EFM, Reynaert NL, Lam YW, Anathy V, van der Vliet A, Seward DJ, Janssen-Heininger Y. Glutathionylyation chemistry promotes interleukin 1 beta-mediated metabolic reprogramming and pro-inflammatory signaling in lung epithelial cells. Immunology 2021; 35(5):e21525. doi: 10.1096/fj.202002687RR.
·308. Galbraith M, Kinning KT, Sullivan KD, Baxter R, Araya P, Jordan KR, Smith KP, Granrath RE, Shaw JR, Dzieciatkowska M, Ghosh T, Monte AA, D’Alessandro A, Hansen KC, Bennett TD, Hsieh EWY, Espinosa JM. Seroconversion stages COVID19 into distinct pathophysiological states. eLIFE 2021; doi: ;10:e65508. doi: 10.7554/eLife.65508.
·307. Hunter SK, Hoffman CM, D’Alessandro A, Walker VK, Balser M, Noonan K, Law AJ, Freedman R. Maternal prenatal choline and inflammation effects on 4-year-olds’ performance on the Wechsler Preschool and Primary Scale of Intelligence-IV. J Child Psychology and Psychiatry 2021; accepted – waiting for doi
·306. Zhao H, Serrano K, Stefanoni D, D’Alessandro A, Devine DV. In vitro characterization and metabolomic analysis of cold-stored platelets in plasma. J Prot Res 2021; doi: 10.1021/acs.jproteome.0c00792.
·305. Qiang Q, Manalo JM, Sun H, Chen C, Liu H, Nemkov T, Edwards III G, Zhang Y, Song A, Perreira FA, Kellems RE, Soto C, D’Alessandro A, Xia Y. Erythrocyte adenosine A2B receptor combats age-related cognitive and auditory functional decline by promoting hypoxic and metabolic reprogramming. PLOS Biology 2021; https://doi.org/10.1371/journal.pbio.3001239
·304. Issaian A, Hay A, Dzieciatkowska M, Roberti D, Perrotta S, Darula Z, Redzic J, Hansen KC, Eisenmesser EZ, Zimring JC, D’Alessandro A. The interactome of the N-terminus of band 3 explains its role as a master regulator of red blood cell metabolism and storage quality. Haematologica 2021; doi: 10.3324/haematol.2020.278252.
·303. Freedman B, Hunter SK, D’Alessandro A, Christians U, Ross R. Targeting Treatments to Health Disparities – Letter to the editor. Schizophrenia Buletin 2021; ;47(4):886-887. doi: 10.1093/schbul/sbab051.
·302. Giddins EL, Champagne DP, Laffin JM, Thornton TM, Roberts TS, Fortner Kam Fiering SN, Arias-Pulido H, Romero N, Kam Y, Culp-Hill RC, D’Alessandro A, Rincon M. Energy for ABC transporters to mediate drug efflux in chemoresistant cancer requires mitochondrial respiration. Nature Communications 2021; 12(1):2804. doi: 10.1038/s41467-021-23071-6.
·301. Cavalli G, Gresnitch, D’Alessandro A, Nemkov T, Eisenmesser E, Giugliano M, Dagna C, Netea, Joosten, Dinarello C. The anti-inflammatory cytokine Interleukin 37 is an endogenous regulator of trained immunity. Cell Reports 2021; 35(1):108955. doi: 10.1016/j.celrep.2021.108955.
·300. Tcheng M, Roma A, Ahmed N, Smith RW, Jayanth P, Minden MD, Schimmer AD, Hess D, Hope K, Akhtar TA, Mohsen AW, Bohrnsen E, D’Alessandro A, Vockley J, Spagnuolo P. Very long chain fatty acid metabolism is required in acute myeloid leukemia. Blood 2021; blood.2020008551. doi: 10.1182/blood.2020008551.
·299. D’Alessandro A. In vivo clearance of stored red blood cells: size matters. Editorial. Blood 2021; 137(17):2275-2276. doi: 10.1182/blood.2021010946.
·298. Zhang J, Johnson CB, Olsson A, Slaughter A, May M, Weinhaus B, D’Alessandro A, Engle JD, Jiang JX, Koffron JM, Huang LF, Salomonis N, Grimes HL, Lucas D. Three-dimensional mapping identifies distinct vascular niches for myelopoiesis. Nature 2021; 590(7846):457-462.
·297. Rogers SC, Gia X, Timm DD, d’Arvignon DA, Garbow J, Kao J, Prakash J, Reisz JA, D’Alessandro A, Ackerman J, Doctor A. Energy failure as a novel cause of the red blood cell storage lesion. Transfusion 2021; doi: 10.1111/trf.16395.
·296. Tengesdal IW, Neff CP, Menon DR, Gamboni F, D’Alessandro A, Mauro AG, Stefanoni D, Mills TS, De Graaf D, Azam T, Palmer BE, Pietras EM, DeGregori J, Joosten LAB, Fujita M, Dinarello CA, Marchetti C. The NLRP3 inflammasome facilitates melanoma progression by expansion of myeloid derived suppressor cells. PNAS 2021; 118 (10) e2000915118; https://doi.org/10.1073/pnas.2000915118
·295. Oatman N, Dasgupta N, Arora P, Choi K, Gawali M, Gupta N, Parameswaran S, Salomone J, Reisz JA, Lawler S, Furnari F, Brennan C, Wi J, Sallans L, Gudelsky G, Desai P, Gebelein B, Weirauch MT, D’Alessandro A, Komurov K, Dasgupta B. Mechanisms of Stearoyl Co-A Desaturase inhibitor sensitivity and acquired resistance in cancer. Science Advances 2021; ;7(7):eabd7459. doi: 10.1126/sciadv.abd7459.
·294. Knight WE, Cao Y, Lin YH, Sparagna G, Bai B, Zhao Y, Chi C, Du Y, Londono P, Reisz JA, Brown BC, Taylor MR, Ambardekar AV, McKinseyl TA, Jeong MY, Walker LA, Woulfe KC, D’Alessandro A, Chatfield K, Xu H, Buttrick PM, Song K. Maturation of human induced pluripotent stem cell-derived cardiomyocytes for modeling hypertrophic cardiomyopathy. Stem Cell Reports 2021; 16(3):519-533.
·293. Rossman MJ, Gioscia-Ryan RA, Santos-Parker JR, Ziemba BP, Lubieniecki KL, Johnson LC, Polietkov NE, Bispham NZ, Woodward KA, Nagy EE, Bryan NS, Reisz JA, D’Alessandro A, Chonchol M, Sindler AL, Seals DR. Inorganic nitrite supplementation improves endothelial function with aging: translational evidence for suppression of mitochondria-derived oxidative stress. Hypertension 2021; ;77(4):1212-1222.
·292. Yan D, Franzini A, Pomicter AD, Halverson B, Mason CC, Ahmann JM, Senina AV, Jones C, Zabriskie MS, Than H, Patel AB, Clair PM, Heaton WL, Gantz KC, Reisz JA, D’Alessandro A, Coex JE, Redwine HM, Khorashad JS, O’Hare T, Deininger MW. Acute myeloid leukemia cells are dependent on the lysine deacylase sirt5. Blood Cancer Discovery 2021; DOI: 10.1158/2643-3230.BCD-20-0168
·291. Burchill MA, Finlon JM, Goldberg A, Gillen AE, Dahms P, McMahan RH, Winter A, Reisz JA, Bohrnsen E, D’Alessandro A, Orlicky DJ, Kriss MS, McCullough R, Tamburrini BA. Liver lymphatic function is compromised in a high cholesterol mouse model of non-alcoholic steatohepatitis. 2021; 11(2):573-595.
·290. Tzounakas VL, Anastasiadi A, Stefanoni D, Cendali F, Bertolone L, Dzieciatkowska M, Rousakis P, Vergaki A, Soulakis V, Tsitsilonis OE, Stamoulis K, Papassideri IS, Kriebardis AG, D’Alessandro A, Antonelou M. Beta-thalassemia minor is a beneficial determinant of red blood cell storage lesion. Haematologica 2021; doi: 10.3324/haematol.2020.273946. shared corresponding authorship
·289. Broussard JL, Perreault L, Macias E, Newsom SA, Strauss A, Kerege A, Harrison K, Bui HH, Milligan P, Roth KD, Nemkov T, D’Alessandro A, Brozinick JT, Bergman BC. Sex differences in insulin sensitivity are related to muscle tissue acylcarnitine but not subcellular lipid distribution in people with obesity. Obesity 2021; 29(3):550-561
·288. Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Zinitridou A, Nieves E, Dzieciatkowska M, D’Alessandro A, Will B, Cuervo AM. Chaperone-mediated autophagy sustains hematopoietic stem cell function. Nature 2021; DOI: 10.1038/s41586-020-03129-z
·287 Nemkov T, Skinner SC, Nader E, Stefanoni D, Robert M, Cendali F, Stauffer E, Cibiel A, Boisson C, Connes P, D’Alessandro A. Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling. Int J Mol Sci 2021; 2021 Jan 18;22(2):896. doi: 10.3390/ijms22020896.
·286. Hunter SK, Hoffman C, D’Alessandro A, Wyrwa A, Noonan K, Zeisel SH, Law AJ, Freedman R. Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age. Psychol Med 2021; doi: 10.1017/S0033291720005061.
·285. Dhagia V, Kitagawa A, Jacob C, Zheng C, D’Alessandro A, Edwards JG, Rocic P, Gupte R, Miano JM, Gupte SA. G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases. Am J Physiol Heart Circ Physiol. 2021 Jan 8. doi: 10.1152/ajpheart.00488.2020.
·284. Rice SA, Mikes M, Bibus D, Berdyshev E, Reisz JA, Gehrke S, D’Alessandro A, Drew KL. Omega 3 Fatty Acid Increases Brown Adipose Tissue and Core Body Temperature in the Hibernating Arctic Ground Squirrel. Scientific Reports 2021 11(1):1340. doi: 10.1038/s41598-020-78763-8.
·283. Nemkov T, Stefanoni D, Bordbar A, Issaian A, Palsson BO, Dumont LJ, Hay A, Song A, Xia Y, Redzic JS, Eisenmesser EZ, Zimring JC, Kleinman S, Hansen KC, Busch MP, D’Alessandro A. Blood donor exposome and impact of common drugs on red blood cell metabolism. JCI Insight 2020; DOI: 10.1172/jci.insight.146175
·282. Anderson CC, Marentette JO, Rauniyar AK, Pruton K, Khatri M, Matheson C, Reisz JA, Reigan P, D’Alessandro A, Roede JR. Maneb alters central carbon metabolism and thiol redox status in a toxicant model of Parkinson’s disease. Free Rad Biol Med 2020; 162:65-76. doi: 10.1016/j.freeradbiomed.2020.11.028.
·281. Joshi M, Kim J, D’Alessandro A, Monk E, Bruce K, Elajaili H, Grayck E, Goodspeed A, Costello J, Schlaepfer I. CPT1A Over-expression increases antioxidant defenses via serine metabolism in prostate cancer. Cancers 2020; ;12(11):3431. doi: 10.3390/cancers12113431.281.Thomas T, Stefanoni D, Dzieciatkowska, Issaian A, Nemkov T, Hill RC, Francis RO, Hudson KE, Buehler PW, Zimring JC, Hod EA, Hansen KC, Spitalnik SL, D’Alessandro A. Evidence for structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients. J Proteome Res 2020; ;19(11):4455-4469. doi: 10.1021/acs.jproteome.0c00606.
·280. Culp-Hill R, D’Alessandro A, Pietras EM. Extinguishing the embers: targeting leukemic stem cell metabolism. Trends in Hematol 2020; S1471-4914(20)30262-8. doi: 10.1016/j.molmed.2020.10.00
·279. Bertolone L, Shin HKH, Stefanoni D, Baek JH, Gao Y, Morrison EJ, Nemkov T, Thomas T, Francis RO, Hod EA, Zimring JC, Yoshida T, Karafin M, Schwartz J, Hudson K, Spitalnik SL, Buehler PW, D’Alessandro A. ZOOMICS: Comparative Metabolomics of Red Blood Cells from Old World Monkeys and Humans. Front Physiol: RBC Physiol 2020; ;11:593841. doi: 10.3389/fphys.2020.593841
·278. Clayton ZS,Brunt VE, Htton DA, VanDongen, D’Alessandro A, Culp-Hill R, Reisz JA, Ziemba B, Seals D. Doxorubicin-induced oxidative stress and endothelial dysfunction in conduit arteries is prevented by mitochondrial-specific antioxidant treatment. Am J Card 2020; 2(3):475-488. doi: 10.1016/j.jaccao.2020.06.010.
·277. Rice SA, Have T, Reisz JA, Gehrke S, Stefanoni D, D’Alessandro A, Deutz NEP, Drew KL. Nitrogen recycling buffers against ammonia toxicity from skeletal muscle breakdown in hibernating arctic ground squirrels. Nature Metabolism 2020; ;2(12):1459-1471.
·276. McKinney C, Ellison M, Briones N, Baroffio A, Murphy J, Reisz JA, D’Alessandro A, Ambruso D. Metabolic Abnormalities in G6PC3-Deficient Human Neutrophils Result in Severe Functional Defects. Blood Advances 2020; 4(23):5888-5901.
·275. Ye H, Minhajuddin M, Krug A, Pei S, Culp-Hill R, Ponder J, De Bloois E, Schniedewind B, Amaya M, Inguva A, Stevens BM, Pollyea DA, Christians U, D’Alessandro A, Jordan CT. The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG. Cancer Discovery 2020; doi: 10.1158/2159-8290.CD-20-0318.
·274. Hazegh K, Fang G, Bravo MD, Tran JQ, Muench MO, Jackman RP, Roubinian N, Bertolone L, D’Alessandro A, Dumont LJ, Kanias T. Obesity among blood donors is associated with significant changes in red blood cell metabolism and enhanced susceptibility to hemolysis in cold storage. Transfusion 2020; doi: 10.1111/trf.16168.
·273. Nunns GR, Vigneshwar N, Moore EE, Kelher MR, Gera L, Burke T, Gamboni F, Peltz ED, Stettler GR, Ryon J, D’Alessandro A, Reisz JA, Jones KL, Hansen KC, Sauaia A, Liang X, Banerjee A, Ghasabyan A, Chandler JG, Rodawig S, Jones C, Silliman CC. Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-Mediated ARDS Annals of Surgery 2020; DOI: 10.1097/SLA.0000000000004644
·272. Hunter SK, Hoffman C, McCarty L, D’Alessandro A, Wyrwa A, Noonan K, Christians U, Zeisel SH, Law AJ, Freedman R. African-American Maternal Prenatal Plasma Choline, Gestational Age at Birth, and Developmental Predisposition to Mental Illness. Schizophr Bull. 2020 Nov 13;sbaa171. doi: 10.1093/schbul/sbaa171
·271. D’Alessandro A. Benford’s law and metabolomics: a tale of numbers and blood. Transf Apheresis Sci 2020; 2020 Dec;59(6):103019.
·270. Ding Y, Ball KA, Webb KJ, Gao Y, D’Alessandro A, Old WM, Stowell MHB, Ding X. On-chip Acousto Thermal Shift Assay for Rapid and Sensitive Assessment of Protein Thermodynamic Stability. Small 2020;16(41):e2003506.
·269. D’Alessandro A, Hay A, Dzieciatkowska M, Brown BC, Morrison EJ, Hansen KC, Zimring JC. PIMT1 is required for in vivo control of oxidative damage in red blood cells. Haematologica 2020; DOI: 10.3324/haematol.2020.266676
·268. Tzounakas V, Dzieciatkowska M, Anastasiadi A, Karadimis D, Vergaki D, Siourounis P, Papassideri I, Kriebardis A, D’Alessandro A, Antonelou M. Red blood cell proteasome modulation by storage, redox metabolism and transfusion. Blood Transfusion 2020; doi: 10.2450/2020.0179-20
267. Lonneman N, Hosseini S, Marchetti C, Skouras D, Gamboni F, Stefanoni D, D’Alessandro A, Dinarello CA, Korte M. The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease. PNAS 2020; 117(50):32145-32154.
266. Montgomery TL, Kunstner A, Kennedy JJ, Fang Q, Culp-Hill R, D’Alessandro A, Teuscher C, Busch H, Krementsov DN. Interactions between the host genome and the gut microbiome determine susceptibility to CNS autoimmunity. PNAS 2020; 117(44):27516-27527.
265. Wesolowski SR, Jones AK, Bourque SL Hay WW, D’Alessandro A, Brown LD, Rozance PJ. Effects of chronic hyperinsulinemia on metabolic pathways in the fetal liver. AJP Endocrinology 2020; 319(4):E721-E733.
264. D’Alessandro A, Thomas T, Dzieciatkowska M, Hill RC, Francis RO, Hudson KE, Zimring JC, Hod EA, Spitalnik SL, Hansen KC. Serum proteomics in COVID-19 patients: Altered coagulation and complement status as a function of IL-6 level. J Proteome Res 2020; https://doi.org/10.1021/acs.jproteome.0c00365
263. Mykhailova O, Olafson C, Turner TR, D’Alessandro A, Acker JP. Donor-dependent aging of young and old RBC subpopulations: Metabolic and functional heterogeneity. Transfusion 2020; 0(11):2633-2646.
262. Alexander K, Hazegh K, Fang F, Sinchar D, Kiss JE, Page G, D’Alessandro A*, Kanias Tamir*. Testosterone replacement therapy and erythrocytosis in blood donors modulate erythrocyte metabolism and susceptibility to hemolysis in cold storage. Transfusion 2020; *corresponding authors DOI: 10.1111/trf.16141
261. D’Alessandro A, Stefanoni D, Fu X, Slichter S, Zimring JC. The impact of donor sex and age on stored platelet metabolism and post-transfusion recovery. Blood Transfusion 2020; Accepted – waiting for doi
260. D’Alessandro A, Yoshida T, Nestheide S, Nemkov T, Stocker S, Stefanoni D, Mohmoud F, Rugg N, Dunham A, Cancelas JA. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion 2020; 60(4):786-798.
259. Xie T, Peng Z, Brown B, Chen C, Song A, Zhang Y, Bogdanov M, Zhou Z, Kellems RE, D’Alessandro A, Zhang W, Xia Y. SphK1-S1P controls erythrocyte metabolic homeostasis and function via a PP2A-AMPK cascade in mice and humans with chronic kidney disease. Circulation Research 2020; 127(3):360-375.
258. Freedman R, Hunter SK, Law AJ, D’Alessandro A, Noonan K, Wyrwa A, Hoffman MC. Maternal choline and respiratory coronavirus effects on fetal brain development. J Psychiatr Res. 2020 May 25;128:1-4.
·257. Thomas T, Stefanoni D, Reisz JA, Nemkov T, Bertolone L, Francis RO, Hudson KE, Zimring JC, Hansen KC, Hod EA, Spitalnik SL, D’Alessandro A. COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status. JCI Insight 2020; doi: 10.1172/jci.insight.140327
·256.Catala A, Youssef L, Reisz JA, Dzieciatkowska M, Hansen KC, Spitalnik SL, D’Alessandro A. Metabolic Reprogramming of Bone Marrow Derived Macrophages Upon Erythrophagocytosis. Front Physiol. 2020 Apr 30;11:396. doi: 10.3389/fphys.2020.00396.
·255.Zhou H, Blevins MA, Kong D, Hsu J, Galbraith MD, Goodspeed A, Culp-Hill R, Oliphant MUJ, Ramirez D, Zhang L, Pineiro JT, Gustafson D, Regan D, D’Alessandro A, Costello JC, Patnaik S, Zhao R, Ford HL. Novel small molecule compound disrupts SIX1/EYA2 complex and breast cancer metastasis. Cancer Research 2020; 80(12):2689-2702.
·254.San Millan I, Stefanoni D, Hansen KC, D’Alessandro A, Nemkov T. Metabolomics of Endurance Capacity in World Tour Professional Cyclists. Front Physiol . 2020 Jun 5;11:578. doi: 10.3389/fphys.2020.00578.
·253. Jones CL, Steven BM, Pollyea D, Culp-Hill R, Reisz JA, Nemkov T, Gehrke S, Krug A, Pei S, Gustafson A, Ye H, Abbott D, DeGregori J, Smith C, D’Alessandro A, Jordan CT. Nicotinamide metabolism mediates resistance to venetoclax with azacitidine and targets leukemia stem cells in relapsed/refractory acute myeloid leukemia. Cell Stem Cell 2020; DOI: 10.1016/j.stem.2020.07.021
·252. D’Alessandro A, Fu X, Kanias T, Reisz JA, Culp-Hill R, Guo Y, Gladwin MT, Page G, Kleinman S, Busch M, Zimring J. Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity. Haematologica 2020; doi: 10.3324/haematol.2020.246603.
·251. D’Alessandro A, Fu X, Reisz JA, Kanias T, Page G, Kleinman S, Zimring JC, Busch M. Caffeine levels and stored red blood cell metabolism in the REDS III Omics study. Transfusion. 2020 Jun;60(6):1197-1211.
·250Joshi SR, Kitagawa A, Jacob C, Hashimoto R, Dhagia V, Ramesh A, Zheng C, Zhang H, Jordan A, Waddell, leopold J, Hu CJ, McMurtry IF, D’Alessandro A, Stenmark KR, Gupte SA. Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation. Am J Physiol Lung Cell Mol Physiol 2020; 318(4):L773-L786.
·249. Sayama S, Brown B, Couturier J, Song A, Sibai B, Longo M, Kellems RE, D’Alessandro A, Xia Y. Placental oxygenation and function are controlled by maternal erythrocyte ENT1 to counteract fetal growth restriction. JCI Insight. 2020 May 21;5(10):e130205.
·248. Stevens BM, Jones CL, Pollyea DA, Culp-Hill R, D’Alessandro A, Winters A, Krug A, Abbott D, Goosman M, Pei S, Gillen AE, Savona MR, Smith C, Jordan CT. Fatty acid metabolism mediates venetoclax resistance in acute myeloid leukemia stem cells. Nature Cancer 2019; Accepted – waiting for doi
·247. D’Alessandro A, Fu X, Reisz JA, Kleinman S, Zimring JC, Busch M. Ethyl-glucoronide, a marker of alcohol consumption, correlates with metabolic markers of oxidant stress in stored red blood cells from healthy blood donors. Transfusion. 2020 Jun;60(6):1183-1196.
·246. Dhagia V, D’Alessandro A, Joshi S, Soldatos V, Zheng C, Rocic P, Stenmark KR, Edwards JG, Gupte S. Increased Glucose-6-Phosphate Dehydrogenase regulate metabolome-transcriptome profile and evoke mitochondrial malfunction in diabetic hearts: Implications in pathogenesis of diabetic cardiomyopathy and mending of broken hearts. Hypertension. 2020 Aug;76(2):523-532.
·245. Bertolone L, Kalani Roy M, Hay A, Morrison EJ, Stefanoni D, Fu X, Kanias T, Kleinman S, Dumont LJ, Stone M, Nemkov T, Busch M, Zimring JC, D’Alessandro A. Impact of Taurine on Red Blood Cell Metabolism and implications to blood storage. Transfusion 2020; 60(6):1212-1226.
·244. Stefanoni D, Fu X, Reisz JA, Kanias T, Page G, Dumont LJ, Kleinman S, Busch M, Zimring JC, D’Alessandro A. Smoking increases oxidant stress in stored red blood cells from healthy donor volunteers. Transfusion 2020 Jun;60(6):1160-1174
·243. D’Alessandro A, Xia Y. Erythrocyte metabolic reprogramming under physiological and pathological hypoxia. Curr Opin Haematol 2020; 27(3):155-162
·242. Venkatesh D, O’Brien A, Zandkarimi F, Tong D, Stokes ME, Dunn DE, Kengmana E, Allegra AT, Klein AM, Csuka JM, Moon SH, Chang CJ, Lo C, D’Alessandro A, Prives C, Stockwell B. MDM2 and MDMX facilitate ferroptosis in the absence of p53. Genes & Development 2020; 34(7-8):526-543.
·241. Gillette CM, Hazegh KE, Nemkov T, Stefanoni D, D’Alessandro A, Taliaferro M, Reis T. Gene-diet interactions: dietary rescue of metabolic defects in spen-mutant Drosophila. Genetics 2019; 214(4):961-975.
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240. Francis RO, D’Alessandro A, Eisenberger A, Soffing M, Yeh R, Coronel E, Sheikh A, Rapido F, Reisz JA, Gehrke S, Nemkov T, Thomas T, Schwartz J, Divgi C, Kessler D, Shaz BH, Ginzburg Y, Zimring JC, Spitalnik SL, Hod EA. Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion. Journal of Clinical Investigation (JCI) 2020; DOI: 10.1172/JCI133530
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239. Pei S, Pollyea DA, Gustafson A, Stevens BM, Minhajuddin M, Fu R, Riemondy KA, Gillen AE, Sheridan RM, Kim J, Costello J, Amaya ML, Inguva A, Winters A, Ye H, Krug A, Jones CL, Adane B, Khan N, Ponder J, Schowinsky J, Abbott D, Hammes A, Myers JR, Ashton JM, Nemkov T, D’Alessandro A, Gutman J, Fesik SW, Ramsey HE, Savona MR, Smith CA, Jordan CT. Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Acute Myeloid Leukemia Patients. Cancer Discovery 2020; DOI: 10.1158/2159-8290.CD-19-0710
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238. D’Alessandro A. Personalized Transfusion Medicine. ISBT Focus 2020; Accepted – waiting for doi
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237. Hernandez-Saavedra D, Sanders L, Freeman S, Reisz JA, Lee MH, Mickael C, Kumar R, Kassa B, Gu S, D’Alessandro A, Stenmark KR, Tuder RM, Graham B. Stable isotope metabolomics identifies metabolic changes in pulmonary hypertension. Scientific Reports 2019; DOI: 10.1038/s41598-019-57200-5
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236. Ballak DB, Brunt VE, Sapinsley ZJ, Ziemba B, Richey JJ, Zigler MC, Gioscia-Ryan RA, Culp-Hill R, D’Alessandro A, Dinarello CA, Seals DR. Interleukin-37 treatment improves vascular endothelial function, endurance exercise capacity and glucose-insulin function in old mice. Aging Cell 2020; DOI: 10.1111/acel.13074
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235. Nemkov T, Qadri SM, Sheffield WP, D’Alessandro A. Metabolic effects of different eryptosis-inducing stresses in RBCs. Blood Transfusion 2020; 18(2):130-142.
2020
2019
·234. D’Alessandro A, Thomas KA, Gamboni F, Reisz JA, Spinella PC. Platelet storage temperature and metabolomics. Transfusion 2019; DOI: 10.1111/trf.15651
·233. Janssen WJ, Danhorn T, Harris C, Mould KJ, Lee FFY, Hedin BR, D’Alessandro A, Leach SM, Alper S. Inflammation-induced alternative pre-mRNA splicing in mouse alveolar macrophages. G3 2019; DOI: 10.1534/g3.119.400935
·232. Abraham A, Esquer H, Zhou Q, Tomlinson N, Hamill B, Abbott J, Li L, Pike L, Rinaldetti S, Gomez J, Shaack J, Nemkov T, D’Alessandro A, Hansen K, Messersmith W, LaBarbera D. Drug Design Targeting TCF-Driven Epithelial-Mesenchymal Transition as a Therapeutic Strategy for Colorectal Cancer. J Med Chem 2019; 62 (22), 10182-10203
·231. Hunter S, Hoffman CM, D’Alessandro A, Noonana K, Wyrwaa Am Freedman R, Law AJ. Prenatal Inflammation and Development of Cerebral Inhibition and Infant Behaviors Associated with Later Mental Illness. Psych J 2019; doi: 10.1007/s11920-014-0546-9
·230. Johnson LC, Parker K, Aguirre BF, Nemkov T, D’Alessandro A, Johnson SA, Seals DR, Martens CR. The plasma metabolome as a predictor of biological aging in humans. GeroScience 2019; DOI: 10.1007/s11357-019-00123-w
·229. Stefanoni D, Champagne DP, Nemkov T, Spitalnik SL, Buehler P, D’Alessandro A. Red Blood Cell metabolism in macaques and humans: comparative biology of blood storage. Haematologica 2019; DOI: 10.3324/haematol.2019.229930
·228. Sonn BJ, Saben JL, Shelton S, Flaten HK, D’Alessandro A, Monte A. Clinical and Metabolic markers predicting efficacy of lisinopril therapy. Metabolomics 2019; DOI: 10.1007/s11306-019-1601-7
·227. Powers R, Sullivan K, Culp-Hill R, Ludwig M, Smith KP, Waugh K, Minter R, Tuttle KD, Rachubinski A, Granrath RE, Wilkerson RE, D’Alessandro A, Espinosa J, Costello J. Trisomy 21 disrupts tryptophan catabolism toward production of neurotoxic metabolites via the interferon-inducible kynurenine pathway. Nature Communications 2019;
·226.Chang EI, Wesolowski SR, Gilje EA, Baker PR, Reisz JA, D’Alessandro A, Hay WW, Rozance PJ, Brown LD. Hindlimb (skeletal muscle) amino acid uptake is lower and alanine production greater in late gestation intrauterine growth restricted fetal sheep. Paediatrics 2019; 317 (5), R615-R629
·225.Nohara K, Nemkov T, D’Alessandro A, Yoo SH, Chen Z. Coordinate regulation of cholesterol and bile acid metabolism by the clock modifier Nobiletin in metabolically challenged old mice. Int J Mol Sci 2019; 20(17): 4281.
·224. Moore HB, Culp-Hill R, Reisz JA, Lawson PJ, Sauaia A, Schulick RD, Del Chiaro M, Nydam T, Moore EE, Hansen KC, D’Alessandro A. The metabolic time line of pancreatic cancer: opportunities to improve early detection of adenocarcinoma. Annals of Surgery 2019; 218 (6), 1206-1212
·223. La Carpia F, Wojczyk B, Annavajhala M, Rebbaa A, Shabro A, Culp-Hill R, D’Alessandro A, Freedberg D, Uhlemann AC, Hod EA. Transfusional iron overload and intravenous iron injections modify the mouse gut microbiome similarly to dietary iron. Biomolecules and Biofilms 2019;
·222. Kazunari J, Nemkov T, D’Alessandro A, Zheng C. The clock-enhancing agent Nobiletin promotes healthy aging via optimization of skeletal muscle mitochondrial respiratory complexes. Nature Communications 2019;
·221. Adebyi M, Zhao Z, Ye Y, Manalo J, Hong Y, Lee CC, Xian W, McKeon F, Hill R, D’Alessandro A, Kellems RE, Yoo SH, Han L, Xia Y. The beneficial role of elevated circadian Period 2 in sickle cell disease mice. FASEB J 2019; doi: 10.1096/fj.201900246RR.
·220. Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Campbell RA, Montenont E, Nemkov T, D’Alessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Pietras E, Trahan GD, Jones K, DeGregori J, Rondina MT, Di Paola J. TNF-a driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood 2019; 134 (9), 727-740
·219. D’Alessandro A, Hansen KC, Eisenmesser EZ, Zimring JC. Protect, Repair, Destroy or Sacrifice: could inter-donor variability in the capacity to generate and cope with oxidant stress drive the heterogeneity in progression and severity of the storage lesion across blood donors? Blood Transfusion 2019; 17 (4), 281-288
·218. Gehrke S, Shah N, Gamboni F, Gray A, Landrigan M, Welsby I, D’Alessandro A. Metabolic impact of exchange transfusion with rejuvenated red blood cells in sickle cell patients. Transfusion 2019; 59 (10), 3102-3112
·217. Morrison EJ, Champagne D, Dzieciatkowska M, Nemkov T, Zimring JC, Hansen KC, Guan F, Huffman DM, Santambrogio L, D’Alessandro A. The impact of aging and parabiosis on mouse red blood cell metabolism. Nutrients 2019; doi: 10.3390/nu11061337
·216. D’Alessandro A, Liumbruno GM. Personalized Transfusion Medicine. Blood Transfusion 2019; 17(4): 255–257.
·215.Hoffman CM, Hunter S, D’Alessandro A, Noonan K, Freedman R. Choline Mitigation of Marijuana’s Effects on the Fetal Brain and Child Behavior. Psychological Medicine 2019; DOI: 10.1017/S003329171900179X
214. Williams AT, Jani V, Nemkov T, Lucas A, Yoshida T, Dunham A, D’Alessandro A, Cabrales P. Anaerobically versus conventionally stored blood transfusion after trauma. Shock 2019; DOI: 10.1097/SHK.0000000000001386
213. Howie HL, Hay A, de Wolski K, Waterman H, Fu X, Culp-Hill R, D’Alessandro A, Thomson P, Zimring JC. Genetic Variation of Steap3 Expression is Responsible for Altered Oxidative Damage and Post-Storage RBC Transfusion Biology in a Murine Model. Blood Advances 2019; 3(15):2272-2285.
212. Jones CL, Stevens BM, D’Alessandro A, Culp-Hill R, Reisz JA, Khan N, Agnello G, Rowlinson S, DeGregori J, Pollyea DA, Jordan CT. Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II. Blood 2019; doi: 10.1182/blood.2019898114.
211. Gaikwad H, Wang G, Smith WJ, Alexander KL, D’Alessandro A, Zhang W, Purev E, Simberg D. Clickable Methyltetrazine-Indocarbocyanine Lipids: A Multicolor Tool Kit for Efficient Modifications of Cell Membranes. Bioconjug Chem. 2019; doi: 10.1021/acs.bioconjchem.9b00202.
210. Nechiporuk T, Kurtz SE, Nikolova O, Liu T, Jones CL, D’Alessandro A, Culp-Hill R, d’Alemeida A, Rosenberg M, Tognon C, Danilov AV, Druker BJ, McWeeney SK, Tyner JW. A genome-wide CRISPR screen on AML cells reveals TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition. Cancer Discovery 2019; doi: 10.1158/2159-8290.CD-19-0125.
209. Schmitt L, Henderson R, Barrett A, Darula Z, Issaian A, D’Alessandro A, Chalkley R, Clendenen N, Hansen KC. Molecular Mapping of FXIIIa Cross-links in fibrin clots using cross-linking-Mass Spectrometry. JBC 2019; doi: 10.1074/jbc.AC119.007981.
208.Adane B, Ye H, Khan N, Pei S, Minhajuddin M, Stevens BM, Jones CL, D’Alessandro A, Reisz JA, Zaberezhnyy V, Gasparetto M, Ho TC, Kelly KK, Myers JR, Ashton JM, Siegenthaler J, Kume T, Campbell EL, Pollyea DA, Becker MW, Jordan CT. The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells. Cell Rep. 2019 Apr 2;27(1):238-254.e6.
207. Francis RO, Mahajan S, Rapido F, La Carpia F, Soffing M, Divgi C, Yeh R, Mintz A, Leslie L, Agrest I, Karafin M, Ginzburg Y, Kessler D, Shaz BH, Spitalnik SL, Schwartz J, Fu X, Amireault P, Buffet P, Zimring JC, D’Alessandro A, Hod EA. Re-examination of the chromium-51-labeled post-transfusion red blood cell recovery method. Transfusion 2019; doi: 10.1111/trf.15310.
206. F Freedman R, Hunter SK, Law AJ, Wagner BD, D’Alessandro A, Christians U, Noonan K, Wyrwa A, Hoffman MC. Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development. J Pediatr. 2019;208:198-206.e2.
205. Henriksen HH, McGarrity S, Siguordottir RS, Nemkov T, D’Alessandro A, Stensballe J, Wade CE, Rolfsson O, Johansson PI. Metabolic systems analysis of shock induced endotheliopathy (SHINE) in Trauma – A new paradigm. Annals of Surgery 2019; in press
204. Gehrke S, Rice S, Stefanoni D, Wilkerson R, Nemkov T, Reisz JA, Hansen KC, Lucas A, Cabrales P, Drew K, D’Alessandro A. Red Blood Cell metabolic responses to torpor and arousal in the hibernator arctic ground squirrel. J Prot Res 2019; 18(4):1827-1841.
203. Gregory MA, Nemkov T, Park HJ, Zaberezhnvv V, Gehrke S, Adane B, Jordan CT, Hansen KC, D’Alessandro A, DeGregori J. Targeting glutamine metabolism and redox state for leukemia therapy. Clin Cancer Res. 2019; pii: clincanres.3223.2018. doi: 10.1158/1078-0432.CCR-18-3223.
202. D’Alessandro A, Reisz JA, Zhang Y, Gehrke S, Alexander K, Kanias T, Triulzi D, Donadee C, Barge S, Badlam J, Jain S, Belanger AM, Risbano MG, Gladwin MT. Effects of aged stored autologous red blood cells on human plasma metabolism. Blood Advances 2019; 3(6):884-896.
201. Pham-Danis C, Gehrke S, Danis E, Rohzok A, Daniels M, Gao D, Collins C, Di Paola J, D’Alessandro A, DeGregori J. EGFR inhibition promotes dependency on the urea cycle in EGFR mutant NSCLC. Mol Cancer Res 2018; doi: 10.1158/1541-7786.MCR-18-1068.
200.D’Alessandro A, Zimring JC, Busch M. Chronological storage age and metabolic age of stored red blood cells: are they the same? Transfusion. 2019;59(5):1620-1623.
199. D’Alessandro A. From omics technologies to personalized transfusion medicine. Exp Rev Prot 2019;16(3):215-225.
198. Clendenen N, Clendenen N, Nunns GR, Moore EE, Gonzalez E, Chapman M, Reisz JA, Peltz E, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Silliman CC, Hansen K, Banerjee A, D’Alessandro A, Moore HB. Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements. Blood Transfus. 2018; doi: 10.2450/2018.0188-18.
197. Rogers SC, Dosier LB, McMahon TJ, Zhu H, Timm D, Zhang H, Herbert J, Atallah J, Palmer G, Cook A, Ernst M, Prakesh H, Terng M, Towfighi P, Doctor R, Said A, Joens M, Fitzpatrick J, Hanna G, Lin X, Reisz JA, Nemkov T, D’Alessandro A, Doctor A. Red Blood Cell Phenotype Fidelity following Glycerol Cryopreservation Optimized for Research Purposes. PLoS One. 2018;13(12):e0209201.
196. Moore HB, D’Alessandro A, Moore EE, Wither M, Lawson P, Hansen K, Kam I, Wachs ME, Silliman CC, Banerjee A, Nydam T. Increase in post-reperfusion sensitivity to tissue plasminogen activator-mediated fibrinolysis during liver transplantation is associated with abnormal metabolic changes and increased blood product. Blood Transfus. 2019; doi: 10.2450/2019.0205-18.
195. Hoffman C, Olincy A, D’Alessandro A, Reisz JA, Hansen KC, Hunter SK, Freedman R, Ross RG. Effects of phosphatidylcholine and betaine supplements on women's serum choline. J Nutr Int Metabolism 2019;
194. Yoshida T, Prudent M, D’Alessandro A. Red blood cell storage lesion: causes and potential clinical consequences. Blood Transfus. 2019;17(1):27-52. *corresponding author
193. Lana A*, Alexander K, Castagna A, D’Alessandro A, Morandini F, Pizzolo F, Zorzi F, Mulatero P, Zolla L, Olivieri O. Urinary metabolic signature of primary aldosteronism: gender and subtype specific alterations. Proteomics Clinical Applicaitons 2019; doi: 10.1002/prca.201800049.*shared first authorship
192. Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris IV JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp‐Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, de Stanchina E, Zender L, Tong DR, D’Alessandro A, Lowe SW, Prives C. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell 2019; 176(3):564-580.e19.
191. Fox B, Hyo-Wook G, Griffin B, Jovanovich A, Soranno DE, Gist K, Haines JR, Wither M, D’Alessandro A, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney International 2019; 95(3):590-610.
190. Soderborg TK, Mulligan CE, Clark SE, Babcock L, Janssen RC, Lemas DL, Johnson LK, Frank DN, Weir T, Baarbour LA, Hernandez TL, Kuhn KA, D’Alessandro A, El Kasmi KC, Friedman JE. The Gut Microbiome in Infants of Obese Mothers Increases Hepatic Inflammation and Susceptibility to Obesity and NAFLD in Germ-free Mice. Nature Communications 2019; accepted – waiting for doi
189. Sheridan R, Fong N, D’Alessandro A, Bentley D. Widespread Backtracking by RNA Pol II Is a Major Effector of Gene Activation, 5' Pause Release, Termination, and Transcription Elongation Rate. Molecular Cell; 2019; Mol Cell. 2019 Jan 3;73(1):107-118.e4.
188. Nemkov T, D’Alessandro A, Reisz JA. Metabolic underpinnings of leukemia pathology and treatment. Cancer Reports 2019; invited review
2018
·187. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D’Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 Oct 26;9(1):4462.
·186. Wesolowski SR, Mulligan CM, Janssen RC, Baker PR 2nd, Bergman BC, D’Alessandro A, Nemkov T, Maclean KN, Jiang H, Dean TA, Takahashi DL, Kievit P, McCurdy CE, Aagaard KM, Friedman JE. Switching obese mothers to a healthy diet improves fetal hypoxemia, hepatic metabolites, and lipotoxicity in non-human primates. Mol Metab. 2018 Dec;18:25-41.
·185. Nemkov T, Reisz JA, Xia Y, Zimring JC, D’Alessandro A. Red blood cells as an organ? How deep omics characterization of the most abundant cell in the human body highlights other systemic metabolic functions beyond oxygen transport. Expert Rev Proteomics. 2018 Nov;15(11):855-864.
·184. Reisz JA, Nemkov T, Dzieciatkowska M, Culp-Hill R, Stefanoni D, Hill RC, Yoshida T, Dunham A, Kanias T, Gladwin MT, Kleinman S, Dumont LJ, Busch M, Eisenmesser EZ, Zimring JC, Hansen KC, D’Alessandro A. Methylation of aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Transfusion. 2018 Oct 12. doi: 10.1111/trf.14936.
·183. D’Alessandro A, Culp-Hill R, Reisz JA, Anderson M, Fu X, Nemkov T, Gehrke S, Zheng C, Kanias T, Guo J, Page G, Gladwin M, Kleinman S, Lanteri M, Stone M, Busch M, Zimring JC. Heterogeneity of blood processing and storage additives in different centers impacts stored Red Blood Cell metabolism as much as storage time: lessons from REDS III – Omics. Transfusion 2018; waiting for doi
·182. Jones CL, Stevens BM, D’Alessandro A, Reisz JA, Culp-Hill R, Nemkov T, Pei S, Khan N, Smith C, DeGregori J, Pollyea D, Jordan CT. Venetoclax + Azacytidine Disrupts Amino Acid Metabolism and Targets Leukemia Stem Cells. Nat Med. 2018 Nov 12. doi: 10.1038/s41591-018-0233-1.
·181. Pollyea DA, Stevens BM, Jones CL, Winters A, Pei S, Minhajuddin M, D’Alessandro A, Culp-Hill R, Riemondy KA, Gillen AE, Hesselberth JR, Abbot D, Schatz D, Gutman JA, Purev E, Smith C, Jordan CT. The BCL-2 Inhibitor Venetoclax in Combination with Azacitidine Disrupts Energy Metabolism and Targets Leukemia Stem Cells in Acute Myeloid Leukemia Patients. Cancer Cell. 2018 Nov 12;34(5):724-740.e4. doi: 10.1016/j.ccell.2018.10.005.
·180.Rogers TJ, Green LI, Christenson JL, O’Neill K, Gordon M, Nemkov T, D’Alessandro A, Degala G, Shin J, Tan AC, Labmbert J, Torko K, Richer JK. microrna-200c regulates tryptophan catabolism, pd-l1, and other pathways of immune evasion in breast cancer. Mol Cancer Res. 2018 Sep 13. doi: 10.1158/1541-7786.MCR-18-0246.
·179. Culp-Hill R, Srinivassan J, Gehrke S, Ansari A, Shah N, Welsby I, D’Alessandro A. Effects of red blood cell transfusion on sickle cell disease recipient plasma and erythrocyte metabolism. Transfusion. 2018 Sep 28. doi: 10.1111/trf.14931.
·178. Stevens BM, Khan N, D’Alessandro A, Nemkov T, Winters A, Zhang W, Pollyea DA, Jordan CT. Characterization and Targeting of Emergent Acute Myeloid Leukemia (AML) Stem Cells in Patients with Myelodysplastic Syndromes (MDS). Nat Commun. 2018 Sep 12;9(1):3694
·177. Greene L, Bruno TC, Christenson JL, D’Alessandro A, Culp-Hill R, Torkko K, Borges VF, Slansky JE, Richer JK. : A role for tryptophan 2,3-dioxygenase in CD8 T cell suppression and evidence of tryptophan catabolism in breast cancer patient plasma. Mol Cancer Therapeutics 2018; Accepted – waiting for doi
·176. Klarquist JS, Chitrakar A, Pennock NA, Kilgore AM, Bla in T, Jiang L, Sun J, Hunter CA, D’Alessandro A, Kedl RM. Vaccine-elicited T cell responses utilize IL-27 and IL-15 to support clonal expansion independent of aerobic glycolysis. Science Immunology 2018; Vol. 3, Issue 27, eaas9822; DOI: 10.1126/sciimmunol.aas9822
·175. Karafin M, Fu X, D’Alessandro A, Thomas T, Hod E, Zimring JC, Field J, Francis RO. The Clinical Impact of Glucose-6-Phosphate Dehydrogenase Deficiency in Patients with Sickle Cell Disease. Curr Opin Hematol 2018; Accepted – waiting for doi
·174. Catala A, Culp-Hill R, Nemkov T, D’Alessandro A. Quantitative metabolomics comparison of traditional blood draws and TAP capillary blood collection. Metabolomics 2018;
·173. Paukovich N, Xue M, Elder JR, Redzic JS, Blue AS, Pike H, Miller BG, Pitts T, Pollock DD, Hansen KC, D’Alessandro A, Eisenmesser EZ. Biliverdin reductase B dynamics are coupled to coenzyme binding. J Mol Biol. 2018 Sep 14;430(18 Pt B):3234-3250.
·172. Clendenen N, D’Alessandro A. High Throughput Metabolomics in Clinical Studies: application to remote ischemic preconditioning. Curr Topics In Medicinal Chem 2018;18(25):2143-2153.
·171. Zhang C, D’Alessandro A, Wellendorf A, Whitsett J, Perentesis J, Kumarov K, Stegmaier K, Grimes HL, Cancelas JA. KLF5 tumor suppressor activity of Ph+ B-cell acute lymphoblastic leukemia depends on activation of an anti-oxidant transcriptional program. Oncotarget 2018 ;9(51):29665-29679.
·170. Faulds KJ, Egleston J, Sedivy LJ,Graimella S, Kozlowski H, D’Alessandro A, Hansen KC, Balsbaugh JL, Phiel CJ. A Role For Glycogen Synthase Kinase-3 (Gsk-3) in the Regulation of mRNA Methylation in Mouse Embryonic Stem Cells. Biochemistry 2018; J Biol Chem. 2018 Jul 6;293(27):10731-10743.
·169. Graham B, Kumar R, Mickael C, Kassa B, Koyanagi D, Zhang L, Perez M, Hernandez-Saavedra D, Valencia C, Dixon K, Loomis Z, Nemkov T, Irwin D, D’Alessandro A, Stenmark K, Tuder R. Vascular adaptation of the right ventricle in severe experimental pulmonary hypertension. Am J Respir Cell Mol Biol. 2018; 59(4):479-489.
·168. Zhang Y, Christian BE, Lee JH, Paull TT, Schroeder EA, Gehrke S, D’Alessandro A, Shadel G. Mitochondrial redox signaling by ATM regulates cellular antioxidant capacity. Sci Signal. 2018 Jul 10;11(538).
·167. El Kasmi KC, Vue PM, Anderson AL, Devereaux MW, Ghosh S, Balasubramaniyan N, Fillon SA, Dahrenmoeller C, Allawzi A, Woods C, McKenna S, Wright CJ, Johnson L, D’Alessandro A, Reisz JA, Grayck E, Suchy FJ, Sokol RJ. Macrophage-derived IL-1b/NFkB signaling mediates Parenteral Nutrition Associated Cholestasis. Nature Communications 2018; 9(1):1393. doi: 10.1038/s41467-018-03764-1
·166. D’Alessandro A, Reisz JA, Culp-Hill R, De Korte D, van Bruggen R. The (non-)commutative property of addition to red blood cell storage formulations: effects of alkaline additives and guanosine/gluconate. Transfusion 2018; doi: 10.1111/trf.14620.
·165. Gehrke S, Srivanasan J, Culp-Hill R, Reisz JA, Ansari A, Alan Gray, Matthew Landrigan, Welsby I, D’Alessandro A. Cold bedside rejuvenation as an alternative rejuvenation practice. Transfusion. 2018. doi: 10.1111/trf.14623. *corresponding author
·164. Banerjee A, Silliman CC, Moore EE, Dzieciatskowa M, Kelher M, Sauaia A, Jones K, Chapman MP, Gonzalez E, Moore HB, D’Alessandro A, Peltz E, Huebner BE, Einerson P, Chandler J, Ghasabayan A, Hansen K. Systemic Hyperfibrinolysis after Trauma: A Pilot study of Targeted Proteomic Analysis of Superposed Mechanisms in Patient Plasma. J Trauma Acute Care Surg. 2018 Mar 16. doi: 10.1097/TA.0000000000001878.
·163. Chicco AJ, Le CH, Gnaiger E, Dreyer HC, Muyskens JB, D’Alessandro A, Nemkov T, Hocker AD, Prenni JE, Wolfe LM, Sindt NM, Lovering AT, Subudhi AW, Roach RC. Adaptive remodeling of skeletal muscle energy metabolism in high-altitude hypoxia: Lessons from AltitudeOmics. J Biol Chem. 2018 Mar 14. pii: jbc.RA117.000470.
·162. Reisz JA, Barrett AS, Nemkov T, Hansen KC, D’Alessandro A. When nature's robots go rogue: exploring protein homeostasis dysfunction and the implications for understanding human aging disease pathologies. Expert Rev Proteomics. 2018 Mar 21:1-17. doi: 10.1080/14789450.2018.1453362.
·161. Marchetti C, Swartzwelter B, Gamboni F, Neff CP, Richter K, Azam T, Carta S, Tengesdal I, Nemkov T, D’Alessandro A, Henry C, Jones GS, Goodrich SA, St Laurent JP, Jones TM, Scribner CL, Barrow RB, Altman RD, Skouras DB, Gattorno M, Grau V, Janciauskiene S, Rubartelli A, Joosten LAB, Dinarello CA. OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1530-E1539.
·160. Friedman JE, Dobrinskikh E, Alfonso-Garcia A, Fast A, Janssen RC, Soderborg TK, Anderson AL, Reisz JA, D’Alessandro A, Frank DN, Robertson CE, de la Houssaye BA, Johnson LK, Orlicky DJ, Wang XX, Levi M, Potma EO, El Kasmi KC, Jonscher KR. Pyrroloquinoline quinone prevents developmental programming of microbial dysbiosis and macrophage polarization to attenuate liver fibrosis in offspring of obese mice. Hepatol Commun. 2018;2(3):313-328.
·159. Perreault L, Newsom S, Strauss A, Kerege A, Kahn T, Harrison K, Snell-Bergeon J, Nemkov T, D’Alessandro A, Jackman M, MacLean P, Bergman BC. Intracellular Localization of Diacylglycerols and Sphingolipids influence Insulin Sensitivity and Mitochondrial Function in Human Skeletal Muscle. JCI Insight 2018;3(3). pii: 96805. doi: 10.1172/jci.insight.96805.
·158. Reisz JA, Tzounaka VL, Nemkov T, Voulgaridou AI, Papassideri IS, Kriebardis AG, D’Alessandro A, Antonelou MH. Metabolic linkage and correlations to storage capacity in erythrocytes from glucose 6-phosphate dehydrogenase deficient donors. Frontiers in Medicine 2018 Jan 11;
·157. Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn S, Hess JR, Klein H, Acker J, Spinella P, D’Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon T, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration’s Public Workshop on New Red Blood Cell Product Regulatory Science 2016; Transfusion. 2018. doi: 10.1111/trf.14435.
2017
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156. Culp-Hill R, Zheng C, Reisz JA, Nemkov T, Hansen KC, D’Alessandro A. Red blood cell metabolism in Down Syndrome. Blood Advances 2017; Accepted waiting for doi
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155. Vostal JG, Buehler PW, Gelderman MP, Alayash AI, Doctor A, Zimring JC, Glynn S, Hess JR, Klein H, Acker J, Spinella P, D’Alessandro A, Palsson B, Raife TJ, Busch MP, McMahon T, Intaglietta M, Swartz HM, Dubick MA, Cardin S, Patel RP, Natanson C, Weisel JW, Muszynski JA, Norris PJ, Ness PM. Proceedings of the Food and Drug Administration’s Public Workshop on New Red Blood Cell Product Regulatory Science 2016; Transfusion 2017; Accepted – waiting for doi
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154. Nemkov T, Sun K, Reisz JA, Song A, Yoshida T, Dunham A, Wither MJ, Francis RO, Roach RC, Dzieciatkowska M, Rogers SC, Doctor A, Kriebardis A, Antonelou M, Papassideri I, Hansen KC, Spitalnik SL, Xia Y, Zimring JC, Hod EA, D’Alessandro A*. Hypoxia modulates the purine salvage pathway and decreases cell and supernatant levels of hypoxanthine, a predictor of 24h in vivo survival of stored mouse and human red blood cells. Haematologica 2017; doi: 10.3324/haematol.2017.178608. *corresponding author
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153. Plecita-Hlavata L, D’Alessandro A, El Kasmi K, Zhang H, Jezek P, Stenmark KR. Metabolic reprogramming and redox signaling in pulmonary hypertension. Adv Exp Biol Med 2017; doi: 10.1007/978-3-319-63245-2_14
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152. Nemkov T, Sun K, Reisz JA, Yoshida T, Dunham A, Roach RC, Hansen KC, Xia Y, D’Alessandro A. Metabolism of citrate and other carboxylic acids in erythrocytes as a function of oxygen saturation and refrigerated storage. Frontiers in Medicine 2017; doi: 10.3389/fmed.2017.00175
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151. Reisz JA, Wither MJ, Moore EE, Moore HB, Slaughter AL, Ghasabyan A, Chandler J, Schaub L, Fragoso M, Nunns G, Silliman CC, Hansen KC, Banerjee A, Sheppard FR, D’Alessandro A*. All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhaged rats, pigs, non-human primates and clinical patients. J Trauma 2017; doi: 10.1097/TA.0000000000001721.*corresponding author
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150. Sun K, D’Alessandro A, Zhang Y, Song A, Nemkov T, Reisz J, Wu H, Adebyi M, Liu H, Huang A, Peng Z, Wen YE, Wen QE, Berka V, Bogdanov M, Abdulmalik O, Thai AI, Kellems RE, Dowan W, Hansen KC, Safo M, Xia Y. Structural and functional mechanisms of Sphingosine 1 Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease. Scientific Reports 2017; doi: 10.1038/s41598-017-13667-8.
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149. Barrett AS, Wither MJ, Hill RC, Dzieciatkowska M, D’Alessandro A, Reisz JA, Hansen KC. Hydroxylamine Chemical Digestion for Insoluble Extracellular Matrix Characterization. J Prot Res 2017; 16(11):4177-4184
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148. Gregory M, Nemkov T, Reisz JA, Hansen KC, D’Alessandro A, Degregori J. Glutaminase inhibition improves FLT3 inhibitor therapy for acute myeloid leukemia. Exp Hematol 2017; doi: 10.1016/j.exphem.2017.09.007
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147. Zhang H, Riddle S, Li M, D’Alessandro A, El Kasmi K, Stenmark K. The role of CTBP1/miR-124/PKM2 signaling axis in metabolic reprogramming of pulmonary hypertension. Circulation 2017; doi: 10.1161/CIRCULATIONAHA.117.028069
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146. Caruso P, Dunmore BJ, Schlosser K, Schoors S, Dos Santos C, Perez-Iratxeta C, Lavoie JR, Zhang H, Long L, Flockton A, Frid MG, Kiskin FN, Hurst L, Ormiston ML, Hata A, D’Alessandro A, Stenmark KR, Carmeliet P, Stewart DJ, Morrell NW. Identification of miR-124 as a major regulator of enhanced endothelial cell glycolysis in pulmonary arterial hypertension by miRNA and proteomic profiling. Circulation 2017; doi: 10.1161/CIRCULATIONAHA.117.028034
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145. Culp-Hill R, Reisz JA, Hansen KC, D’Alessandro A. Investigation of the effects of storage and freezing on mixes of heavy-labeled metabolite and amino acid standards. Rapid Comm Mass Spectrometry 2017; 31(23):2030-2034.
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144. Henry CJ, Nemkov T. Casas-Selves M, Bilousova G, Zaberezhnyy V, Higa K, Serkova NJ, Hansen KC, D’Alessandro A, DeGregori J. Deficient and Excessive Dietary Folate Levels Similarly Impact Metabolism and Compromise Hematopoiesis. Haematologica 2017; doi: 10.3324/haematol.2017.171074.
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143. Thwe P, Beauchamp S, Reisz J, D’Alessandro A, Amiel E. Cell-intrinsic glycogen metabolism supports early glycolytic reprogramming associated with dendritic cell immune effector function. Cell Metabolism 2017; 26(3):558-567.e5.
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142. Slaughter A*, Nunns G, D’Alessandro A, Banerjee A, , Hansen KC, Moore EE, Silliman CC, Nemkov T, Moore HB, Fragoso M, Wither M, Leasia K, Peltz ED. The Metabolopathy of Tissue Injury, Hemorrhagic Shock and Resuscitation in a Rat Model. Shock 2017; doi: 10.1097/SHK.0000000000000948
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141. Hazegh KE, Nemkov T, D’Alessandro A, Monks J, Bales E, McManaman J, Hansen KC, Reis T. An autonomous metabolic role for Split Ends. PLOS Genetics 2017; 13(6):e1006859.
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140. Sun K, Liu H, Song A, Manalo JM, D’Alessandro A, Hansen KC, Kellems RE, Eltzschig HK, Blackburn MR, Roach RC, Xia Y. Erythrocyte Purinergic Signaling Components Underlies Hypoxia Adaptation. J Appl Physiol 2017; 123(4):951-956.
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139. D’Alessandro A, Moore HB, Reisz J, Hansen KC, Silliman C, Banerjee A, Moore EE. Plasma succinate is a predictor of mortality in critically injured patients. J Trauma 2017; 83(3):491-495. * corresponding author
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138. Clendenen N, Nunns GR, Moore EE, Reisz JA, Gonzalez E, Peltz E, Silliman CC, Fragoso M, Nemkov T, Wither MJ, Sauaia A, Hansen KC, Banerjee A, Moore HB, D’Alessandro A*. Hemorrhagic Shock, not Poly-Trauma, Drives the Plasma Metabolome Derangement in Pigs. J Trauma 2017; 83(4):635-642
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137. D’Alessandro A, Grayk E, Stenmark KR. Identification of Infants at Risk for Chronic Lung Disease at Birth: Potential for a Personalized Approach to Disease Prevention. Am J Crit Resp Care Med Blue 2017; 196(8):951-952.
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136. Reisz JA, Slaughter A, Culp-Hill R, Moore EE, Silliman CC, Fragoso M, Peltz ED, Hansen KC, Banerjee A, D’Alessandro A*. Red Blood Cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination reactions in rats. Blood Advances 2017; 1:1296-1305. *corresponding author
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135. Gehrke S, Reisz JA, Nemkov T, Hansen KC, D’Alessandro A*. Characterization of rapid extraction protocols for high-throughput metabolomics. Rapid Comm Mass Spectrometry 2017; 31(17):1445-1452. *corresponding author
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134. Reisz JA, D’Alessandro A*. Measurements of metabolic fluxes using stable isotope tracers in whole animals and human patients. Curr Opinion in Clin Nutr Metabolic Care 2017; 20(5):366-374. *corresponding author
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133. Mould KJ, Barthel L, Mohning MP, Thomas SM, McCubbrey A, Danhorn T, Leach S, Fingerlin T, O’Connor B, Reisz J, D’Alessandro A, Bratton D, Jakubzick C, Henson P, Janssen WJ. Resident And Recruited Alveolar Macrophages Exhibit Distinct Immunometabolic Programs In The Inflamed Alveolus. Am J Resp Cell Mol Biol 2017; 57(3):294-306.
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132. D’Alessandro A, Plecita-Hlavata L, El Kasmi K, Li M, Zhang H, Jezek P, Stenmark KR. Hallmarks of pulmonary hypertension. Antioxidant Redox Signaling 2017; doi: 10.1089/ars.2017.7217.
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131. Sun K, D’Alessandro A, Xia Y. Red blood cell storage and purinergic signaling. Blood Transfuion 2017; 15(6):535-542.
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130. Nemkov T, Hansen KC, D’Alessandro A* Three Minute Method for high-throughput quantitative metabolomics and quantitative flux-analysis of central carbon and nitrogen pathways. Rapid Comm Mass Spectrometry 2017; 31(8):663-673. *corresponding author
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129. D’Alessandro A, Liumbruno GM. Editorial. Red blood cell storage and clinical trials. Blood Transfusion 2017; 15(2):101-103.
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128. D’Alessandro A, Seghatchian J. Hitchhiker’s guide to the red blood cell storage galaxy. Transfusion Science 2017; 56(2):248-253.
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127. D’Alessandro A, Zolla L. Red blood cell proteomics for clinical applications. Exp Rev Prot 2017; 14(3):243-252. *corresponding author
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126. Clendenen N, Toellfson A, Dzieciatkowska M, Cambiaghi A, Ferrario M, Kroehl M, Banerjee A, D’Alessandro A, Hansen KC, Weitzel N. Discovery phase of coagulation profile testing in cardiac surgery using QconCAT proteomics technology. Proteomics Clin Appl 2017; 11(7-8).
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125. Cavalli G, Justice JN, Boyle KE, D’Alessandro A, Herrera JJ, Hansen KC, Nemkov T, Stienstra R, Dagna L, Joosten LAB, Seals DR, Ballak DB, Dinarello C. Treatment with recombinant IL-37 ameliorates inflammation induced-fatigue and improves exercise tolerance: Dual mode of action via modulation of anti-inflammatory and metabolic pathways. PNAS 2017; 114(9):2313-2318.
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124. Yoshida T, Blair A, D’Alessandro A, Dioguardi M, Silliman CC, Dunham A. Enhancing uniformity and overall quality of RCC with anaerobic storage. Blood Transfusion 2017; 15(2):172-181.
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123. D’Alessandro A, Nemkov T, Reisz J, Dzieciatkowska M, Wither MJ, Hansen KC. Omics markers of the red cell storage lesion and metabolic linkage. Blood Transfusion 2017; 15(2):137-144.
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122. D’Alessandro A, Szczepiorkowski Z, Gray AD, Dumont LJ. Metabolomics of outdated red blood cells upon rejuvenation-freezing/thawing/deglycerolization and 4C overnight hold after 24h refrigerated storage. Transfusion 2017; 57(4):1019-1030.
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121. Pei S, Minhajuddin M, D’Alessandro A, Nemkov TG, Stevens BM, Adane B, Khan N, Hagen FK, Yadav VK, De S, Ashton JM, Hansen KC, Gutman JA, Pollyea DA, Crooks PA, Jordan CT. Rational design of therapeutic regimens that selectively target acute myelogenous leukemia stem cells. J Biol Chem 2017; 291(48):25280.
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120. D’Alessandro A, Nemkov T, Martin S, Hansen KC. Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.. J Prot Res 2017 16(2):958-969. *corresponding author
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119. Kendrick A, Shaffer J, Dzieciatkowska M, Nemkov T, D’Alessandro A, Neelakantan D, Pearson CG, Weekes CD, Hansen KC, Eisenmesser EZ. CD147 reprograms pancreatic cancer metabolism via its interaction with multiple small molecule transporters. Oncotarget 2017; 8(4):6742-6762.
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118. Goddard E, Hill RC, Nemkov T, D’Alessandro A, Hansen KC, Maller O, Borges V, Schedin P. Weaning induced liver involution and the metastatic niche. Cancer Discovery 2017; 7(2):177-187.
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117. Song A, Zhang Y, Han L, Yegutkin GG, Liu H, Sun K, D’Alessandro A, Lee J, Karmouty-Quintana H, Iriyama T, Weng T, Zhao S, Wang W, Wu H, Hansen KC, Zhang H, Bogdanov M, Dowhan W, Jin J, Kellems RE, Eltzschig HK, Blackburn M, Roach RC0, Xia Y. Erythrocytes retain “hypoxic purinergic memory” for faster acclimatization upon re-ascent. Nat Comm 2017; 8:14108.
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116. Reisz JA, Chessler KM, Dzieciatkowska M, D’Alessandro A*, Hansen KC. Blood and plasma proteomics: targeted quantitation and post-translational redox modifications. Meth Mol Biol 2017; 1619:353-371. *corresponding author
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115. D’Alessandro A, Dzieciatkowska M, Nemkov T, Hansen KC. A Red blood cell proteomics update- is there more to discover? Blood Transfusion 2017; 15(2):182-187.
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114. D’Alessandro A*, Nemkov T, Yoshida T, Bordbar A, Palsson BO, Hansen KC, Quantitative metabolic flux analysis of red blood cells stored in Additive Solution-3 reveals unappreciated metabolism of other substrates than glucose. Transfusion 2017; ;57(2):325-336. *corresponding author
2016
· 113. D’Alessandro A*, Nemkov T, Sun K, Xia Y, Monte AA, Subudhi AW, Julian CG, Lovering AT, Dvorkin D, Kevil CG, Gladwin MT, Hansen KC, Roach RC. AltitudeOmics: Red Blood Cell metabolic adaptation to high altitude hypoxia. J Prot Res 2016; ;15(10):3883-3895* corresponding author
· 112. D’Alessandro A* Red blood cell storage lesion. Vox Sang ISBT Series 2016; DOI: 10.1111/voxs.12298 *corresponding author
·111. Liu C, D’Alessandro A, Xia Y. Metabolomics approach in probing drug candidates. Curr Topics Med Res 2016; invited review DOI : 10.2174/1568026617666161116144146
·110. Gregory M, D’Alessandro A, Alvarez-Calderon F, Kim J, Nemkov T, Rohzok A, Kumar A, Kumar V, Wempe MF, Serkova N, Tan AC, Hansen KC, DeGregori J. ATM/G6PD-dependent metabolic pathways promote mitochondrial redox homeostasis and resistance to FLT3 inhibition in acute myeloid leukemia. PNAS 2016; 113(43):E6669-E6678.
·109. Paglia G, D’Alessandro A, Sigurjonsson O, Rolfsson O, Bordbar A, Gudmondsson S, Nemkov T, Hansen KC, BO. Biomarkers defining the metabolic age of red blood cells during cold storage. Blood 2016; 128(13):e43-50.
·108. Gamboni F, Anderson C, Sanchayita M, Nemkov T, Dzieciatkowska M, Jones KL, Hansen KC, D’Alessandro A, Banerjee A. Hypertonic saline primes activation of the p53/p21 signaling axis in Small Airways Epithelial Cells that prevents inflammation induced by pro-inflammatory cytokines. J Prot Res 2016; 15(10):3813-3826.*corresponding author
·107. Slaughter A, D’Alessandro A, Banerjee A, Silliman CC, Hansen KC, Haines J, Peltz ED, Fragoso M, Wither M, Bacon A, Moore HB, Moore EE. Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock. J Trauma 2016; 81(6):1012-1019.
·106. Li M, Riddle S, Zhang H, D’Alessandro A, Flockton A, Serkova N, Hansen KC, Moldvan R, Poth J, McKeon AB, Frid M, Li H, Liu H, Canovas A, Medrano J, Illoska D, Plecita-Hlavata L, Jezek P, Fini M, Pullamsetti S, El Kasmi KC, Zhang Q, Stenmark K. Glycolytic reprogramming regulates the proliferative and inflammatory phenotype of adventitial fibroblasts in pulmonary hypertension through the transcriptional co-repressor C-terminal Binding Protein-1. Circulation 2016; 134(15):1105-1121
·105. Reisz JA, Wither M, Dzieciatkowska M, Issaian A, Hansen KC, D’Alessandro A*. Metabolic regulation through oxidation/ vesiculation of glyceraldehyde 3-phosphate dehydrogenase in red blood cells stored under blood bank conditions in additive solution 3. Blood 2016; 128(12):e32-42. *corresponding author
·104. Tzounakas VL, Kriebardis AG, Georgatzakou H, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri I, D’Alessandro A,# and Marianna H. Antonelou#. Data on how several physiological parameters of stored red blood cells are similar in glucose 6-phosphate dehydrogenase deficient and sufficient donors. Free Rad Biol Med 2016; ;8:618-27. d *corresponding author
·103. Liu H, Zhang Y, Song A, Yegutkin GG, D’Alessandro A, Lee J, Cheng NY, Sun H, Kellems RE, Karmouty-Quintana H, Wen TT, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Eltzschig HK, Blackburn MK, Nemkov T, Hansen KC, Roach RC, Xia Y. Adenosine signaling via AMPK-induced erythrocyte oxygen release: a key mechanism for human hypoxia adaptation and novel therapy.Circulation 2016; ;134(5):405-21.
· 102. Sun K*, Zhang Y*, D’Alessandro A*, Song A, Wu H, Liu H, Adebiyi M, Huang A, Wen YE, Bogdanov MV, Nemkov T, Hansen KC, Kellems RE, Dowhan W, Subudhi AW, Jameson-Van Houten S, Julian CG, Lovering AT, Vila A, O’Brien J, Roach RC, Yang X. Erythrocyte sphingosine 1 phosphate: a key intracellular modulator for adaptation to high altitude hypoxia. Nature Comm 2016; 7:12086. *shared first authorship
· 101. Tzounakas VL, Kriebardis AG, Georgatzakou H, Foudoulaki-Paparizos LE, Dzieciatkowska M, Wither MJ, Nemkov T, Hansen KC, Papassideri I, D’Alessandro A,# Antonelou MH#. Storage of glucose 6-phosphate dehydrogenase deficient red blood cells . Free Rad Biol Med 2016; 96:152-65.. #corresponding authors
· 100. Newsom SA, Brozinick JT, Strauss AN, Bacon SD, Kerege AA, Hoang Bui H, Sanders P, Siddall P, Wei T, Thomas M, Shang Kuo M, Nemkov TG, D’Alessandro A, Hansen KC, Perreault L, Bergman BC. Skeletal muscle phosphatidylcholine and phosphatidylethanolamine are related to insulin sensitivity and responsive to acute exercise in humans. J Appl Physiol 2016; 120(11):1355-63
· 99. Goodman SR, Pace BS, Hansen KC, D’Alessandro A, Xia Y, Daescu O, Glatt S. Multiomic candidate biomarkers for clinical manifestations of sickle cell severity: early steps to precision medicine. Exp Biol Med 2016; 241(7):772-81.
· 98. Champagne DP, Hatle KM, Fortner KA, D’Alessandro A, Thornton TM, Yang R, Torralba D, Tomas-Cortazar J, Woong Jun Y, Han Ahn K, Hansen KC, Haynes L, Anguita J, Rincon M. Fine-tuning of CD8 T cell mitochondrial respiration by MCJ/DnaJC15 dictates protection to influenza virus. Immunity 2016; 44(6):1299-311.
· 97. D’Alessandro A*#, Moore HB*, Moore EE, Wither MJ, Nemkov T, Morton AP, Gonzalez E, Chapman MP, Fragoso M, Slaughter A, Sauaia A, Silliman CC, Hansen KC, Banerjee A. Plasma first resuscitation buffers metabolic derangement from profound shock. Shock 2016; 46(2):173-82. * shared first authorship #corresponding author
· 96. D’Alessandro A, Dzieciatkowska M. Hill R, Hansen KC. Supernatant protein biomarkers of red blood cell storage hemolysis as determined through an absolute quantification proteomics technology. Transfusion 2016; 56(6):1329-39.
· 95. Plecitá-Hlavatá L, TauberJ, Li M, Zhang H, Flockton AR, Pullamsetti SS, Chelladurai P, D’Alessandro A, El Kasmi KC, Ježek P, Stenmark KR. Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension. American Journal of Respiratory Cell and Molecular Biology 2016; 55(1):47-57.
· 94. D’Alessandro A, Nemkov T, Moore HB, Moore EE, Wither M, Nydam T, Slaughter A, Silliman C, Banerjee A, Hansen KC. Metabolomics of trauma-associated death: shared and fluid-specific features of human plasma versus lymph. Blood Transfusion 2016; 14(2):185-94. * corresponding author
· 93. Nemkov T, Hansen KC, Ness P, Dumont LJ, D’Alessandro A*. Metabolomics in Transfusion Medicine. Transfusion 2016; 56(4):980-93. * corresponding author
· 92. D’Alessandro A. Leucoreduction of blood components: clinical and molecular evidence. Invited Commentary; Blood Transfusion 2016; ;14(2):212-3.
· 91. D’Alessandro A*,#, Nemkov T*, Hansen KC. Rapid detection of phthalate plasticizers in SAGM and AS-3 red blood cells. Blood Transfusion 2016; 14(2):140-4. *shared first authorship #corresponding author
· 90. Wither M, Dzieciatkowska M, Nemkov T, Strop P, D’Alessandro A*, Hansen KC. Hemoglobin oxidation at functional amino acid residues during routine storage of SAGM red blood cells. Transfusion 2016; 56(2):421-6. * corresponding author
· 89. Dumont LJ, D’Alessandro A, Szczepiorkowski Z, Yoshida T. CO2-dependent metabolic modulation in red blood cells stored under anaerobic conditions Transfusion 2016; 56(2):392-403.
· 88. D’Amato N, Rogers T, Gordon M, Green L, Chocrane D, Spolestra N, Nemkov T, D’Alessandro A, Hansen KC, Richer J. A TDO2-AhR Signaling Axis Is Upregulated in Suspension and Regulates Metastatic Phenotypes in Triple-Negative Breast Cancer. Cancer Res 2015; 75(21):4651-64.
· 87. Moore HB, Moore EE, Chapman MP, Gonzalez E, Slaughter AL, Morton AP, D’Alessandro A, Hansen KC, Sauaia A, Silliman CC, Banerjee A. Viscoelastic measurements of platelet function not fibrinogen function predicts sensitivity to tissue plasminogen activator in trauma patients. J Thrombosis Hemostasis 2015; 13(10):1878-87.
· 86. D’Alessandro A*, Slaughter A*, Wither M, Nemkov T, Fragoso M, Pelttz ED, Hansen KC, Banerjee A. Hemorrhagic shock exacerbates plasma metabolic derangement primed by trauma: a preliminary 13C-glucose labeling experiment on a well-established rat model of trauma/hemorrhagic shock. J Translational Medicine 2015, 5;13:253. *shared first authorship
· 85. Mosher J, Zhang W, Blumhagen RZ, D’Alessandro A, Nemkov T, Hansen KC, Hesselberth JR, Reis T. Coordination between Drosophila Arc1 and a specific population of brain neurons regulates organismal fat. Developmental Biology 2015; 405(2):280-90.
· 84. D’Alessandro A, Nemkov T, Hansen KC, Szczepiorkowski ZM, Dumont LJ. Red Blood Cell storage in Additive Solution-7 preserves energy and redox metabolism: a metabolomics approach. Transfusion 2015; 55(12):2955-66.
· 83. Nemkov T*, D’Alessandro A*, Hansen KC. A3: Three minute method for amino acid analysis. Amino Acids 2015; 47(11):2345-57. *shared first authorship
· 82. Hill R, Wither M, Dzieciatkowska M, Nemkov T, Barrett A, D’Alessandro A, Hansen K. Preserved protein from extinct Bison latifrons identified by Tandem Mass Spectrometry. Mol Cell Prot 2015; 14(7):1946-58
· 81. D’Alessandro A*, Moore HB, Wither M, Nemkov T, Gonzalez E, Fragoso M, Banerjee A, Hansen KC, Silliman CC, Moore EE. Early hemorrhage triggers metabolic responses that build up during prolonged shock. Am J Physiol Reg Integr Comp Physiol 2015; ;308(12):R1034-44. *corresponding author
· 80. Hansen KC, D’Alessandro A, Clement CC, Santambrogio L. Lymph formation composition and circulation: a proteomics perspective.International Immunol 2015; 27(5):219-227.
· 79. Dzieciatkowska M, D’Alessandro A, Hill RC, Hansen KC. Plasma QConCATs reveal a gender-specific proteomic signature in apheresis platelet plasma supernatants. J Proteomics 2015; 120:1-6.
· 78. Taamalli M,* D’Alessandro A*, Marrocco C, , Abdelly C, Zolla L. Cadmium stress responses in the halophyte Cakile maritimaMolecular BIosystems 2015; 11(4):1096-109. * shared first authorship
· 77. Wiener G, Moore HB, Moore EE, Gonzalez E, Diamond S, Zhu S, D’Alessandro A, Banerjee A. Shock Releases Bile Acid Attributable to Platelet Inhibition and Fibrinolysis. J Surgical Res 2015; 195(2):390-5.
· 76. Peltz E*, D’Alessandro A*, Moore E, Chin T, Silliman C, Sauaia A, Hansen KC, Banerjee A. Pathologic Metabolism: The Plasma Metabolome of Critical Injury. J Trauma Acute Care Surgery 2015; 78(4):742-51. *shared first authorship
· 75. Zolla L, D’Alessandro A, D’Amici GM, Rinalducci S, Pupella S, Grazzini G, Vaglio S. Classic and alternative Red blood cell storage strategies: Seven years of Omics investigations. Blood Transfusion 2015; 13: 21-31.
· 74. D’Alessandro A*,#, Nemkov T, Kelher M, West B, Schwindt R, Moore EE, Banerjee A, Silliman CC, Hansen KC. Routine Storage of Red Blood Cell Units in Additive Solution-3: a comprehensive investigation of the RBC metabolome Transfusion 2015; 55(6):1155-68. * corresponding author
· 73. D’Alessandro A,#, Kriebardis A, Rinalducci S, Antonelou M, Hansen KC, Papassideri I, Zolla L. An update on red blood cell storage lesions, as gleaned through biochemistry and omics technologies. Transfusion 2015; 55(1):205-19.
· 72. D’Alessandro A, Hansen KC, Silliman C, Moore EE, Kelher M, Banerjee A. Metabolomics of AS-5 RBC supernatants Vox Sanguinis 2015; 108(2):131-40
· 71. Lana A, Longo V, Dalmasso A, D’Alessandro A, Bottero MT, Zolla L. Extended hanging period promotes Piedmontese beef tenderness without compromising meat safety. Food chemistry 2015; 172(731):741.
· 70.Dzieciatkowska M,* D’Alessandro A*, Moore EE, Banerjee A, Hansen K, Silliman CC. Proteomics of apheresis platelet supernatants during storage in the blood bank: gender-related differences. J Proteomics 2015; 112C:190-209. *shared first authorship
2015
· 69. Cilli D, Mirasole C, Pennisi R, Pallotta V, D’Alessandro A, Antoccia A, Zolla L, Ascenzi P, Di Masi A. Proteomic identification of the interactors of NBN and of the 26 and 70 kDa fragments arising from the 657del5 founder mutation. PLOS One 2014; 9(12):e114651
· 68. D’Alessandro A, Dzieciatkowska M, Peltz E, Moore EE, Jordan JR, Banerjee A, Hansen KC. Dynamic Changes in Rat Mesenteric Lymph Proteins Following Trauma Using Label-Free Mass Spectrometry. Shock 2014; 42(6):509-17
· 67. D’Alessandro A, Amelio I, Berkers CR, Antonov A, Melino G, Vousden K, Zolla L. Metabolic effect of TAp63α: enhanced glycolysis and pentose phosphate pathway, resulting in increased antioxidant defense. Oncotarget. 2014;5(17):7722-33
· 66. Dzieciatkowska M*, D’Alessandro A*, Wohlauer M, Moore EE, Banerjee A, Hansen KC. Lymph is not a Plasma Ultrafiltrate: A Proteomic Analysis of Injured Patients. Shock 2014; 42(6):485-98. * shared first authorship
· 65. Cialfi S, Palermo R, Manca S, De Blasio C, Vargas Romero P, Checquolo S, Bellavia D, Uccelletti D, Saliola M, D’Alessandro A, Zolla L, Gulino A, Screpanti I, Talora C. Loss of Notch1-dependent p21(Waf1/Cip1) expression influences the Notch1 outcome in tumorigenesis. Cell Cycle 2014; 13(13):2046-55.
· 64. Longo V, D’Alessandro A, Zolla L. Deoxygenation of leukofiltered erythrocyte concentrates preserves proteome stability during storage in the blood bank Blood Transfusion 2014; 12(4):599-604.
· 63. Prudent M, D’Alessandro A, Cazenave JP, Devine DV, Gachet C, Greinacher A, Lion N, Schubert P, Steil L, Thiele T, Tissot JD, Völker U, Zolla L. Proteome changes in platelets after pathogen inactivation--an interlaboratory consensus. Transfus Med Rev. 2014;28(2):72-83.
· 62. D’Alessandro A, Cervia D, Catalani E, Gevi F, Zolla L, Casini G. A metabolomic analysis of the protective effects of neuropeptides in retinal ischemia. Molecular Biosystems 2014; 10(6):1290-304.
· 61. Olivieri O, Cecconi D, Castagna A, Chiecchi L, Guarini P, Gunasekaran M, Morandini F, Brazzarola P, Zolla L, D’Alessandro A, Veglio F, Mulatero P, Pizzolo F. Urinary protease inhibitor Serpin B3 is higher in women and is further increased in female patients affected by aldosterone producing adenoma. Mol Biosystems 2014; 10(6):1281-9.
· 60. Pallotta V, Gevi F, D’Alessandro A, Zolla L.Red blood cell storage with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview. Blood Transfusion 2014;12(3):376-87.
· 59. Pallotta V, Naro F, Gevi F, D’Alessandro A, Zolla L. Supplementation of anti-oxidants in leukofiltered erythrocyte concentrates: assessment of morphological changes through scanning electron microscopy. Blood Transfusion 2014;12(3):421-4.
2014
· 58. D’Alessandro A*, Taamalli M*, Gevi F, Timperio AM, Ghnaya T*, Zolla L. Cadmium stress responses in Brassica juncea: hints from proteomics and metabolomics Journal of Proteome Research 2013; 12(11):4979-97. *shared first authorship
· 57. D’Alessandro A, Zolla L. Proteomics, Metabolomics and Cancer Drug Development. Exp Rev Prot 2013; 10(5):473-88.
· 56. D’Alessandro A, Marrocco C, Rinalducci S, Peschiaroli A, Timperio AM, Bongiorno-Borbone L, Finazzi Agrò A, Melino G, Zolla L. Analysis of TAp73-dependent signaling via omics technologies. Journal of Proteome Research 2013; 12(9):4207-20.
· 55. Pallotta V, D’Alessandro A, Rinalducci S, Zolla L. Native protein complexes in the cytoplasm of Red Blood Cells. J Proteome Res 2013;12(7):3529-46.
· 54. D’Alessandro A, Zolla L. Foodomics to investigate meat tenderness. Trends in Analytical Chemistry 2013; 52:47-53
· 53. Dando I, Donadelli M, Costanzo C, Dalla Pozza E, D’Alessandro A, Zolla L, Palmieri M. Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells. Cell Death and Diseases 2013; 4:e664. doi: 10.1038/cddis.2013.151
· 52. Timperio AM, Mirasole C, D’Alessandro A, Zolla L. Red Blood Cell Lipidomics analysis through HPLC-ESI-qTOF: application to red blood cell storage. J Integrated Omics 2013; DOI: 10.5584/jiomics.v2013i2013.123
· 51. Zolla L, D’Alessandro A, Parguina A, Garcia A. In reply to “Response to reply –response “Platelet Proteomics in Transfusion Medicine: a reality with a challenging but promising future” Blood Transfusion 2013; 11: 316
· 50. D’Alessandro A, Gevi F, Zolla L. Red blood cell metabolism under prolonged anaerobic storage. Molecular Biosystems 2013; 9(6):1196-209.
· 49. Zolla L, D’Alessandro A. An efficient apparatus for rapid deoxygenation of erythrocyte concentrates for alternative banking strategies. J Blood Transfusion 2013; 2013:896537.
· 48. D’Alessandro A, Mirasole C, Zolla L. Hemoglobin alpha glycation (Hb1Ac) increases during red blood cell storage: a MALDI-TOF mass spectrometry-based investigation. Vox Sanguinis 2013; 105(2):177-80.
· 47. Marrocco C, D’Alessandro A, Rinalducci S, Rebulla P, Zolla L. The IPTAS study: the effects of pathogen inactivation technology Mirasol on apheresis platelet concentrates. Transfusion 2013; 53(8):1808-20.
· 46. Peschiaroli A, Giacobbe A, Formosa A, Markert EK, Bongiorno-Borbone L, Levine AJ, Candi E, D’Alessandro A, Zolla L, Finazzi Agrò A, Melino G. MIR-143 regulates hexokinase 2 expression in cancer cells. Oncogene 2013; 32: 797-802.
· 45. D’Alessandro A, Zolla L. Meat science: from Proteomics to Integrated Omics towards System biology. J Proteomics 2013; 78:558-577.
· 44. D’Alessandro A, Blasi B, D’Amici GM, Marrocco C, Zolla L. Red blood cell populations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue. Blood Transfusion; 2013;11: 75-87.
· 43. Murgiano L, D’Alessandro A, Zolla L, Valentini A, Pariset L. Comparison of Milk Fat Globule Membrane (MFGM) Proteins in Milk Samples of Chianina and Holstein Cattle Breeds across three Lactation Phases through 2D IEF SDS PAGE – a preliminary study. Food Research International 2013; 54(1):1280-1286.
· 42. Zolla L, D’Alessandro A. Response to "Platelets proteomics in Transfusion Medicine: a reality with challenging but promising future". Blood Transfusion 2013;11(2):316.
2013
· 41. Zolla L, D’Alessandro A. Preface to the Special Issue Integrated Omics. J Proteomics 2012; 76:3-9.
· 40. Polati R, Castagna A, Bossi AM, Alberio T, De Domenico I, Kaplan J, Timperio AM, Zolla L, Federica G, D’Alessandro A, Brunch R, Olivieri O, Girelli D. Murine macrophages response to iron. J Proteomics 2012; 76:10-27.
· 39. Zolla L, D’Alessandro. Shaking hands with the future through Omics application in Transfusion Medicine and Clinical Biochemistry. Preface.Blood Transfusion 2012; 10(2):s1-3.
· 38. D’Alessandro A, Gevi F, Timperio AM, Giardina B, Zolla L. Clinical Metabolomics: the next stage of clinical biochemistry. Blood Transfusion 2012; 10(2):s19-24.
· 37. D’Amici GM, Mirasole C, D’Alessandro A, Yoshida T, Dumont LJ, Zolla L. Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome. Blood Transfusion 2012; 10(2):s46-54.
· 36. Marrocco C, Pallotta V, D’Alessandro A, Gilda A, Zolla L. Red blood cell populations and membrane levels of peroxiredoxin 2 as candidate biomarkers to reveal blood doping. Blood Transfusion 2012; 10(2):s71-7.
· 35. D’Alessandro A, Marrocco C, Rinalducci S, Mirasole C, Failla S, Zolla L. Chianina beef tenderness investigated through integrated Omics. J Proteomics 2012; 75(14):4381-98.
· 34. D’Alessandro A, Zolla L. Food safety and quality control: hints from proteomics. Food Technol Biotechnol 2012; 50(3):275-85.
· 33. Gevi F*, D’Alessandro A*, Rinalducci S, Zolla L. Alterations of Red Blood Cell metabolome during cold liquid storage of erythrocyte concentrates in CPD-SAGM. J Proteomics. 2012; 76:168-180. *shared first authorship
· 32. D’Alessandro A, Rinalducci S, Marrocco C, , Zolla V, Napolitano F, Zolla L. Love me tender: an omics window on the Maremmana meat tenderness network. J Proteomics 2012; 75(14):4360-80.
· 31. Blasi B, D’Alessandro A, Nicola Ramundo, Zolla L. Red blood cell storage and cell morphology.Transfusion Medicine 2012; 22(2):90-6.
· 30. Blasi B, D’Amici GM, D’Alessandro A, Zolla L. Native analysis of Plasma-derived clotting factor VIII concentrates: “sponge effect” and contaminants. Electrophoresis 2012; 33:1-7.
· 29. Pallotta V, D’Amici GM, D’Alessandro A, Rossetti R, Zolla L. Monitoring of red blood cells during processing for cryopreservation: from fresh blood to thaw-washing. Blood Cells, Molecules and Diseases 2012; 48(4):226-32.
· 28. D’Alessandro A, Zolla L. We are what we eat: food safety and proteomics. J Proteome Res 2012; 11(1):26-36.
· 27. D’Alessandro A, Gevi F, Palini S, Bulletti C, Zolla L. A mass spectrometry-based targeted metabolomics strategy of human blastocoele fluid: a promising tool in fertility research. Mol Biosyst. 2012 Apr;8(4):953-8.
· 26. D’Alessandro A, D’Amici GM, Vaglio S, Zolla L. Time-course Investigation of SAGM-Stored Erythrocyte Concentrates: from Metabolism to Proteomics. Hematologica 2012 ;97(1):107-15.
· 25. D’Alessandro A, Zolla L. Metabolomics and cancer drug discovery: let the cells do the talking. Drug Discov Today 2012; 17(1-2):3-9.
· 24. Timperio AM, D’Alessandro A, Fagioni M, Zolla L. Production of the phytoalexin trans-resveratrol and delta-viniferin in two economy-relevant grape cultivars upon infection with Botrytis cinerea in field conditions. Plant Physiology Biochemistry 2012; ;50(1):65-71.
· 23. D’Alessandro A, Gevi F, Zolla L. Targeted mass spectrometry-based metabolomic profiling through Multiple Reaction Monitoring of Liver and other biological matrices. Methods Mol Biol. 2012; In Liver Proteomics. In Methods and Protocols Series: Methods in Molecular Biology. 2012; vol. 909. Josic, Djuro; Hixson, Douglas C. (Eds.)
2012
· 22. D’Alessandro A, Marrocco C, Zolla V, D’Andrea MS, Zolla L. Meat quality and the Longissimus lumborum muscle of Casertana and Large White pigs: metabolomics and proteomics intertwined. J Proteomics 2011;75(2):610-27.
· 21. D’Amici GM, Blasi B, D’Alessandro A, Vaglio S, Zolla L. Plasma-derived clotting factor VIII: heterogeneity evaluation in the quest for potential inhibitory-antibody stimulating factors. Electrophoresis 2011; 32: 1-10.
· 20. D’Alessandro A, D’Amici GM, Timperio AM, Merendino N, Zolla L. Docosohaexanoic acid-treated PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomics, metabolomics and interactomics overview. J Proteomics. 2011;74(10):2138-58.
·19. Basco D, Nicchia GP, D’Alessandro A, Zolla L, Svelto M, Frigeri A. Absence of AQP4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling. PLOS ONE 2011; 6(4):e19225.
·18. D’Alessandro A, Zolla L. The SODyssey – Superoxide dismutases: from biochemistry, through proteomics, to oxidative stress, ageing and nutraceuticals. Exp Rev Proteomics. 2011; 8(3):405-21.
· 17. D’Alessandro A, Gevi F, Zolla L. A robust high resolution reversed-phase HPLC strategy to investigate various metabolic species in different biological models. Mol Biosyst. 2011; 7(4):1024-32.
· 16. D’Alessandro A, Rinalducci S, Zolla L. Redox proteomics and drug development. J Proteomics. 2011; 74(12):2575-95
· 15. D’Alessandro A, Zolla L, Scaloni A. The bovine milk proteome: cherishing, nourishing and fostering molecular complexity. An interactomics and functional overview. Mol Biosyst. 2011;7(3):579-97
2011
· 14. D’Alessandro A, Zolla L. Pharmacoproteomics: a chess game on a protein field. Drug Discov Today. 2010;15(23-24):1015-23.
· 13. Murgiano L, D’Alessandro A, Egidi MG, Crisà A, Prosperini G, Timperio AM, Valentini A, Zolla L. Proteomics and transcriptomics investigation on longissimus muscles in Large White and Casertana pig breeds. J Proteome Res. 2010;9(12):6450-66
· 12. D’Alessandro A, Grazzini G, Giardina B, Zolla L. In silico analyses of proteomic data suggest a role for heat shock proteins in umbilical cord blood hematopoietic stem cells. Stem Cell Rev. 2010;6(4):532-47.11. Egidi MG, D’Alessandro A, Mandarello G, Zolla L. Troubleshooting in platelet storage temperature and new perspectives through proteomics. Blood Transfus. 2010;8 Suppl 3:s73-81
· 10. D’Alessandro A, Zolla L. Proteomics for quality-control processes in transfusion medicine. Anal Bioanal Chem. 2010;398(1):111-24
· 9. D’Alessandro A, Scaloni A, Zolla L. Human milk proteins: an interactomics and updated functional overview. J Proteome Res. 2010;9(7):3339-73.
· 8. D’Alessandro A, Liumbruno G, Grazzini G, Zolla L. Red blood cell storage: the story so far. Blood Transfus. 2010;8(2):82-8.
· 7. Liumbruno G, D’Alessandro A, Grazzini G, Zolla L. How has proteomics informed transfusion biology so far? Crit Rev Oncol Hematol. 2010;76(3):153-72.
· 6. Liumbruno GM, D’Alessandro A, Rea F, Piccinini V, Catalano L, Calizzani G, Pupella S, Grazzini G. The role of antenatal immunoprophylaxis in the prevention of maternal-foetal anti-Rh(D) alloimmunisation. Blood Transfus. 2010;8(1):8-16.
· 5. D’Alessandro A, Righetti PG, Fasoli E, Zolla L. The egg white and yolk interactomes as gleaned from extensive proteomic data. J Proteomics. 2010;73(5):1028-42.
· 4. D’Alessandro A, Righetti PG, Zolla L. The red blood cell proteome and interactome: an update. J Proteome Res. 2010;9(1):144-63.
· 3. Timperio AM, D’Alessandro A, Pariset L, D'Amici GM, Valentini A, Zolla L. Comparative proteomics and transcriptomics analyses of livers from two different Bos taurus breeds: "Chianina and Holstein Friesian". J Proteomics. 2009;73(2):309-22.
· 2. Liumbruno G, D’Alessandro A, Grazzini G, Zolla L. Blood-related proteomics. J Proteomics. 2010;73(3):483-507.
· 1. D’Alessandro A, Liumbruno G, Grazzini G, Pupella S, Lombardini L, Zolla L. Umbilical cord blood stem cells: towards a proteomic approach. J Proteomics. 2010;73(3):468-82.
2010
· 1. D’Alessandro A. Preface. Meth Mol Biol; 2019 – High-throughput Metabolomics – D’Alessandro Editor. Springer Nature. ISSN: 978-1-4939-9235-5
· 2. Reisz JA, Zheng C, D’Alessandro A, Nemkov T. Untargeted and semi-targeted lipid analysis of biological samples using mass spectrometry-based metabolomics. Meth Mol Biol; 2019 – High-throughput Metabolomics – D’Alessandro Editor. Springer Nature. ISSN: 978-1-4939-9235-5
· 3. Nemkov T, Reisz JA, Gehrke S, Hansen KC, D’Alessandro A. High-throughput metabolomics: isocratic and gradient mass spectrometry-based methods. Meth Mol Biol; 2019 – High-throughput Metabolomics – D’Alessandro Editor. Springer Nature. ISSN: 978-1-4939-9235-5
· 4. Plecita-Hlavata L, D’Alessandro A, El Kasmi K, Li M, Zhang H, Jezek P, Stenmark KR. Metabolic reprogramming and redox signaling in pulmonary hypertension. in Pulmonary Vascular redox Signaling in Health and Disease. Edited by Yong-Xiao Wang. Advances in Experimental Medicine and Biology. Springer 2017
· 5. D’Alessandro A*, Zolla L. Biochemistry of red cell aging in vivo and storage lesions. Hematology Education: the education programme for the annual congress of the European Hematology Association 2013; 7(1):389-396 *corresponding author
· 6. Zolla L, D’Alessandro A. Proteomic Investigations on Stored Red Blood Cells. In Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood. Mozzarelli A. Editor; John Wiley and Sons Ltd The Atrium, Southern Gate Chichester, West Sussex, PO19 8SQ
Book chapters
· 7. Zolla L, D’Alessandro A. Chromatography of Membrane Proteins and Lipoproteins. Encyclopedia of Analytical Chemistry. 2011. R.A. Meyers (Ed.) Copyright John Wiley & Sons Ltd. DOI: 10.1002/9780470027318.a1607.pub2
· 8. D’Alessandro A, Scaloni A, Zolla L. Human milk proteins: strides in proteomics and benefits in nutrition research. In “Dietary and Nutritional Aspects of Human Breast Milk” – Book Chapter – cured by Dr Sherma Zibadi, Prof Ronald R Watson and Prof Victor R Preedy; Human health handbooks - 2212-375X, Volume 5. Wageningen Academic Publisher 2014; ISBN: 978-90-8686-209-2
· 9. Zolla L, D’Alessandro A, Lana A. Chromatography of Membrane Proteins and Lipoproteins. Peptides and Proteins Encyclopedia of Analytical Chemistry. Update; 2016. R.A. Meyers (Ed.) Copyright John Wiley & Sons Ltd. Waiting for doi